Dental Anomalies in Consanguineous Marriage: A Clinical-Radiological Study

Consanguineous Marriages and Dental Anomalies: A Cross-Sectional Analytical Study

“…The study proposed a significant correlation between consanguineous marriage and developmental dental anomalies in a particular size (microdontia) and morphological (dilaceration and taurodontism). Hence, results were coherent with our research analysis where taurodontism 30 (10.1%) and microdontia were seen in 12 (4%) participants [ 14 ].…”

Consanguineous marriage as a key indicator of isolated congenital dental anomaly among South Indian population – A cross-sectional study

“…Higher frequency of these anomalies was seen in consanguineous type (61.5%) in our study compared to the previous studies by Tayebi et al .,[ 7 ] Bağcı et al .,[ 8 ] Khan,[ 11 ] Lakshmayya et al .,[ 12 ] Shokry and Alenazy,[ 20 ] Alsoleihat and Khraisat,[ 21 ] Packyanathan and Preetha,[ 22 ] and Kanaan et al . [ 23 ] in their respective population-based studies.…”

“…It was proposed that the effect of consanguineous marriage on the development of higher variants of isolated dental anomalies had been attributed to increase in the presence of two identical alleles of a particular gene associated with subsequent failure of resistance to environmental factors associated. [ 8 ] However, the exact role of genetic or molecular dynamics in incidence of homozygous mutation, frequency of chromosomal aberrations, increased expression of identical allele associated with consanguineous marriage has not yet been fully established in the previous literature. Pedigree analysis studies with genetic expression analysis using methods like In situ -hybridization expression technique,[ 24 ] whole-exome sequencing[ 25 ] focusing on the influence of molecular pattern on dental evolution correlated with morphological variations can help in characterization of these isolated anomalies.…”

“…In accordance with this, we also observed first cousin marriages are more common than other types of consanguineous marriages. Bağcı et al .,[ 8 ] Khan[ 11 ] and Hamamy[ 13 ] put forward that this specific pattern of increased rates of marriages between first cousins among the south Indian population can be related to customs, civilization, religious belief, philosophy, cultural practices and geographical location. Conventionally, two different hypotheses namely competition over companions and property/assets have been shown to initiate both sex-biased investment and sex-biased dispersal patterns were put forward[ 32 ] however several other factors such as cultural norms, taboos, preferences of having powerful elder-generation partners, living close with their grandparents, Joint family norms like family bonds, secure and safety that enforces family harmony were believed to play a predominant role.…”

“…It was widely accepted that consanguineous marriages are an important factor in the transmission of congenital defects and autosomal recessive diseases from one generation to the next with an increased risk of detrimental effects on offspring or even results in postnatal mortality. [ 8 ]…”