Dental implants in patients with head and neck cancer—A systematic review and meta‐analysis of the influence of radiotherapy on implant survival

Schiegnitz, Eik; Reinicke, Katrin; Sagheb, Keyvan; König, Jochem; Grötz, K. A.

doi:10.1111/clr.13976

Cited by 23 publications

(25 citation statements)

References 89 publications

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“… Schiegnitz y cols. 16 observan una supervivencia global media del implante del 87,8 %, siendo la tasa significativamente mayor de fracaso del implante en el hueso irradiado en comparación con el hueso no irradiado OR = 1,97 (IC 95 %; 1,63 a 2,37), además de ser estos más propensos a fallar en comparación a las zonas no irradiada OR = 2,26 (IC 95 %; 1,50 a 3,40).…”

Section: Resultados De Interés Principalunclassified

“…(ítem 1), mientras que solo tres estudios 5,15,16 especifican una declaración explícita sobre la realización y registro de un protocolo previo al estudio (ítem 2), así como también los seis estudios 2,4,5,14-16 presentan una justificación parcial sobre el porqué de los diseños incluidos (ítem 3).…”

Section: Evaluación Metodológicaunclassified

“…En cuanto a la elegibilidad, dos estudios 4,15 proporcionan en forma parcial una lista y justificación de todos los estudios potencialmente relevantes evaluados por texto completo que fueron excluidos de la revisión, mientras que los cuatro restantes 2,5,14,16 no proporcionan datos (ítem 7), siendo la descripción de todos los estudios analizados reportadas en forma exhaustiva (ítem 8), donde los seis estudios 2,4,5,14-16 aplicaron técnicas satisfactorias para evaluar el riesgo de sesgo de los estudios incluidos en sus revisiones (ítem 9). Sin embargo, ninguno de los autores 2,4,5,14-16 reportó las fuentes de financiación de los estudios incluidos en sus respectivas revisiones (ítem 10).…”

Section: Evaluación Metodológicaunclassified

“…Todos los estudios 2,4,5,14-16 plasman un metanálisis con métodos apropiados para la combinación estadística de resultados (ítem 11), siendo evaluados e interpretados el impacto potencial del riesgo de sesgo sobre los resultados del metanálisis, proporcionando una explicación satisfactoria sobre la heterogeneidad y magnitud del sesgo de publicación, además de informar cualquier potencial fuente de conflicto de interés (ítem 12, ítem 13, ítem 14, ítem 15, ítem 16). En forma general, los estudios poseen una calidad metodológica media 4,5,14,16 y alta 2,15 , por tanto, un bajo riesgo de sesgo tanto para subestimación o sobreestimación de los hallazgos.…”

Section: Evaluación Metodológicaunclassified

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Radioterapia y riesgo de supervivencia en implantes dentales: Resumen de revisiones sistemáticas.

Fuentes-Barría¹,

Eguía²

2023

j.maxilo

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La radioterapia es el principal factor de riesgo para la rehabilitación oral con implantes. El objetivo de este trabajo fue evaluar, mediante un resumen de revisiones sistemáticas, la supervivencia de los implantes colocados en mandíbulas comparada con mandíbulas no irradiadas. Se realizó una búsqueda electrónica entre 2018 y 2022 en las bases de datos Medline / Pubmed, Scopus y la Web of Science, con la estrategia de búsqueda "Radiotherapy AND Dental Implants AND survival", seleccionándose solo revisiones sistemáticas con metanálisis de estudios clínicos aleatorizados y/o observacionales. Se identificaron 38 registros de los cuales luego de aplicar los criterios de elegibilidad se analizaron seis, cuyos resultados mostraron una correlación entre la radioterapia y el fracaso de implantes dentales, siendo la tasa de supervivencia del implante reportada mayor en zonas no irradiadas en comparación a zonas irradiadas. No obstante, estas diferencias entre hueso radiado y no radiado se reducen a medida que pasa el tiempo, mientras que la incidencia de efectos adversos como la osteorradionecrosis es bajo.

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Section: Resultados De Interés Principalunclassified

Section: Evaluación Metodológicaunclassified

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Radioterapia y riesgo de supervivencia en implantes dentales: Resumen de revisiones sistemáticas.

Fuentes-Barría¹,

Eguía²

2023

j.maxilo

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“…6 Therefore, oral rehabilitation treatment, including dental implant treatment, for patients who have undergone radiation therapy is known to be challenging. 7 Comparison of irradiated and non-irradiated patients who underwent dental implant treatment after oral cancer surgery showed differences in results and the presence of complications. 8 Therefore, precise evaluation of tissue healing must be considered before applying dental implants in irradiated patients.…”

Section: ⅰ Introductionmentioning

confidence: 99%

Survival Rate of Dental Implants in the Irradiated Jaw Bones of Patients with Oral and Head & Neck Malignancies

Lee¹,

Kim²,

Ahn³

2023

J Implantol Appl Sci

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Purpose: This study aimed to analyze and report the survival rate of dental implants in patients who underwent radiation therapy for head and neck malignancies.Materials and Methods: A total of 23 patients (male:female ratio = 13:10; mean age 61 years, range, 44-86 years) who underwent dental implant placement after radiation therapy between 2010 and 2020 were enrolled in this study. The cumulative survival rate (CSR) was analyzed using the Kaplan-Meier method, considering variables such as the location of the dental implant, radiation dose, and types of cancers that patients had. Implant placement was considered successful if it showed no mobility, did not cause pain or bleeding, or a minimal marginal bone level change at follow-up.Results: There were two cases of death during the follow-up period. Seven of the 83 implants failed. Among the seven failure cases, four implants were applied in the posterior mandibular area, one in the anterior mandibular area, and two in the posterior maxillary area. When each variable was considered, the CSR of the implant was 91.6%. The correlation between CSR, implant location, and the types of cancer was statistically significant. However, there was no correlation between the CSR and average radiation dose. Conclusion:The survival of implants in the irradiated area of the jaw was lower than that in the normal jawbone. The survival rate of the implants in the irradiated maxillary jaw was lower than that of the implants in the mandible. Additionally, the radiation dose was not significantly correlated with implant failure rate. Also, when compared between patients who had oral cavity cancer and other head and neck cancers, implant survival in patients with oral cavity cancer was lower than that in patients with other head and neck cancers.

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Survival of dental implants and occurrence of mucosal overgrowth in patients with head and neck cancer treated with/without radiotherapy and mucosal graft—two-year follow-up

Mattila,

Wilkman,

Avellán

et al. 2024

Clin Oral Invest

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Objectives The primary aim of the present study was to compare head and neck cancer treatment modality surgery and surgery with radiotherapy or chemoradiotherapy alone for dental implant (DI) survival. The second aim was to evaluate the prevalence of mucosal overgrowth around DI after treatment with or without mucosal grafts. Materials and methods An observational retrospective study consisted of 59 patients with malignant head and neck tumors that received DI between 2015 and 2019. Treatment modalities together with information on oral rehabilitation with DI, prevalence of mucosal overgrowth, and precursor lesions were gathered from the hospital records. Radiation doses were determined using a sum of three-dimensional dose distributions. Results Overall DI survival rate was 88%, in irritated jaw 89%, and in nonirradiated jaw 88% in this observational period (p = 0.415, mean follow-up was 2 years 10 months, range 9–82 months). Mucosal overgrowth was found in 42 of 196 implants (21%), of which 36 cases (86%) were associated in grafted areas (p < 0.001). Oral lichen planus/lichenoid reaction was diagnosed in 14 of all 59 (24%) oral cancer patients. Conclusion Implant survival was not significantly influenced by radiation therapy in this observational period. In grafted bone, implant survival was significantly inferior than in native bone. Mucosal overgrowth around implants was more common in mucosal grafted areas versus nongrafted. Clinical relevance This study demonstrates the impact of grafted bone to dental implant survival rate and mucosal overgrowth.

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Dental implants in patients with head and neck cancer—A systematic review and meta‐analysis of the influence of radiotherapy on implant survival

Cited by 23 publications

References 89 publications

Radioterapia y riesgo de supervivencia en implantes dentales: Resumen de revisiones sistemáticas.

Radioterapia y riesgo de supervivencia en implantes dentales: Resumen de revisiones sistemáticas.

Survival Rate of Dental Implants in the Irradiated Jaw Bones of Patients with Oral and Head & Neck Malignancies

Survival of dental implants and occurrence of mucosal overgrowth in patients with head and neck cancer treated with/without radiotherapy and mucosal graft—two-year follow-up

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Dental implants in patients with head and neck cancer—A systematic review and meta‐analysis of the influence of radiotherapy on implant survival

Cited by 23 publications

References 89 publications

Radioterapia y riesgo de supervivencia en implantes dentales: Resumen de revisiones sistemáticas.

Radioterapia y riesgo de supervivencia en implantes dentales: Resumen de revisiones sistemáticas.

Survival Rate of Dental Implants in the Irradiated Jaw Bones of Patients with Oral and Head &amp; Neck Malignancies

Survival of dental implants and occurrence of mucosal overgrowth in patients with head and neck cancer treated with/without radiotherapy and mucosal graft—two-year follow-up

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Product

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Survival Rate of Dental Implants in the Irradiated Jaw Bones of Patients with Oral and Head & Neck Malignancies