Dental Sensory Receptors

Byers, Margaret R.

doi:10.1016/s0074-7742(08)60677-7

Cited by 302 publications

(210 citation statements)

References 162 publications

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“…Human dentin tubules taper from a diameter of about 2 μm at their pulpal end to about 0.5 μm or less peripherally and dependent on age of the individual [1–3]. It is also well known that the pulp is richly innervated with sensory afferents, mostly involved in pain mediation [4–6] and that the dentin has limited innervation, yet appears highly sensitive with patency of the dentin tubules [7]. What is less well known, however, is whether the movement of the tubule contents excites the nerve endings directly, either in the inner ends of the tubules or in the superficial pulp, or whether the odontoblasts play a role in the transduction mechanism [7].…”

Section: Introductionmentioning

confidence: 99%

Dentin hypersensitivity: pain mechanisms and aetiology of exposed cervical dentin

et al. 2012

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ObjectivesThe paper’s aim is to review dentin hypersensitivity (DHS), discussing pain mechanisms and aetiology.Materials and methodsLiterature was reviewed using search engines with MESH terms, DH pain mechanisms and aetiology (including abrasion, erosion and periodontal disease).ResultsThe many hypotheses proposed for DHS attest to our lack of knowledge in understanding neurophysiologic mechanisms, the most widely accepted being the hydrodynamic theory. Dentin tubules must be patent from the oral environment to the pulp. Dentin exposure, usually at the cervical margin, is due to a variety of processes involving gingival recession or loss of enamel, predisposing factors being periodontal disease and treatment, limited alveolar bone, thin biotype, erosion and abrasion.ConclusionsThe current pain mechanism of DHS is thought to be the hydrodynamic theory. The initiation and progression of DHS are influenced by characteristics of the teeth and periodontium as well as the oral environment and external influences. Risk factors are numerous often acting synergistically and always influenced by individual susceptibility.Clinical relevanceWhilst the pain mechanism of DHS is not well understood, clinicians need to be mindful of the aetiology and risk factors in order to manage patients’ pain and expectations and prevent further dentin exposure with subsequent sensitivity.

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Section: Introductionmentioning

confidence: 99%

Dentin hypersensitivity: pain mechanisms and aetiology of exposed cervical dentin

et al. 2012

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“…However, the continuously erupting rodent incisors exhibited significantly different pulp tissue organization compared with mature erupted teeth [16]. The injured pulp tissues of rodent incisors exhibited significantly shorter healing times compared with mature canine teeth [17], and therefore, the injury responses of rat incisors might be quite different to mature teeth.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the topical application of MMP-3 protein to the injured pulp tissues of rat incisors accelerated tissue regeneration, angiogenesis and reparative dentin formation at significantly higher rates than those observed with the control treatment [15]. However, rat incisors are continuously erupting teeth that exhibit pulp organization that is significantly different than that of mature erupted teeth [16]. Therefore, the injury responses of rat incisors might be quite specialized and unique to continuously erupting teeth.…”

Section: Introductionmentioning

confidence: 95%

Anti-Inflammatory Effects of Matrix Metalloproteinase-3 on Irreversible Pulpitis of Mature Erupted Teeth

Hira

Kobayashi²,

Kawashiri³

et al. 2014

Journal of Oral and Maxillofacial Surgery

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Matrix metalloproteinases (MMPs) are involved in extracellular matrix degradation and the modulation of cell behavior. These proteinases have also been implicated in tissue repair and regeneration. Our previous studies have demonstrated that MMP-3 elicits stimulatory effects on the proliferation and the migration of endothelial cells as well as anti-apoptotic effects on these cells in vitro. In addition, we found that MMP-3 enhanced the regeneration of lost pulp tissue in a rat incisor pulp injury model. However, continuously erupting rodent incisors exhibit significantly different pulp organization compared with mature erupted teeth. Therefore, we have further extended these studies using a canine irreversible pulpitis model to investigate the effects of MMP-3. In this study, the crowns of the canine mature premolars were removed and the pulp tissues were amputated. The amputated pulp tissues remained exposed for 24 or 72 hours to induce mild or severe irreversible pulpitis, respectively, followed by sealing of the cavities. In both models, the whole pulp tissues became necrotic by day 14. In this mild pulpitis model, the regeneration of pulp tissue with vasculature and nerves was observed until 14 days after sealing with MMP-3, followed by extracellular matrix formation in the regenerated pulp tissues until day 28. The treatment with MMP-3 resulted in a decrease in the number of macrophage and antigen-presenting cells and a significant inhibition of IL-6 expression on day 3. The inhibition of MMP-3 activity abolished these anti-inflammatory effects. Immunofluorescence staining demonstrated that MMP-3 was involved in the modification of serum-derived hyaluronanassociated proteins and hyaluronan (SHAP-HA) complexes possibly through the degradation of versican. These results demonstrate that MMP-3 can act as an anti-inflammatory agent and suggest that MMP-3 might represent a useful therapy for the treatment of mild irreversible pulpitis.

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“…Some of the Adelta fi bers may be polymodal responding to mechanical, chemical and thermal stimuli (3,4). In the tooth, these fi bers traverse the odontoblastic layer and terminate in the dentinal tubules sensitive to mechanical stimulation, and so they respond to stimuli caused by the movement of fl uid within dentinal tubules, which leads to sharp pain associated with A-delta fi ber activation (5,6). They transmit early shooting pain.…”

Section: Functional Components Of Mandibular Nerve and Their Intraneumentioning

confidence: 99%

Anatomy and clinical applications of the mandibular nerve

Somayaji¹,

Acharya²,

Mohandas³

et al. 2012

BLL

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Abstract:A thorough anatomical knowledge is very essential for clinical practice and any surgical procedure. Unfortunately anatomical variations can lead to hazards in medical and dental diagnosis and treatment. Such knowledge is very essential even in effective local anesthesia which is an essential part of treatment in patients with many oral disorders. Therefore a normal anatomy and its possible variations are utmost important aspects also in dentistry. One of the structures that dentists very often deal with is the mandibular nerve which therefore needs a thorough review. However, there are not many consolidated literature reviews available regarding its variations and clinical applications. Keeping this in mind, in this article, the authors have brought together available literature on various aspects of mandibular nerve. The fi nal review will be of benefi t to clinicians (Fig. 2 A thorough anatomical knowledge is very essential for clinical practice and any surgical procedure. The idea of exact location of various structures in the body prepares the clinician for a better approach in diagnosis and intervention. Unfortunately, the anatomical variations can lead to hazards in medical and dental diagnosis and treatment. Such knowledge is very essential even in effective local anesthesia which is an essential part of treatment in patients with many oral disorders. Therefore a normal anatomy and its possible variations are utmost important aspects also in dentistry. One of the structures that dentists very often deal with is the mandibular nerve which therefore needs a thorough review. However, there are not many consolidated literature reviews available regarding its variations and clinical applications. Keeping this in mind, in this article, the authors have brought together literature available on various aspects of mandibular nerve. The fi nal review will be of benefi t to clinicians.The mandibular nerve, largest division of trigeminal nerve, supplies the mandibular teeth and gums, mucosa of the anterior two thirds of the tongue, fl oor of the oral cavity, skin of the temporal region, part of the auricle and external acoustic meatus including the tympanum, lower lip, and lower and posterior parts of the face. Developmentally, it is the post-trematic nerve of the fi rst pharyngeal arch and therefore contains the motor fi bers to the muscles developed from the fi rst pharyngeal arch. It is a mixed nerve formed by the union of a large sensory root, branch of the lower part of the trigeminal ganglion and a smaller motor root from the pons which courses under the trigeminal ganglion. Both roots exit through the foramen ovale and unite just outside the foramen to form the trunk of the mandibular nerve which descends between the tensor veli palatini and lateral pterygoid muscles, gives off a meningeal branch and the nerve to medial pterygoid branch and ends by dividing into a smaller, mostly motor anterior branch and a larger, mostly sensory posterior branch. It contains about 78,000 myelinated fi bers. The nerve...

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Dental Sensory Receptors

Cited by 302 publications

References 162 publications

Dentin hypersensitivity: pain mechanisms and aetiology of exposed cervical dentin

Dentin hypersensitivity: pain mechanisms and aetiology of exposed cervical dentin

Anti-Inflammatory Effects of Matrix Metalloproteinase-3 on Irreversible Pulpitis of Mature Erupted Teeth

Anatomy and clinical applications of the mandibular nerve

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