Dental caries is a preventable infectious disease

Balakrishnan, M.; Simmonds, Robin S.; Tagg, John

doi:10.1111/j.1834-7819.2000.tb00257.x

Cited by 167 publications

(131 citation statements)

References 83 publications

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“…The species most commonly implicated in caries development in man are Streptococcus mutans and S. sobrinus [2,4]. One feature of the mutans streptococci is their relatively high frequency of production of bacteriocins or bacteriocin-like inhibitory substances (BLIS).…”

Section: Introductionmentioning

confidence: 99%

“…The mutans streptococci are a group of seven oral streptococcal species that share a number of phenotypic, ecological and pathogenic attributes, among which is a high association with dental caries in man and some animal species [1][2][3][4]. The species most commonly implicated in caries development in man are Streptococcus mutans and S. sobrinus [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Different bacteriocin activities of Streptococcus mutans reflect distinct phylogenetic lineages

Balakrishnan

Simmonds

Kilian

et al. 2002

Journal of Medical Microbiology

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Bacteriocins produced by mutans streptococci are known as mutacins. In this study 16 broadly active mutacin-producing Streptococcus mutans strains from New Zealand, North America and Europe were classified into four groups (A-D) on the basis of differences in their activity in deferred antagonism tests against either the homologous producer strain (to test for presence of self-immunity) or indicator strains Staphylococcus aureus 46 and Enterococcus faecium TE1. Two of the strains included in the study (UA140 and UA96) were representatives of the group I and II mutacin producer strains previously described by Caufield and co-workers. One of the New Zealand isolates of group A (S. mutans strain N) appeared to produce inhibitory activity similar to that of the group I prototype strain UA140. Four other New Zealand isolates of group B (S. mutans strains M19, M34, B34 and D14) had mutacin II-like activity. The group B mutacin producers differed from the group A mutacin producers in their additional activity against Staph. aureus 46. Seven S. mutans strains (M46, B46, B57, M12, M28, B28 and 13M) were distinguished from the group A and group B mutacin producers in that they inhibited E. faecium TE1. These were called group C mutacin producers. Strains H7 and H23 resembled the group C strains in their action on both indicator strains TE1 and 46. However, these two strains failed to exhibit immunity to their own inhibitory products in the deferred antagonism test and were separately classified as group D mutacin producers. Phylogenetic analysis of the strains by several genotypic and phenotypic characteristics revealed that the mutacin groups were associated with distinct evolutionary lineages of S. mutans.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Different bacteriocin activities of Streptococcus mutans reflect distinct phylogenetic lineages

Balakrishnan

Simmonds

Kilian

et al. 2002

Journal of Medical Microbiology

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“…Production of bacteriocins (cationic peptides synthesized on ribosomes with antimicrobial activity that have a narrow spectrum of action) [27][28][29]. …”

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confidence: 99%

Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

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Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

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“…Uma vez que o S. mutans foi isolado e identificado como o principal agente etiológico para o desenvolvimento da cárie dental em humanos (JORDAN; KRASSE; MÖLLER, 1968;LEHNER et al, 1981;CLARK;HIRST;JEPSON, 1998), medidas preventivas incluindo a remoção da placa dental, uso do flúor em água potável e em produtos de higiene, tem sido empregadas para controle do patógeno (BALAKRISHNAN;SIMMONDS;TAGG, 2000;LEVINE;OWEN;AVERY, 2005).…”

Section: A Cárie Dental E O Streptococcus Mutansunclassified

“…Entretanto, ainda não existe nenhuma vacina licenciada disponível para humanos que atue na prevenção contra essa infecção (HUIMIN, 2013). Em diversos estudos, o principal alvo empregado nas estratégias tem sido o mecanismo primário de adesão utilizado pelo S. mutans (BALAKRISHNAN;SIMMONDS;TAGG, 2000;ZHANG, 2013).…”

Section: Antígenos Vacinais Contra a Cárie Dentalunclassified

Desenvolvimento de uma estratégia vacinal dose-reforço heterológo baseada em linhagens recombinantes de <i>Bacillus subitilis</i> para o controle de <i>Spreptococcus mutans</i>.

Silva¹

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Dental caries is a preventable infectious disease

Cited by 167 publications

References 83 publications

Different bacteriocin activities of Streptococcus mutans reflect distinct phylogenetic lineages

Different bacteriocin activities of Streptococcus mutans reflect distinct phylogenetic lineages

Probiotics and Periodontal Diseases

Desenvolvimento de uma estratégia vacinal dose-reforço heterológo baseada em linhagens recombinantes de <i>Bacillus subitilis</i> para o controle de <i>Spreptococcus mutans</i>.

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