Dental gold alloys and contact hypersensitivity

Vamnes, Jan Sverre; Morken, Tore; Helland, Ståle J.; Gjerdet, Nils Roar

doi:10.1034/j.1600-0536.2000.042003128.x

Cited by 51 publications

(36 citation statements)

References 21 publications

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“…Case reports support that there may be a bene®cial effect of replacing dental materials containing the relevant substance, as has been shown in two patients documented earlier (28). It is our opinion, however, that patients with positive patch tests to gold in general do not need to replace gold-containing dental restorations except in cases where the patients also exhibit local intraoral reactions or skin reactions to, e.g.…”

Section: Discussionsupporting

confidence: 62%

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Four years of clinical experience with an adverse reaction unit for dental biomaterials

Vamnes

Lygre

Grönningsæter

et al. 2004

Comm Dent Oral Epid

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Generally, we could not establish a straightforward cause-and-effect relationship between the presence of dental biomaterials and general symptoms. Twenty patients were advised to replace restorative materials because of contact lesions. Another 20 patients were recommended replacement of materials because of allergy verified with positive patch tests. The complex nature of most of the reactions requires a multidisciplinary approach to the care taking of patients who are concerned about reactions from dental materials, particularly amalgam.

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Section: Discussionsupporting

confidence: 62%

“…The most striking ®nding from the patch testing was the high frequency of positive reactions to gold. However, it should be considered that the present patients are selected in terms of complaints and presence of dental materials (28).…”

Section: Discussionmentioning

confidence: 99%

Four years of clinical experience with an adverse reaction unit for dental biomaterials

Vamnes

Lygre

Grönningsæter

et al. 2004

Comm Dent Oral Epid

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“…In dermatitis patients, contact allergy to gold and presence of dental gold are associated. The first indication of an over-representation of higher frequencies of contact allergy to gold in patients with gold restorations in a questionnaire study was published in 1994 (18) and the results were confirmed in clinical studies groups (19,20). The relationship between presence and amount of dental gold and contact allergy to gold has thereafter been verified in a cohort study with appropriate methodological testing (21).…”

mentioning

confidence: 86%

Contact Allergy to Gold in Patients with Oral Lichen Lesions

Ahlgren¹,

Bruze²,

Möller³

et al. 2012

Acta Derm Venerol

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The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two control groups tested were under examination for a tentative diagnosis of allergic dermatitis not related to oral problems. The frequency of contact allergy to gold was 28.9% in the patients with oral lichen lesions, 18.2% in patients selected from files, and 22.9% in the clinically examined control patients. The difference in frequency between patients with oral lichen lesions and those taken from files was statistically significant.

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“…Another factor may be the lower frequency of gold dental fillings in the Scottish than in the Swedish population[19]. A positive correlation between contact allergy to gold and the presence of dental gold has been suggested [20-22] and recently ascertained[23]. …”

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines

et al. 2002

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Objective: To study the clinical and biochemical effects of a low starting dose for gold therapy in rheumatoid arthritis patients with a contact allergy to gold.Methods: Serum cytokines were assayed before and 24 h after the first injection of gold sodium thiomalate (GSTM).Results: Contact allergy to gold was found in 4 of 19 patients. Compared to gold-negative patients (starting dose: 10 mg GSTM), there was a larger increase in serum TNFalpha (p < 0.05), sTNF-R1 (NS), and IL-1 ra (p < 0.05) in gold-allergic patients. Conclusions:Cytokines are released in blood by GSTM in RA patients with gold allergy. To minimize the risk of acute adverse reactions the starting dose of GSTM should be lowered to 5 mg. Alternatively, patients should be patch-tested before gold therapy; in test-positive cases, 5 mg is recommended as the first dose.

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Dental gold alloys and contact hypersensitivity

Cited by 51 publications

References 21 publications

Four years of clinical experience with an adverse reaction unit for dental biomaterials

Four years of clinical experience with an adverse reaction unit for dental biomaterials

Contact Allergy to Gold in Patients with Oral Lichen Lesions

Rheumatoid arthritis, gold therapy, contact allergy and blood cytokines

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