Dental infections and atherosclerosis

Beck, James D.; Pankow, James S.; Tyroler, H. A.; Offenbacher, Steven

doi:10.1016/s0002-8703(99)70293-0

Cited by 159 publications

(134 citation statements)

References 21 publications

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“…In many epidemiological studies, periodontitis was proven to play important roles in initiation and progression of CVD, [69,70] by chronic infection on the blood vessels [20][21][22][23][24][25][26][27][28][29] or by the elevation of body�s CRP level. [29][30][31][32][33][34][35][36][37][38][39] The prevalence of chronic periodontitis was very high among populations, especially in chronic form.…”

Section: Discussionmentioning

confidence: 99%

“…[75] Chronic infection was known to be able to cause endothelial dysfunction. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] PG�s fimbriae secretes protein, called gp130, [83] which facilitate PG to invade EC and trigger celluler immune response. [84] The host will secrete TNF, [85] IL-1, IL-6, IL-10, and IL-12 [86][87][88] by TLR�s stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…[19,20] Atherosclerosis had been proven to be induced by periodontopathogen from periodontitis. [21][22][23][24][25][26][27][28] Inflammation in mouth may cause systemic inflammation, which is indicated by the elevation of CRP in the body, [29,30] which is functioned as markers, [31,32] predictors of CVD, [33,34] and may induce atherosclerosis lesions. [35][36][37][38] Focal infection in mouth may induce atherosclerosis lesions by initiate systemic and humoral immune responses.…”

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confidence: 99%

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Mechanisms of Periodontitis - Induced Atherosclerosis

Hudyono

Sunariani

2010

IJTID

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Nowadays CVD become the most common cause of death in US and worldwide. Atherosclerosis plays an important role in CVDs pathogenesis. Atherosclerosis decreases the elasticity of the vascular. Atherosclerosis shares the same risk factor as CVD, in which obesity, hyperlipidemia, hypertension and lack of physical activity may initiate it. However, 50% of all CVD patients are lack of the usual causes of CVD. The purpose of this review is to reveal the mechanism of periodontitis-induced atherosclerosis. Inflammation and autoimmune disease might play an important role in initiate the CVD. Periodontitis is one of the oral diseases which can cause systemic inflammation and may induce the atherosclerosis. Porphyromonas gingivalis (Pg) which is the major cause of periodontitis can induce it by expressing protein gp130 in its fimbriae

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Mechanisms of Periodontitis - Induced Atherosclerosis

Hudyono

Sunariani

2010

IJTID

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“…La proximidad de dichos patóge-nos con el endotelio vascular, permite que tanto bacterias como moléculas proinflamatorias accedan a la circulación a través de las capas epiteliales quienes pueden haber perdido parte de su integridad por los procesos inflamatorios e infecciosos característicos de esta entidad (42). Los patógenos periodontales han sido recientemente identificados en lesiones ateroscleróticas, quienes además de generar inflamación local poseen mecanismos que pueden afectar el balance sistémico de mediadores inflamatorios (43).…”

Section: El Amiloide a Sérico Y Su Relación Con Enfermedad Periodontalunclassified

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

Romero-Sánchez

Uribe-Rivera

Velandia-Quintero

et al. 2013

Avances en Periodoncia

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RESUMENLa respuesta de fase aguda es la reacción inflamatoria inmediata del huésped que contrarresta desafíos como lesión de los tejidos, infección y trauma. Los reactantes de fase aguda que han recibido mayor atención son: proteína C reactiva (PCR), componente sérico P, proteína amiloide sérica (AAS) y alfa 1 ácido glicoproteína. Se ha establecido en décadas pasadas que las proteínas de fase aguda no solamente aparecen en procesos de enfermedades severas y agudas si no también en condiciones crónicas. El AAS es el principal componente de las placas amiloideas secundarias depositadas en los órga-nos principales como consecuencia de la enfermedad inflamatoria crónica. La familia de la AAS contiene un número de diferentes apolipoproteínas expresadas, las cuales son sintetizadas principalmente por el hígado. El aumento de AAS es considerado un marcador sistémico de enfermedades inflamatorias agudas y enfermedades crónicas que afecta la composición y función de lipoproteínas de alta densidad (HDL). Se ha demostrado que la intervención terapéutica en la periodontitis disminuye la inflamación y reduce el AAS significativamente y por consiguiente puede reducir el riesgo de enfermedad cardiovascular (ECV). Además es posible que pacientes con periodontitis, que presentan un aumento de la PCR y el AAS, representen un subgrupo específico en términos de riesgo para la aterosclerosis y enfermedad cardiovascular en comparación a los pacientes con periodontitis cuyos niveles plasmáticos de AAS son normales, estableciendo así una relación directa entre la enfermedad periodontal y los niveles de AAS.

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“…For example, patients with cystic fibrosis, or asthma or chronic obstructive pulmonary disease (COPD) are at risk for developing additional inflammatory diseases such as diabetes (8), cardiovascular disease (CVD), and nephropathy (9) at new sites. We are also beginning to understand why patients with primary inflammatory diseases such as rheumatoid arthritis (10) and periodontal disease (11) are at risk of developing cardiovascular events. It is of special concern when life threatening diseases such as CVD, renal failure, and cancer are results of the dissemination from the local, primary inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Development of multiple complications in type 2 diabetes is associated with the increase of multiple markers of chronic inflammation

Hwang

Chou

et al. 2008

Clinical Laboratory Analysis

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Patients with type 2 diabetes (T2DM) are known at risk for developing cardiovascular disease (CVD), nephropathy, and cancer. We were interested to find out whether multiple markers associated with chronic inflammation are detectable in patients with T2DM and are increased in patients with T2DM who developed additional clinical complications. A sequence of multiple risk markers for atherogenesis, associated with chronic inflammation, was measured in patients with T2DM before and after the development of clinical complications. We found that multiple clinical complications frequently developed simultaneously in patients with T2DM. At the early stage of T2DM, only low levels and low percent elevations of multiple risk markers were detected. However, both the level and the percent elevation of these markers were found to increase with disease progression and the development of clinical complications. We believe that chronic inflammation not only contributes to the pathogenesis of T2DM but also continues to increase in T2DM patients who are developing additional clinical complications. It appears that these multiple markers are potentially useful not only for monitoring the progression of T2DM but also predicting the risk of developing macro-and microvascular disease, nephropathy, and cancer.

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Dental infections and atherosclerosis

Cited by 159 publications

References 21 publications

Mechanisms of Periodontitis - Induced Atherosclerosis

Mechanisms of Periodontitis - Induced Atherosclerosis

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

Development of multiple complications in type 2 diabetes is associated with the increase of multiple markers of chronic inflammation

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