Deoxyribonucleic Acid Characterization of a Microorganism Isolated from Infectious Thromboembolic Meningoencephalomyelitis of Cattle

Bailie, W E; Coles, Embert H.; Weide, Kenneth D.

doi:10.1099/00207713-23-3-231

Cited by 18 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ORF may extend further upstream from the sequence reported in lipoprotein (362%) (Theisen et al, 1992), and the this paper, since no stop codon was encountered. The previously determined value (37.3 O h k0.2) for total H. GC content of the entire 4-5 kb ORF is 39.3 %, which is mmnus DNA (Bailie et al, 1973). The sequence for the consistent with the published sequence of the H .…”

Section: Resultssupporting

confidence: 69%

Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus

Cole

Guiney

Corbeil

1993

Journal of General Microbiology

View full text Add to dashboard Cite

Haemophilus sornnus is a Gram-negative bacterial bovine pathogen which can cause disease or be carried asymptomatically. We previously showed that four serum-sensitive isolates from asymptomatic carriers lacked a 13.4 kb sequence of chromosomal DNA that was present in two virulent serum-resistant strains. We have since sequenced 5 kb of the 13.4 kb fragment from a serum-resistant strain, which contained an open reading frame (ORF) of at least 4.5 kb. From Western blot analysis, the ORF was shown to encode a 76 kDa protein (p76) that co-migrated with a 76 kDa H. somnus surface protein. Both the recombinant and natural p76 reacted with convalescent-phase serum from a cow in an experimental H. sornnus abortion study. The translational start site for p76 was identified by deletion analysis of subclones of the 5 kb cloned sequence. The 4.5 kb ORF contained 1-2 kb tandem direct repeats (DRs), with 65% identity between the two repeats at the protein level. The 5' DR (DR1) included the start site for the 76 kDa protein, and DR2 had a flanking inverted repeat, suggestive of an insertion-sequence-like element.

show abstract

Section: Resultssupporting

confidence: 69%

Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus

Cole

Guiney

Corbeil

1993

Journal of General Microbiology

View full text Add to dashboard Cite

show abstract

“…The results for H . somnus are in good agreement with those of Bailie et al (1973); this species, though not validly published, is associated with a characteristic disease of cattle (thromboencephalomyelitis) and its phenotypic peculiarities suggest it is a good taxon. The four strains of H. paragallinarum (including the type strain H144) produce coryza in fowls (Hinz & Kunjara, 1977) and again this, with the phenotypic properties of phenon 8, suggests it is also a good taxon.…”

Section: Discussionsupporting

confidence: 61%

Numerical Taxonomy of Haemophilus

Broom

Sneath

1981

Microbiology

View full text Add to dashboard Cite

The last appeared not to belong to the genus Haemophilus. A small proportion of strains were unclustered. Although the groupings were broadly satisfactory, they were not as sharply demarcated as phenons in comparable taxonomic studies, and the reasons for this are discussed. I N T R O D U C T I O N The genus Haemophilus was established by Winslow et al. (1917) for the influenza bacillusHaemophilus injluenzae (which was designated as type species) and several other bacteria. These small, Gram-negative rods were all obligate animal parasites, aerobic and rather fastidious in their growth requirements. For growth, H. influenzae requires X factor or haematin (Fildes, 1921) and V factor or NAD (Thjotta & Avery, 1921), and the requirement for one or both of these growth factors has been a traditional criterion for inclusion in the genus. The species were separated on growth factor requirements and the animal, host or organ attacked, but recent work (Nicolet, 1968; throws doubt on whether species can be based on these attributes. A fuller review is given by Power (1978).The genus Haemophilus lies close to Actinobacillus and Pasteurella, and the three genera may grade towards the Enterobacteriaceae. The genus is not closely associated with the Brucella-Neisseria-Moraxella area (Johnson,

show abstract

“…In the 1960s, TME was the most common infectious neurological disease seen in US feedlots. It accounted for 60.5 % of all cases in Kansas in which a diagnosis of encephalic disease was made, compared to the second most common disease (polioencephalomalacia), which was responsible for 16.9 % (Bailie 1969). A proportion of animals with neurological histophilosis present with paresis due to the major lesion(s) occurring in the spinal cord.…”

Section: Central Nervous System Diseasementioning

confidence: 99%

Histophilosis as a Natural Disease

O’Toole

Sondgeroth

2015

Current Topics in Microbiology and Immunology

View full text Add to dashboard Cite

Histophilus somni is responsible for sporadic disease worldwide in cattle and, to a lesser extent, in small ruminants, bighorn sheep (Ovis canadensis), and North American bison (Bison bison). The importance of H. somni diseases can be attributed to improved clinical and laboratory recognition, combined with the growth in intensive management practices for cattle. Although outbreaks of bovine histophilosis can occur year-round, in northern and southern hemispheres, it is most frequent in late fall and early winter. Weather, stress, dietary changes, and comingling of cattle are likely to be major triggers for outbreaks. The most frequent clinical expressions of histophilosis include undifferentiated fever, fibrinosuppurative pneumonia, encephalitis-leptomeningitis, necrotizing myocarditis, and diffuse pleuritis. Neurological disease occurs either as thrombotic meningoencephalitis (TME) or as suppurative meningitis with ventriculitis. Acute myocarditis is characteristically necrotizing and generally involves one or both papillary muscles in the left ventricular myocardium. Biofilm-like aggregates of bacteria occur in capillaries and veins in myocardium, in the central nervous system, and on endocardial surfaces. H. somni is a component of bovine respiratory disease (BRD) complex. In our experience, it is most commonly diagnosed in subacute-to-chronic polymicrobial pulmonary infections in combination with Mannheimia haemolytica, Trueperella pyogenes, Pasteurella multocida, or Mycoplasma bovis. Other, less common forms of H. somni disease present as polyarthritis/tenosynovitis, abortion with placentitis and fetal septicemia, epididymitis-orchitis, and ocular infections. It is likely that H. somni is under-recognized clinically and diagnostically. Most state and provincial laboratories in North America rely on bacterial isolation to confirm infection. The use of more sensitive detection methods on field cases of histophilosis will help resolve the pathogenesis of H. somni in natural outbreaks, and whether the disease is as common elsewhere as it is in Canada.

show abstract

Deoxyribonucleic Acid Characterization of a Microorganism Isolated from Infectious Thromboembolic Meningoencephalomyelitis of Cattle

Cited by 18 publications

References 17 publications

Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus

Molecular analysis of a gene encoding a serum-resistance-associated 76 kDa surface antigen of Haemophilus somnus

Numerical Taxonomy of Haemophilus

Histophilosis as a Natural Disease

Contact Info

Product

Resources

About