“…[11][12][13] Although autogenous bone grafts are currently the standard of care, bone substitute materials are extensively studied in order to avoid harvesting autogenous bone, as there are several disadvantages associated with using autogenous grafts: the additional surgical site, donor site morbidity exceeding that at the treatment site, often times insufficient volume of harvested bone, and, in dentistry, the need for general anesthesia to harvest extraoral bone. [14][15][16] Among alternative graft choices, synthetic bone substitutes are superior to freeze-dried human allografts or bovine-deproteinized bone xenografts in several respects. They excel in terms of safety profile, as there is no risk of disease transmission or immunological challenges.…”