“…These inadequacies can include incomplete alteration and/or removal of smear layer components due to composition (pH, osmolality) and strength of the acidic primer, and inadequate resin film thickness, requiring multiple layering techniques and changes in the monomer/water ratio, resulting in phase separations. [1][2][3]9,16,[19][20][21][22] Morphological and histological considerations, and other clinical factors causing inadequate bonding at the material/tooth surface interface, include cavity configuration (C-factor) and dentinal tubule/enamel rod orientation, capillary movement of dentinal tubular fluids, physical characteristics of the restorative material (filler loading, volumetric expansion, modulus of elasticity and polymerization contraction), inadequate margin adaptation of the restorative material during insertion, inappropriate barrier protection (dental rubber dam), tooth location, occlusal stresses/tooth flexure and patient age considerations. [23][24][25][26][27][28][29][30][31] In this study, since hybrid layer morphology was not evaluated microscopically, the specific nature of restoration failure (microleakage) for each adhesive system is unknown, although several factors were strongly suspected: inefficiency of acidic monomers in alteration of the smear layer for classic hybrid layer formation, cavity C-factor, orientation of dentinal tubules/enamel rods to the cementoenamel junction, use of acetone-based solvent primer systems and post-treatment stresses caused by polymerization contraction.…”