Dental Abnormalities after Treatment for Childhood Cancer

Mladosievičová, Beáta; Jurkovič, R; Hollá, Lýdie Izakovičová

doi:10.14735/amko201520

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…При проведении ЛТ поражение зубов развивается вследствие локального воздействия ионизирующего излучения на область голова-шея при солидных опухолях и гемобластозах, тотального облучения тела перед трансплантацией костного мозга (ТКМ) [17][18][19][20]. Поражение твердых тканей зубов связывают как с непосредственным действием на них облучения, так и с последующим иммунодефицитным состоянием, нарушением минерального и белкового обмена, количества и состава слюны, функциональ-ного состояния важнейших физиологических систем организма [21][22][23][24].…”

Section: Fig 1 Scheme Of Multidisciplinary Observation Of Patients unclassified

Radiation caries in patients receiving cancer therapy: a review of the literature and their own clinical observations

Обухов¹,

Жуковская²,

Karelin³

2019

Ross. ž. det. gematol. onkol.

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Introduction.This study focuses on topical issues of etiopathogenesis, clinic and treatment of radiation injuries of hard dental tissues in patients who completed antitumor therapy.Review of literature data.In the course of reviewing both domestic and foreign sources of literature covering certain aspects of the problem, the authors formulate the principles of the differential diagnosis of radiation caries, prevention and treatment specificity.Results.The studies were performed at the TRSC “Russkoe Pole” from January 2017 to August 2018 (the median is 20 months). A group of 2005 patients who received radiation therapy for the treatment of hemoblastosis, solid tumors, including for the purpose of consolidation before the hematopoietic stem cell transplantation, was selected. The most severe lesions of the dentition were detected in 74 (3.2 %) patients during the rehabilitation period, mainly with tumors of the central nervous system: radiation caries, trisism, adentia. Radiation caries is a common complication of radiation therapy in the treatment of malignant neoplasms in children and adolescents.Conclusion.The severity of radial caries is determined by the local dose and age of the patients at the time of exposure.Conflict of interest. The authors declare no conflict of interest.Funding. The study was performed without external funding.

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Section: Fig 1 Scheme Of Multidisciplinary Observation Of Patients unclassified

Radiation caries in patients receiving cancer therapy: a review of the literature and their own clinical observations

Обухов¹,

Жуковская²,

Karelin³

2019

Ross. ž. det. gematol. onkol.

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“…Other side effects of radiation includes Irradiation to the central nervous system may reduce hypothalamic pituitary function will be reduced, subsequently production of growth hormone and thyroid stimulation hormone will be diminished. This may, in turn, adversely affect the development of craniofacial complex [47][48][49].…”

Section: Oral Mucositismentioning

confidence: 99%

Dental Care of Children with Leukemia- An Overview

Degala¹,

Nirmala²

2016

JPNC

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“…Риск стоматологической патологии, индуцированной противоопухолевым лечением в период долгосрочной выживаемости, также имеет место [5]. Повреждение тканей с низким потенциалом восстановительных функций, таких как зубы, обусловливает высокую вероятность необратимых изменений [6]. Аномалии развития зубов включают нарушение количества, размеров, формы, минерализации зубов, дефекты формирования дентина и эмали [7].…”

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Dental disorders in patients recovered from malignant neoplasms in childhood

Smirnov

Сидоренко²

2021

Ross. ž. det. gematol. onkol.

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During the development of the bodyʼs homeostatic systems, anticancer drugs and radiation affect both tumor cells and healthy tissues. Damage to tissues with low potential for restorative functions, such as teeth, leads to a high probability of irreversible changes. The purpose of this literature review is to provide information on dental defects resulting from anticancer treatment. The most common anomalies in the development of teeth include a violation of the number, size, shape, mineralization of teeth, defects of dentin and enamel. The effect of a number of chemotherapeutic drugs has been studied in animal models and include a deficiency and thinning of the roots of the teeth. Irradiation leads to a wider spectrum of dental pathology: the integritation of the teeth changes, craniofacial dysmorphism, post-radiation mandibular hypomobility, damage to the salivary glands, the risk of developing osteoradionecrosis. The extent and severity of these effects depends from the child's age type of tumor and the radiation dose. The stage of tooth development is critical. Patients who received hematopoietic stem cell transplantation (HSCT) before the age of 3 have a higher risk of dental disorders and anomalies in the development and growth of the face. Radiation therapy plays a leading role in the formation of caries. The study of the long-term effects of radiation therapy, chemotherapy, HSCT on the development of dental complications is of interest to identify the most vulnerable groups of patients in order to ensure the possibility of early intervention and improve the quality of life.

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Dental Abnormalities after Treatment for Childhood Cancer

Cited by 5 publications

References 23 publications

Radiation caries in patients receiving cancer therapy: a review of the literature and their own clinical observations

Radiation caries in patients receiving cancer therapy: a review of the literature and their own clinical observations

Dental Care of Children with Leukemia- An Overview

Dental disorders in patients recovered from malignant neoplasms in childhood

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