Dental Caries in the Syrian Hamster

Keyes, Paul H.; Shourie, K. L.

doi:10.1177/00220345490280020401

Cited by 15 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among all rat groups not infected by S. mutans, consumption of the sucrose-containing diet supported no more sulcal caries activity than did consumption of the glucose-containing diet; however, among these same groups, sucrose consumption supported slightly more smooth surface caries activity in one experiment than did glucose consumption. DISCUSSION Early studies in experimental animals showed a strong sucrose dependency (7,9,12,17,22,24,39) of caries in hamsters, an animal model whose teeth are essentially free of fissures, thus possessing only smooth surfaces (19). These studies employed Bratthall serotype a and b strains such as HS-1, HS-6, E-49, AHT, 3720, and BHT.…”

Section: Resultsmentioning

confidence: 99%

Essential dependence of smooth surface caries on, and augmentation of fissure caries by, sucrose and Streptococcus mutans infection

Tanzer¹

1979

Infect Immun

View full text Add to dashboard Cite

Streptococcus mutans-free Osborne-Mendel rats were used to study the ability of well-characterized S. mutans strains of Bratthall serotypes c, d, and E to form plaque and cause caries when the animals consumed either sucrose-or glucosecontaining diets. All of the serotype representatives successfully infected, colonized, and emerged in the oral ecology of animals, independent of the carbohydrate supplementation ofthe diet. However, the sucrose-containing diet supported higher percentages of S. mutans of all the serotypes in the plaque and greater amounts of plaque on the teeth. Smooth surface caries was essentially S. mutans dependent and sucrose dependent; fissure caries, although it was neither dependent on S. mutans infection nor sucrose consumption, was augmented by both. This sucrose-associated emergence of all three serotype representatives in the plaque flora and their virulence in the production of caries can be ascribed to their production of alkali-soluble a-(1-* 3)-rich glucans from sucrose.

show abstract

Section: Resultsmentioning

confidence: 99%

Essential dependence of smooth surface caries on, and augmentation of fissure caries by, sucrose and Streptococcus mutans infection

Tanzer¹

1979

Infect Immun

View full text Add to dashboard Cite

show abstract

“…Collectively, these organisms comprise a distinct subgroup of the viridans streptococci (15), which we refer to as the mutans streptococci. All mutans streptococci which have been tested in appropriate animal model systems can induce dental caries of varying degrees of severity (16,19,20,22,33,37,53), and they are considered to be a major factor in the etiology of human dental caries (4, 13,14,22,24,27,31,40).…”

mentioning

confidence: 99%

Prevalence, distribution of serotypes, and cariogenic potential in hamsters of mutans streptococci from elderly individuals

Fitzgerald¹,

Fitzgerald²,

Adams³

et al. 1983

Infect Immun

View full text Add to dashboard Cite

The prevalence of mutans streptococci (Streptococcus mutans, Streptococcus cricetus, Streptococcus sobrinus, and Streptococcus rattus) was determined in the salivas of 169 elderly individuals ranging in age from 60 to 87 years. Approximately 40% of these individuals were edentulous and wore full upper and lower dentures. With the exception of a higher proportion of saliva counts below 1,000 CFU/ml in the full-denture wearers, the prevalence and the serotype and species distributions of the mutans streptococci were similar in the denture wearers and individuals with natural teeth only. The species and serotype distributions of mutans streptococci in this elderly population were also consistent with reported observations of other workers on younger, more caries-prone populations. A total of 87 representative isolates of the mutans streptococci were tested for cariogenic potential in a hamster model system. A considerable degree of variation in virulence between different strains was observed. However, these differences were not relatable to individual species or serotypes or to whether the organisms were isolated from denture wearers or naturally dentate subjects. The results of our studies indicate that elderly individuals with either natural or artificial dentitions may be a hitherto unrecognized reservoir of mutans streptococci having varying degrees of potential cariogenicity. Hence, in close family situations they could serve, along with parents and siblings, as vectors in the initial transmission of cariogenic microorganisms to young children.

show abstract

Some anatomical characteristics of eight inbred strains ofMesocricetus auratus auratus (Syrian hamster)

Homburger¹,

Nixon²,

Baker³

et al. 1964

J Genet

View full text Add to dashboard Cite

Dental Caries in the Syrian Hamster

Cited by 15 publications

References 4 publications

Essential dependence of smooth surface caries on, and augmentation of fissure caries by, sucrose and Streptococcus mutans infection

Essential dependence of smooth surface caries on, and augmentation of fissure caries by, sucrose and Streptococcus mutans infection

Prevalence, distribution of serotypes, and cariogenic potential in hamsters of mutans streptococci from elderly individuals

Some anatomical characteristics of eight inbred strains ofMesocricetus auratus auratus (Syrian hamster)

Contact Info

Product

Resources

About