Dependence of dental status from the level of endogenous intoxication in chemical industry workers based on the oral fluid composition study

Gulyaeva, O.; Bakirov, A. B.; Чемикосова, Т. С.; Аверьянов, С. В.; Arsenina, O I; Каримова, Л К

doi:10.17116/stomat20199806118

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…It is widely accepted that the dHip and vHip are related to learning and emotion, respectively [86]. A previous study suggested that focal brain damage (post-stroke or posttraumatic) induced hippocampus lesion is essential for the onset of TBI-induced depression-like response [87].…”

Section: Discussionmentioning

confidence: 99%

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Yang

Hung

et al. 2021

Pharmaceutics

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Traumatic brain injury (TBI) is a leading cause of mortality and morbidity among the global youth and commonly results in long-lasting sequelae, including paralysis, epilepsy, and a host of mental disorders such as major depressive disorder. Previous studies were mainly focused on severe TBI as it occurs in adults. This study explored the long-term adverse effect of mild TBI in juvenile animals (mTBI-J). Male Sprague Dawley rats received mTBI-J or sham treatment at six weeks old, then underwent behavioral, biochemical, and histological experiments three weeks later (at nine weeks old). TTC staining, H&E staining, and brain edema measurement were applied to evaluate the mTBI-J induced cerebral damage. The forced swimming test (FST) and sucrose preference test (SPT) were applied for measuring depression-like behavior. The locomotor activity test (LAT) was performed to examine mTBI-J treatment effects on motor function. After the behavioral experiments, the dorsal hippocampus (dHip) and ventral hippocampus (vHip) were dissected out for western blotting to examine the expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB). Finally, a TrkB agonist 7,8-DHF was injected intraperitoneally to evaluate its therapeutic effect on the mTBI-J induced behavioral abnormalities at the early adult age. Results showed that a mild brain edema occurred, but no significant neural damage was found in the mTBI-J treated animals. In addition, a significant increase of depression-like behaviors was observed in the mTBI-J treated animals; the FST revealed an increase in immobility, and a decrease in sucrose consumption was found in the mTBI-J treated animals. There were no differences observed in the total distance traveled of the LAT and the fall latency of the rotarod test. The hippocampal BDNF expression, but not the TrkB, were significantly reduced in mTBI-J, and the mTBI-J treatment-induced depression-like behavior was lessened after four weeks of 7,8-DHF administration. Collectively, these results indicate that even a mild juvenile TBI treatment that did not produce motor deficits or significant histological damage could have a long-term adverse effect that could be sustained to adulthood, which raises the depression-like behavior in the adult age. In addition, chronic administration of 7,8-DHF lessens the mTBI-J treatment-induced depression-like behaviors in adult rats. We suggest the potential usage of 7,8-DHF as a therapeutic agent for preventing the long-term adverse effect of mTBI-J.

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Section: Discussionmentioning

confidence: 99%

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Yang

Hung

et al. 2021

Pharmaceutics

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“…Thus, the constant impact of working environment factors that have a negative impact on the body of workers can change the host's response to processes in the periodontium, increasing susceptibility to periodontal diseases, and the course and progression of the disease can become more aggressive [4].…”

Section: Discussionmentioning

confidence: 99%

“…According to WHO, 98% of the adult population of the planet have problems associated with the pathology of periodontal tissues. Over the years, there has been a trend towards an earlier onset of this disease and its aggressive course [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. The occurrence and course of periodontitis is aggravated by exposure to harmful factors of the working environment and bad habits [2,6].…”

Section: Introductionmentioning

confidence: 99%

The role of middle-weight molecules and the detoxication activity of mixed saliva albumin in the development of periodontal pathology in oil refinery workers

Bekjanova,

Miraziz

2023

E3S Web of Conf.

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“…There is evidence that the activation of LPO processes is an important pathophysiological mechanism of endogenous intoxication (Gulyaeva et al 2019). Excessive lipoperoxidation is accompanied by the accumulation of products of peroxidation and depletion of reserves of antioxidant systems.…”

Section: Discussionmentioning

confidence: 99%

Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis

Demkovych¹,

Shcherba²,

Yaremchuk³

et al. 2021

PHAR

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The article presents the results of study effect of quercetin on the indicators of endogenous intoxication syndrome under conditions of experimental periodontitis. One of the key links in the pathogenesis of any inflammatory disease, including maxillofacial area, is endogenous intoxication, an important pathophysiological mechanism of which is the activation of lipid peroxidation. The experimental animals were treated by intramuscular injections with water-soluble quercetin for 7 days. For further research the blood serum was selected in which was determined the content of middle molecular weight molecules and erythrocyte intoxication index. Excessive lipoperoxidation was accompanied by accumulation of peroxidation products and depletion of antioxidant reserves, which led to accumulation of toxic substances. That is why the study of the level of middle molecular weight molecules and erythrocyte intoxication index in simulated bacterial-immune periodontitis is a reliable criterion. Quercetin was able to reduce the expression of endogenous intoxication syndrome in experimental bacterial-immune periodontitis.

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Dependence of dental status from the level of endogenous intoxication in chemical industry workers based on the oral fluid composition study

Cited by 3 publications

References 4 publications

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Chronic Administration of 7,8-DHF Lessens the Depression-like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

The role of middle-weight molecules and the detoxication activity of mixed saliva albumin in the development of periodontal pathology in oil refinery workers

Effects of flavonol quercetin on syndrome of endogenous intoxication in experimental periodontitis

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