Deoxypreussomerins from Jatropha curcas: are they also plant metabolites?

Ravindranath, N.; Reddy, M. Ravinder; Mahender, Gurram; Ramu, R.; Kumar, K. Praveen; Das, Biswanath

doi:10.1016/j.phytochem.2004.06.032

Cited by 53 publications

(39 citation statements)

References 13 publications

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“…These compounds were examined to possess impressive antibacterial activity against the organism Staphylococcus aureus. Their activity was comparable to that of the standard compound, penicillin G. 45 From the roots of Jatropha gossypifolia the phenolic compounds, tetradecyl-(E)-ferulate (63), ferulic acid (64) and fraxetin (65) were obtained (Figure 3). 46 The first compound (63) is a new natural product and the other two compounds (64 and 65) were reported for the first time from the species.…”

Section: Other Constituentsmentioning

confidence: 81%

“…Three deoxypreussomerins, palmarumycins JC 1 (60), JC 2 (61) and CP 1 (62), were isolated from a collection of the stem of Jatropha curcas (Table 1). 45 The first two compounds, 60 and 61 are new deoxypreussomerins while 62 is a known compound. All these compounds were characterized from spectral evidence.…”

Section: Other Constituentsmentioning

confidence: 99%

“…The X-ray crystallographic analysis of 60 was also performed. 45 The hydroxyl group at C-1 of JC-1 was oxidised to a keto group in JC-2 (61). The 1 H NMR spectrum of JC-2 showed the signal of a chelated -OH group (δ 12.27, 1H, brs).…”

Section: Other Constituentsmentioning

confidence: 99%

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Our phytochemical research on Jatropha species

Das¹,

Salvanna²,

Reddy³

et al. 2017

Arkivoc

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Jatropha is an important genus of the family Euphorbiaceae. The plants of this genus contain complex chemical constituents which are structurally impressive. The medicinal properties of the plants and their various constituents are valuable. We carried out phytochemical investigation on three Jatropha species, viz., Jatropha gossypifolia, Jatropha curcas and Jatropha multifida. We isolated several constituents: diterpenes, lignans, coumarinolignans and other compounds. Some of the isolates possess significant antibacterial and anticancer properties. Here, we discuss our phytochemical research on Jatropha species informing of the isolation, structures and bioactivity of their chemical constituents.

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Section: Other Constituentsmentioning

confidence: 81%

Section: Other Constituentsmentioning

confidence: 99%

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Our phytochemical research on Jatropha species

Das¹,

Salvanna²,

Reddy³

et al. 2017

Arkivoc

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“…Unexpectedly, instead of the ubiquitous macrocyclic polydisulfides, seven new spirodioxynaphthalene compounds, named palmarumycins BG1-BG7 (12-18) ( Figure 4), were found [17] . It is noteworthy that these intriguing compounds were generally considered to be fungal metabolites, even though there were four reports on the isolation of palmarumycins (or preussomerins) from plants [18][19][20][21] . The fact that compounds 12-18 were isolated in quite an appreciable quantity indicated that these compounds were produced by B gymnorrhiza; however, we could not rule out the possibility that they were the metabolites of an endophytic or epiphytic fungus.…”

Section: Chemical Studies On Chinese Marine Plantsmentioning

confidence: 99%

Bioactive natural products from Chinese marine flora and fauna

Zhou

Guo

2012

Acta Pharmacol Sin

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In recent decades, the pharmaceutical application potential of marine natural products has attracted much interest from both natural product chemists and pharmacologists. Our group has long been engaged in the search for bioactive natural products from Chinese marine flora (such as mangroves and algae) and fauna (including sponges, soft corals, and mollusks), resulting in the isolation and characterization of numerous novel secondary metabolites spanning a wide range of structural classes and various biosynthetic origins. Of particular interest is the fact that many of these compounds show promising biological activities, including cytotoxic, antibacterial, and enzyme inhibitory effects. By describing representative studies, this review presents a comprehensive summary regarding the achievements and progress made by our group in the past decade. Several interesting examples are discussed in detail.

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“…In continuation of our work [6][7][8][9] on the constituents of Jatropha species we examined the stems of Jatropha multifida and isolated two new macrocyclic diterpenoids, 1 and 2 along with ten known compounds. Here, we describe the isolation of these constituents and structure elucidation of the unknown compounds.…”

mentioning

confidence: 99%

New Macrocyclic Diterpenoids from Jatropha multifida

Das

Ravikanth

Laxminarayana

et al. 2009

CHEMICAL & PHARMACEUTICAL BULLETIN

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Jatropha multifida LINN (Euphorbiaceae), a shrub, is found in different parts of India. The plant is known to exhibit antibiotic activity.2) Earlier examination of the latex of the plant afforded some cyclic peptides, phenolics and glucosides. [3][4][5] However, the investigation on other parts of the plant has not yet been reported.In continuation of our work 6-9) on the constituents of Jatropha species we examined the stems of Jatropha multifida and isolated two new macrocyclic diterpenoids, 1 and 2 along with ten known compounds. Here, we describe the isolation of these constituents and structure elucidation of the unknown compounds.Compound 1 was isolated as a semi solid. Its molecular formula was deduced to be C 22 H 30 O 5 from its mass spectrum, elemental analysis and 13 C-NMR spectrum. The IR spectrum of the compound indicated the presence of carbonyl group and unsaturation. The 1 H-and 13 C-NMR spectral data of 1 ( Table 1) clearly suggested that its structure is related to that of japodagrone (3) 10) (a known constituent of Jatropha species) which has also presently been isolated from the investigated plant. All of the signals for the protons and carbons in the 1 H-and 13 C-NMR spectra respectively, were assigned from 2D NMR ( 1 H-1 H correlation spectroscopy (COSY), nuclear Overhauser effect spectroscopy (NOESY), heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bonding connectivity (HMBC)) and dis- Chemical investigation on the stems of Jatropha multifida resulted in the isolation of two new macrocyclic diterpenoids whose structures were established by extensive studies of their 1D and 2D-NMR spectra. The occurrence of ten other known compounds in this species is reported here for the first time.

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Deoxypreussomerins from Jatropha curcas: are they also plant metabolites?

Cited by 53 publications

References 13 publications

Our phytochemical research on Jatropha species

Our phytochemical research on Jatropha species

Bioactive natural products from Chinese marine flora and fauna

New Macrocyclic Diterpenoids from Jatropha multifida

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