Dental Anomalies in a Brazilian Cleft Population

Sá, Jamile de Oliveira; Mariano, Lorena Castro; Canguçú, Daiane Leite; Coutinho, Thaynara S L; Hoshi, Ryuichi; Medrado, Alena Peixoto; Martelli‐Júnior, Hercílio; Coletta, Ricardo D.; Reis, Sílvia Regina de Almeida

doi:10.1597/14-303

Cited by 20 publications

(22 citation statements)

References 38 publications

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“…In a study of 240 patients with BCLP 3.8% of patients exhibited oligodontia with upper laterals and upper and lower second premolars most frequently missing. Also of note is a significant incidence of supernumerary teeth in the patients with isolated cleft lip and also in some cases of BCLP [Riis et al, ; Sá et al, ].…”

Section: Discussionmentioning

confidence: 99%

Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features

Awadh

Kiukkonen

Nieminen

et al. 2017

American J of Med Genetics Pt A

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Blepharocheilodontic (BCD) syndrome is a rare condition characterized by bilateral cleft lip and palate (BCLP), eyelid abnormalities, and oligodontia. Despite orofacial clefting and oligodontia being central features of the condition, detailed reports of dental and craniofacial characteristics are scarce. The aim of this study was to analyze the dental and craniofacial features in a group of patients with BCD syndrome (three of which were related). Cephalometric radiographic analyses were performed on BCD syndrome patients (all radiographs taken at age 8 years) and compared to 40 randomly selected age-matched controls (20 non-syndromic BCLP, 20 non-cleft). Also, we assessed clinical records, photographs, dental study casts, and dental radiographs to determine the extent and pattern of tooth agenesis, dental morphology and malocclusion. BCD syndrome patients showed a very severe skeletal III malocclusion (maxillary-mandibular sagittal discrepancy) and reduced anterior lower face measurement compared to non-syndromic BCLP and non-cleft controls (P = 0.001, P = 0.027). All patients exhibited oligodontia (mean number of missing permanent teeth 13.7, range 7-17). All patients exhibited missing upper central and lateral incisor, upper canine and premolar teeth. Variations in dental morphology included taurodontism, conical-shaped teeth, and notching of the incisal edges. All patients had a short and narrow maxilla which translated into anterior and posterior cross bites. We conclude that, in our BCD syndrome group, the craniofacial skeletal defects are more severe than patients with BCLP. The pattern of tooth agenesis is unusual as it included teeth that are normally highly resistant to agenesis, namely upper central incisor and canine teeth. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features

Awadh

Kiukkonen

Nieminen

et al. 2017

American J of Med Genetics Pt A

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“…However, the findings suggested that the affected families did not have a higher genetic risk for dental anomalies than the general population and that the higher prevalence of these anomalies was mainly a consequence of various surgical interventions ( 14 ). However, this higher prevalence ( 3 , 11 , 15 , 16 ) of dental anomalies observed in cleft patients has been reported to be related to the existence of a common genetic link between oral clefts and dental anomalies in other studies ( 17 ). For instance, genes whose mutations are associated with tooth agenesis, such as MSX1 and PAX9, also contain single nucleotide polymorphisms as genetic risk factors for orofacial clefts ( 18 ).…”

Section: Discussionmentioning

confidence: 85%

“…A multifactorial model of genetic inheritance has been suggested for nonsyndromic cleft lip and/or palate (NSCL/P) based on the interaction of genetic and environmental factors ( 1 , 2 ). It is very common to observe different kinds of tooth anomalies in children with cleft lip and/or palate (CL/P), such as supernumerary teeth or missing teeth, microdontia, rotated teeth, hypoplasia, transpositions, and root deviation, usually detected on the cleft side ( 3 - 5 ). Tooth anomalies can be a challenge to the multidisciplinary health team treating these patients, but early detection improves treatment outcomes and orthodontic and surgical planning can be properly executed to obtain adequate aesthetic and functional results ( 3 - 9 ).…”

Section: Introductionmentioning

confidence: 99%

“…The development of CL/P and tooth germs involves a very close embryologic relationship in terms of timing and anatomical position ( 3 , 6 , 10 , 11 ). Johnson et al ( 12 ) have suggested that gene alterations associated with oral clefts can also produce many disturbances in other tissues, including changes in the dental lamina signaling pathway during odontogenesis, leading to dental malformations.…”

Section: Introductionmentioning

confidence: 99%

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Nonsyndromic cleft lip and/or palate: A multicenter study of the dental anomalies involved

et al. 2018

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BackgroundNonsyndromic cleft lip and/or palate (NSCL/P) is the most common craniofacial malformation. Due to the anatomical defect present in the alveolar process, these patients tend to exhibit more dental anomalies. The aim of this study was to identify the prevalence of dental anomalies in patients with NSCL/P by obtaining orthodontic documentation from Brazilian Centers for cleft lip and palate treatment.Material and MethodsA retrospective analysis (2000-2014) was conducted on orthodontic archives, radiographs and medical records of NSCL/P of 524 patients under orthodontic treatment. Panoramic radiographs and intra-oral photographs were examined to identify these anomalies. Categorical variables were expressed in terms of frequencies and percentages and analyzed using the Chi-Square test. The level of significance was set at p≤0.05 in all analyses.ResultsApproximately 83.3% of the individuals had at least one dental anomaly. Tooth agenesis was the most common abnormality found in those patients (87.8%) (p<0.001). Also, the largest number of dental anomalies was detected in the group of unilateral left clefts. The prevalence of dental anomalies in the present sample of NSCL/P patients was high and reached the highest levels in patients with alveolar bone clefts.ConclusionsThis study describes the most common dental anomalies observed in patients with NSCL/P. These abnormalities can cause significant problems that may be solved or minimized by early diagnosis and treatment. Key words:Cleft lip and/or palate, dental care for children, epidemiology, craniofacial abnormalities.

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“…NSOC and DA etiologies are attributed to complex interactions between genetic, epigenetic and environmental factors during the process of development 2,4-6 . The association between these congenital anomalies has been initially proposed because individuals with NSOC have a higher prevalence of DA than the general population 7,8 , and later studies demonstrated that genes and pathways related to tooth development are also involved with NSOC, reinforcing the putative link between DA and oral clefting 9,10 . Dental agenesis, supernumerary teeth, microdontia, fused teeth, ectopic eruption, gyroversion, taurodontism and enamel hypoplasia are considerably the more prevalent DA in individuals with NSOC 1,8,[11][12][13][14][15][16][17][18][19] . In addition, the severity these DA seems to be directly related to the severity of the NSOC [11][12][13]20,21 .…”

Section: Introductionmentioning

confidence: 99%

Patterns of dental anomalies in patients with nonsyndromic oral cleft

Machado

Coletta

et al. 2020

Braz. J. Oral Sci.

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Aim: To characterize the patterns of dental anomalies (DA) in the mixed and permanent dentitions of patients with nonsyndromic oral cleft (NSOC). Methods: This cross-sectional, observational, case-control study included 173 patients, 61 with mixed dentition (NSOC=29 and control=32) and 112 with permanent dentition (NSOC=57 and control=55). All subjected were submitted to clinical and radiographic examination. Dental anomalies of eruption, number, size and shape outside the cleft area were considered. Results: Although there was no statistical significance among patients with mixed dentition, dental agenesis was the anomaly more common in this group. In patients with permanent dentition, a higher prevalence of DA in NSOC group compared to control group was observed (p=0.02). Gyroversion and dental agenesis were the DA more frequently observed in the permanent dentition and the second premolar was the tooth more affected (p=0.003). Mandible and the left side were more involved, and dental agenesis was more frequently found in patients with unilateral cleft lip with or without cleft palate (NSCL±P). Conclusion: Our findings show a higher frequency of DA in NSOCs than in the control group in patients with permanent dentition, mainly due to a higher occurrence of agenesis of second premolars in patients with unilateral NSCL±P.

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Dental Anomalies in a Brazilian Cleft Population

Cited by 20 publications

References 38 publications

Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features

Blepharocheilodontic (BCD) syndrome: New insights on craniofacial and dental features

Nonsyndromic cleft lip and/or palate: A multicenter study of the dental anomalies involved

Patterns of dental anomalies in patients with nonsyndromic oral cleft

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