Dentate gyrus−cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar <scp>II</scp> disorder: Longitudinal and cross‐sectional analyses

Elvsåshagen, Torbjørn; Zuzarte, Pedro; Westlye, Lars T.; Bøen, Erlend; Josefsen, Dag; Boye, Birgitte; Hol, Per Kristian; Malt, Ulrik Fredrik; Young, L. Trevor; Andreazza, Ana Cristina

doi:10.1111/bdi.12457

Cited by 19 publications

(16 citation statements)

References 83 publications

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“…Our results again demonstrate that there is a significant increase in oxidative stress in bipolar patients, compared to matched controls . In this study, the difference was driven by an increase in oxidized glutathione, rather than a reduction in reduced glutathione.…”

Section: Discussionsupporting

confidence: 68%

Plasma glutathione suggests oxidative stress is equally present in early‐ and late‐onset bipolar disorder

et al. 2018

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Section: Discussionsupporting

confidence: 68%

Plasma glutathione suggests oxidative stress is equally present in early‐ and late‐onset bipolar disorder

et al. 2018

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“…In this study the dentate gyrus volume was reduced before onset of plaque formation. Elvsåshagen et al [10] demonstrated, that decreased volume of the dentate gyrus was associated with depressive episodes. Longoni et al [18] studied correlation between physical activity and dentate gyrus volume in pediatric acquired demyelinating syndromes.…”

Section: Discussionmentioning

confidence: 99%

“…The gyral organization in normal human brain may vary between individuals. Thus, an understanding of the anatomical variations in the human cortex may be important for neuroanatomy teaching, diagnostic neuroimaging and for neurosurgical procedures [10,12,13,16,18,27,28]. Anatomy of the hippocampal region is thought to be very complex and difficult to understand for non-specialized neurosurgeons or neurologists [6].…”

Section: Introductionmentioning

confidence: 99%

Anatomical variations of the dentate gyrus in normal adult brain

Haładaj

2019

Surg Radiol Anat

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Recent scientific papers indicate the clinical significance of the dentate gyrus. However, a detailed knowledge of the anatomical variations of this structure in normal adult brain is still lacking. An understanding of the variable morphology of the dentate gyrus may be important for diagnostic neuroimaging. Thus, the purpose of this macroscopic cadaveric study was to describe the anatomical variations of the dentate gyrus. Forty formalin-fixed human cerebral hemispheres, obtained from bodies of donors without the history of neuropathological diseases, were included in the study. The dentate gyrus was classified as well-developed, when it protruded completely from under the fimbria of the hippocampus. The gyrus was classified as underdeveloped, when it was covered by the fimbria of the hippocampus (but clearly visible at the coronal section of the hippocampal formation), while the hypoplastic gyrus was not visible macroscopically under the fimbria of the hippocampus. The well-developed type was observed in 27 cases (67.5%). The thickness of well-developed type of the dentate gyrus, measured between the fimbriodentate sulcus and hippocampal sulcus, varied from 2.74 to 5.21 mm (mean = 3.67 mm, median = 5.54 mm, SD 0.65 mm). In the next nine cases (22.5%), the dentate gyrus was underdeveloped. The thickness of underdeveloped type of the dentate gyrus varied from 1.75 to 2.37 mm (mean = 2.02 mm, median = 2.16 mm, SD 0.33 mm). In the remaining four cases (10%), the dentate gyrus was hypoplastic and could not be distinguished macroscopically. In all injected hemispheres, arterial supply of the dentate gyrus was provided by the branches of the posterior cerebral artery. Awareness of normal variations of the dentate gyrus may allow for better correlation of anatomical knowledge with radiological data and for use this knowledge to describe abnormal conditions.

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“…In addition, high sensitivity towards AD progression at both 2-year and 6-week follow-up times was detected, using intra-individually optimized co-registration of repeated scans (Worker et al, 2018). In their report on bipolar disorder, Elvsåshagen et al (2016) reported test-retest ICC over 0.94 for 3-Tesla T1-weighted images selectively for the dentate gyrus/CA4, for within-session repeats (N=53) and two separate scanning sessions (N=21).…”

Section: Test-retest Reliability (Same Scanner)mentioning

confidence: 99%

FreeSurfer based segmentation of hippocampal subfields: a review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

Sämann¹,

Iglesias²,

Gutman³

et al. 2020

Preprint

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Structural hippocampal abnormalities are common in many neurological and psychiatric disorders, and even variation within the normal range is related to cognitive performance and other complex phenotypes such as stress sensitivity. Hippocampal subregions are increasingly studied, as automated algorithms have become available for mapping and volume quantification. In the context of the ENIGMA Consortium, several Disease Working Groups are using the FreeSurfer software to analyze hippocampal subregion (subfield) volumes in patients with major depressive disorder, bipolar disorders, posttraumatic stress disorder, and other conditions, along with data from matched controls. In this overview, we explain the algorithm’s principle, summarize measurement reliability studies, and demonstrate two additional aspects (subfield autocorrelation and volume/reliability correlation) with illustrative data. We then explain the rationale for a standardized hippocampal subfield segmentation quality control (QC) procedure for improved pipeline harmonization. To guide researchers to make optimal use of the algorithm, we discuss how global size and age effects can be modelled, how QC steps can be incorporated and how subfields may be aggregated into composite volumes. This discussion is based on a synopsis of 162 published neuroimaging studies (01/2013–12/2019) that applied the FreeSurfer hippocampal subfield segmentation in a broad range of domains including cognition and healthy aging, brain development and neurodegeneration, affective disorders, schizophrenia, childhood trauma and posttraumatic stress disorder, inflammatory and systemic disease, alcoholism, stress regulation, neurotoxicity, as well as assessments of heritability, effects of candidate genes, genome-wide association studies and epigenetic effects. Lastly, we highlight points where FreeSurfer-based hippocampal subfield studies may be optimized.

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Dentate gyrus−cornu ammonis (CA) 4 volume is decreased and associated with depressive episodes and lipid peroxidation in bipolar II disorder: Longitudinal and cross‐sectional analyses

Cited by 19 publications

References 83 publications

Plasma glutathione suggests oxidative stress is equally present in early‐ and late‐onset bipolar disorder

Plasma glutathione suggests oxidative stress is equally present in early‐ and late‐onset bipolar disorder

Anatomical variations of the dentate gyrus in normal adult brain

FreeSurfer based segmentation of hippocampal subfields: a review of methods and applications, with a novel quality control procedure for ENIGMA studies and other collaborative efforts

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