Dental Applications of Nanodiamonds

Najeeb, Shariq; Khurshid, Zohaib; Agwan, Muhammad Atif Saleem; Zafar, Muhammad Sohail; Alrahabi, Mothanna; Qasim, Syed Saad Bin; Sefat, Farshid

doi:10.1166/sam.2016.2993

Cited by 30 publications

(11 citation statements)

References 64 publications

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“…Their potential is under investigation for use in different therapy platforms in various fields of medicine, such as drug delivery, tissue regeneration, and gene therapy. Recent research also suggests that NDs could also be used as bioactive or antibacterial dental implant coatings [86,87]. However, no study has been found that incorporates NDs into dental restorative materials and which meets the inclusion criteria of the present review [86,87].…”

Section: Discussionmentioning

confidence: 97%

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

et al. 2020

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Background and Objectives: Nanotechnology has become a significant area of research focused mainly on increasing the antibacterial and mechanical properties of dental materials. The aim of the present systematic review and meta-analysis was to examine and quantitatively analyze the current evidence for the addition of different nanoparticles into dental restorative materials, to determine whether their incorporation increases the antibacterial/antimicrobial properties of the materials. Materials and Methods: A literature search was performed in the Pubmed, Scopus, and Embase databases, up to December 2018, following PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines for systematic reviews and meta-analyses. Results: A total of 624 papers were identified in the initial search. After screening the texts and applying inclusion criteria, only 11 of these were selected for quantitative analysis. The incorporation of nanoparticles led to a significant increase (p-value < 0.01) in the antibacterial capacity of all the dental materials synthesized in comparison with control materials. Conclusions: The incorporation of nanoparticles into dental restorative materials was a favorable option; the antibacterial activity of nanoparticle-modified dental materials was significantly higher compared with the original unmodified materials, TiO2 nanoparticles providing the greatest benefits. However, the high heterogeneity among the articles reviewed points to the need for further research and the application of standardized research protocols.

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Section: Discussionmentioning

confidence: 97%

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

et al. 2020

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“…A number of studies have revealed mechanical similarities between nano-hybrid and micro-hybrid materials based on filler types, morphologies, and volume fractions 36 . On the other hand, researchers have also reported superior18, 37, 38 or inferior39, 40 properties of micro-hybrid materials compared to nano-filled composites. Such variations are mainly due to the use of different characterisation techniques and parameters 41 .…”

Section: Discussionmentioning

confidence: 99%

Effects of deformation rate variation on biaxial flexural properties of dental resin composites

Kumar

Zafar

Dahri

et al. 2018

Journal of Taibah University Medical Sciences

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Objectives This study aimed to determine the biaxial flexural strength (BFS) of resin composite materials at distinct deformation rates. Methods Two micro-hybrid [Filtek Z100™ Restorative (Z100), Filtek™ Z250 (Z250)] and two nano-filled [Filtek™ Supreme XT Body (FSB), Filtek™ Supreme Translucent (FST)] composite resins were selected. Disc-shaped (12 × 1 mm) specimens were fabricated using nylon split moulds. Bar-shaped specimens (25 × 2 × 2 mm) were fabricated from each material to determine the flexural modulus. The specimens were tested for BFS and flexural modulus under dry and wet conditions after 1, 13, and 52 weeks. Results The highest BFS was recorded for Z250 (162 ± 19 MPa), followed by FST (154 ± 16 MPa), Z100 (150 ± 18 MPa), and FSB (136 ± 18 MPa). The materials exhibited a clear trend of increase in BFS with deformation rate. Following immersion for 1 week, the BFS was 126 ± 18 MPa for Z100, and 124 ± 17 MPa for Z250, which were higher than those of FSB (99 ± 16 MPa) and FST (115 ± 19 MPa) under comparable conditions. There was a remarkable reduction in the flexural moduli of the specimens immersed for 1 week compared to those of the dry specimens: Z100 (from 18.3 ± 1.2 GPa for dry specimen to 15.7 ± 0.8 GPa after immersion for 1 week), Z250 (from 16.7 ± 0.8 GPa to 13.3 ± 1.4 GPa), FSB (from 13.7 ± 0.6 GPa to 11.0 ± 2.1 GPa) and FST (from 12.7 ± 2.3 GPa to 10.4 ± 1.0 GPa). Conclusion This study concludes that the BFS and flexural moduli of resin-based dental restoratives decline when they are immersed in an aqueous medium until saturation with water. However, after equilibrium is established, the immersion medium does not affect the restorative materials further. Variations in deformation rate did not have a significant effect on the BFS of resin-based dental restoratives.

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“…Nanocarbon family has superior physical and chemical properties and antibacterial effect 21 . Nanodiamonds (NDs) belong to the nanocarbon family and have advantages over other metal/metal-oxide nanoparticles for being more chemically stable, biocompatible, and not inducing cytotoxicity 22 . They are used in different fields of Medicine and Dentistry, including guided tissue regeneration, polymer reinforcement, and antibacterial dental implant coatings 22 , 23 …”

Section: Introductionmentioning

confidence: 99%

The effect of nanodiamonds on candida albicans adhesion and surface characteristics of PMMA denture base material - an in vitro study

et al. 2019

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Candida albicans is the main causative pathogen of denture stomatitis, which affects many complete denture patients. Objective: To evaluate the effect of different concentrations of nanodiamonds (NDs) added to polymethyl methacrylate (PMMA) denture base material on Candida albicans adhesion as well as on surface roughness and contact angle. Methodology: Acrylic resin specimens sized 10×10×3 mm3 were prepared and divided into four groups (n=30) according to ND concentration (0%, 0.5%, 1%, 1.5% by wt). Surface roughness was measured with a profilometer, and the contact angle with a goniometer. The effect of NDs on Candida albicans adhesion was evaluated using two methods: 1) slide count and 2) direct culture test. Analysis of variance (ANOVA) and Tukey's post hoc test were used in the statistical analyses. Results: Addition of NDs decreased the Candida albicans count significantly more than in the control group (p<0.05), with a lowest of 1% NDs. Addition of NDs also significantly decreased the surface roughness (p<0.05), but the contact angle remained the same. Incorporation of NDs into the PMMA denture base material effectively reduced Candida albicans adhesion and decreased surface roughness. Conclusion: PMMA/NDs composites could be valuable in the prevention of denture stomatitis, which is considered one of the most common clinical problems among removable denture wearers.

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Dental Applications of Nanodiamonds

Cited by 30 publications

References 64 publications

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

Antibacterial Properties of Nanoparticles in Dental Restorative Materials. A Systematic Review and Meta-Analysis

Effects of deformation rate variation on biaxial flexural properties of dental resin composites

The effect of nanodiamonds on candida albicans adhesion and surface characteristics of PMMA denture base material - an in vitro study

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