Density and Optical Properties of {Ciprofloxacin Hydrochloride + Aqueous-Ethanol} Mixtures at 30°C

Abstract

The paper deals with the calculation of molar refraction ( ) and polarizability ( ) of antibiotic drug ciprofloxacin hydrochloride ( = 0.001-0.029 mol⋅dm −3 ) solutions in ethanol-water mixtures of different compositions (30, 50, and 70% v/v) from measured density ( ) and refractive index ( ) at 30 ∘ C. The effect of drug concentration and composition of ethanol-water mixtures on density and optical properties of drug solutions has been described.

Design Considerations of an ITO-Coated U-Shaped Fiber Optic LMR Biosensor for the Detection of Antibiotic Ciprofloxacin

“…The next layer (Layer 2) is composed of ITO, and its dispersion relation according to the Drude formula can be written as [ 58 ]: where and and represent the collision and plasma wavelengths, respectively, and their corresponding values are 11.21076 m and 5.6497 m. Finally, the third layer (Layer 3) consists of a sensing medium in the form of CIP hydrochloride solutions having different concentrations (0.001 to 0.029 mol∙dm −3 ) and different compositions (30%, 50%, and 70% in volume ratio v / v ) in ethanol–water (E–W) mixtures at 30 °C. In that study, the authors used a thermostatically controlled Abbe Refractometer to measure the RI values of various concentrations of CIP hydrochloride as provided in Table 1 [ 59 ]. Furthermore, the concentration dependence of the refractive index (n) was studied using the following equation [ 60 ]: where K is a constant measured in the units of dm 3 ·mol −1 and depends on the chemical/physical properties of solute, c denotes the molar concentration of the antibiotic solution, and n 0 is the RI at infinite dilution whose corresponding values for 30%, 50%, and 70% compositions are 1.3448, 1.3525, and 1.3552, respectively.…”

“… Variation in the RI with the concentration of CIP hydrochloride solutions for different E–W mixtures [ 59 ]. …”