Dentinogenesis

Abstract

The formation of dentin, dentinogenesis, comprises a sophisticated interplay between several factors in the tissue, cellular as well as extracellular. Dentin may be regarded as a calcified connective tissue. In this respect, as well as in its mode of formation, it is closely related to bone. Using dentinogenesis as an experimental model to study biomineralization provides several practical advantages, and the results may be extrapolated to understand similar processes in other tissues, primarily bone. After describing dentin structure and composition, this review discusses items such as the morphology of dentinogenesis; the dentinogenically active odontoblast, transport, and concentrations of mineral ions; the constituents of the dentin organic matrix; and the presumed mechanisms involved in mineral formation.

Biomimetics: lessons from nature–an overview

“…An individual tooth consists of two major parts: the crown and the root (Linde & Goldberg 1993; figure 28a). The tooth itself consists of a multilayered structure with the crown as the outer layer, the dentin layer as an intermediate layer and the pulp chamber in the core part (Schroeder 1991; figure 28b).…”

Roles of Heparan Sulfate Sulfation in Dentinogenesis

“…Dentinogenesis is regulated by sequential and reciprocal interactions with the dental epithelium mediated by epithelial-mesenchymal interactions, which direct both morphogenesis and differentiation (8 -10). Odontoblasts are characteristically columnar polarized cells, and this cytological polarization specifically occurs in a single layer adjacent to the inner dental epithelium (11). Dentin sialophosphoprotein (Dspp) is a phosphorylated parent protein that is cleaved posttranslationally into two dentin non-collagenous proteins: dentin sialoprotein (Dsp) and dentin phosphoprotein (Dpp) (12).…”

Human ex vivo dentin-pulp complex preservation in a full crown model

“…20 Predentin is an unmineralized organic matrix produced and regulated by vital odontoblasts and is a constant feature in healthy teeth. 21,22 The observation of predentin supports evidence of an active odontoblastic layer in T-groups. Expectably, in C-groups there were no predentin, since this is a serum without any nutriments.…”