Dental caries and periodontal status in children with type 1 diabetes mellitus

Pachoński, Marek; Jarosz-Chobot, Przemysława; Koczor-Rozmus, Aleksandra; Łanowy, Patrycja; Mocny‐Pachońska, Katarzyna

doi:10.5114/pedm.2020.93249

Cited by 17 publications

(24 citation statements)

References 13 publications

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“…Regarding the influence of glycemic control elements on the presence of gingivitis, data are not conclusive, suggesting other factors, such as those related to patients' immunological responses (55). A recent study showed no significant differences in periodontal status between controlled and poorly controlled diabetic patients and healthy children (56). In a case-control study involving 80 children and adolescents (aged 5-18 years) with T1DM, a significant effect of diabetes on an increased risk of oral and periodontal diseases in children was not confirmed (57).…”

Section: Plaque-induced Gingivitis and T1dmmentioning

confidence: 99%

Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

et al. 2021

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Oral childhood diseases, such as caries and gingivitis, have much more than a local impact on the dentition and tooth surrounding tissues, which can affect systemic conditions. While the mouth is frequently exposed to microbial stressors that can contribute to an inflammatory state in the entire body, chronic disorders can also interfere with oral health. Sharing common risk factors, a dynamic interplay can be driven between 1. dental caries, gingivitis, and type I diabetes mellitus, 2. early childhood caries and obesity, and 3. caries and cardiovascular diseases. Considering that there are ~2.2 billion children worldwide and that childhood provides unique opportunities for intervention targeting future health promotion, this review is of prime importance and aimed to explore the relationship between the oral microbiome and oral chronic diseases driven by metabolic dysfunction in childhood.

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Section: Plaque-induced Gingivitis and T1dmmentioning

confidence: 99%

Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

et al. 2021

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“…Діти з цукровим діабетом, незалежно від вираженості патологічного процесу в пародонті, повинні перебувати на обліку у лікарястоматолога. Лікувально-профілактичні заходи стоматологом слід проводити з урахуванням основного соматичного захворювання [10,11].…”

Section: вступunclassified

“…Наявність у дітей цукрового діабету І типу є основним фактором ризику виникнення запальних захворювань пародонту. Для дітей з даною ендокринною патологією характерні наступні особливості: вимушений частий прийом їжі (часто з метою попередження гіпоглікемії діти вживають вуглеводи швидкої дії у вигляді меду чи льодяників); порушення процесів самоочищення в порожнині рота; зменшення резистентності макроорганізму і локальних факторів захисту; порушення в системі орального гомеостазу, обумовлені змінами в регуляторній (інтегративній), секреторній, захисній, видільній, мінералізуючій і травній функції слинних залоз; акумуляція зубного нальоту; мінімальний рівень протиінфекційного захисту ротової порожнини; підви-щення активності анаеробної мікробної флори; систематичне транзитне оновлення агресивної мікрофлорою еко ніші ротової порожнини через коливання рівня глікованого гемоглобіну; гіпосалівація і т.д [4,6,10].…”

Section: вступunclassified

Analysis of the Relationship of Behavioral Habits and Periodontal Status and Oral Health in Children of Primary School Age With Diabetes Mellitus Type I and Parents Results Using Dental Questionnaire

Kuz

2021

Act. Probl. of the Modern Med.

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Type I diabetes mellitus is an autoimmune disease in genetically susceptible individuals that leads to the destruction of pancreatic β-cells with the subsequent development of absolute insulin deficiency. The presence of type I diabetes mellitus in children is the main risk factor for the onset of inflammatory periodontal diseases. When comparing the values of the hygiene indices according to Fedorov - Volodkina and the simplified OHI-S index (Green-Vermillion), a statistically significant difference (p ≤ 0.05) was found when comparing groups 1 and 2, 3 and 4, 2 and 4, 1 and 4 and was not found (p≥0.05) between groups 1 and 3 (in children with healthy gums with and without type I diabetes). We also found a statistically significant difference between patients with type 1 diabetes and healthy children in periodontal indices and gingival indices. Inflammatory processes in the periodontium of children with diabetes are elevated, so it is very important to recognize and diagnose them as soon as possible. Based on the answers to the "Dental questionnaire for children and parents" (certificate of copyright registration, registration date 01.24.2020), the relationship between behavior patterns, parent’s habits and the dental status of schoolchildren was quite informative, it opens up the possibility of early detection of problems in medical and preventive work among the children. We made the following conclusions: by questioning parents, we can reveal their attitude to their dental health and dental health of children, as well as to determine in more detail the risk factors for periodontal disease and dental diseases in general. Despite the availability of educational programs and routine dental examinations in kindergartens and schools (they are mainly focused on the formation of a conscious attitude to dental health directly in children), the dental literacy of parents should be increased.

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“…The early detection of at-risk youngsters could reduce the incidence of caries lesions per patient and the average cost for prevention and treatment. The number of studies trying to correlate salivary proteins and dental caries has considerably increased [ 7 , 24 , 26 , 27 , 28 , 29 , 30 ]. It has been reported that changes in salivary protein compositions are involved in dental caries etiology [ 26 , 29 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

et al. 2021

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Saliva, an essential oral secretion involved in protecting the oral cavity’s hard and soft tissues, is readily available and straightforward to collect. Recent studies have analyzed the salivary proteome in children and adolescents with extensive carious lesions to identify diagnostic and prognostic biomarkers. The current study aimed to investigate saliva’s diagnostic ability through proteomics to detect the potential differential expression of proteins specific for the occurrence of carious lesions. For this study, we performed bioinformatics and functional analysis of proteomic datasets, previously examined by our group, from samples of adolescents with regulated and unregulated type 1 diabetes, as they compare with healthy controls. Among the differentially expressed proteins relevant to caries pathology, alpha-amylase 2B, beta-defensin 4A, BPI fold containing family B member 2, protein S100-A7, mucin 5B, statherin, salivary proline-rich protein 2, and interleukin 36 gamma were significantly downregulated in poorly-controlled patients compared to healthy subjects. In addition, significant biological pathways (defense response to the bacterium, beta-defensin activity, proline-rich protein activity, oxygen binding, calcium binding, and glycosylation) were deregulated in this comparison, highlighting specific molecular characteristics in the cariogenic process. This analysis contributes to a better understanding of the mechanisms involved in caries vulnerability in adolescents with unregulated diabetes.

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Dental caries and periodontal status in children with type 1 diabetes mellitus

Abstract: Dental caries and periodontal status in children with type 1 diabetes mellitus Intensywność próchnicy zębów oraz stan przyzębia u dzieci chorujących na cukrzycę typu 1

Cited by 17 publications

References 13 publications

Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

Exploring the Interplay Between Oral Diseases, Microbiome, and Chronic Diseases Driven by Metabolic Dysfunction in Childhood

Analysis of the Relationship of Behavioral Habits and Periodontal Status and Oral Health in Children of Primary School Age With Diabetes Mellitus Type I and Parents Results Using Dental Questionnaire

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

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