Dependence of the luminescent properties of thermostabilized upconversion NaYF4:Yb, Er particles on the excitation power and temperature

Sagaidachnaya, E. A.; Konyukhova, Julia G.; Kazadaeva, N. I.; Doronkina, A. A.; Yanina, Irina Yu.; Skaptsov, Alexander A.; Pravdin, Alexander B.; Kochubey, Vyacheslav I.

doi:10.1117/1.oe.59.6.061609

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…The UCNPs samples saturated at laser powers greater than 5% of maximum laser power, which due to the focused excitation beam, corresponded to an approximate power at the focal spot of 2150 W cm −2 . This is similar to saturation processes observed for other upconversion materials [61][62][63].…”

Section: Resultssupporting

confidence: 87%

Low-temperature open-air synthesis of PVP-coated NaYF ₄ :Yb,Er,Mn upconversion nanoparticles with strong red emission

2022

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Cubic (α-phase) NaYF 4 :Yb,Er upconversion nanoparticles (UCNPs) are uniquely suited to biophotonics and biosensing applications due to their near-infrared excitation and visible red emission ( λ ex approx. 660 nm), enabling detection via thick overlying tissue with no bio-autofluorescence. However, UCNP synthesis typically requires high temperatures in combination with either high pressure reaction vessels or an inert atmosphere. Here, we report synthesis of α-phase NaYF 4 :Yb,Er,Mn UCNPs via the considerably more convenient PVP40-mediated route; a strategy that requires modest temperatures and relatively short reaction time (160°C, 2 h) in open air, with Mn 2+ co-doping serving to greatly enhance red emission. The optimal Mn 2+ co-doping level was found to be 35 mol %, which decreased the average maximum UCNP Feret diameter from 42 ± 11 to 36 ± 15 nm; reduced the crystal lattice parameter, a , from 5.52 to 5.45 Å; and greatly enhanced UCNP red/green emission ratio in EtOH by a factor of 5.6. The PVP40 coating enabled dispersal in water and organic solvents and can be exploited for further surface modification (e.g. silica shell formation). We anticipate that this straightforward UCNP synthesis method for producing strongly red-emitting UCNPs will be particularly beneficial for deep tissue biophotonics and biosensing applications.

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Section: Resultssupporting

confidence: 87%

Low-temperature open-air synthesis of PVP-coated NaYF ₄ :Yb,Er,Mn upconversion nanoparticles with strong red emission

2022

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“…To obtain an in vitro mixed suspension with a given concentration of cells and NPs, we used a suspension in a physiological solution of synthesized NaYF4:Yb,Er NPs with an average size of 80 nm (Figure 1). Four types of NPs were used: Type 1.-Synthesized NaYF4 particles "as is", coated with citrate anions as the synthesis was performed out using sodium citrate; Type 2.-NaYF4 particles annealed at a temperature of 500°С to remove citrate anions from the surface [24]; Type Type 1.-Synthesized NaYF 4 particles "as is", coated with citrate anions as the synthesis was performed out using sodium citrate; Type 2.-NaYF 4 particles annealed at a temperature of 500 • C to remove citrate anions from the surface [24]; Type 3.-NaYF 4 particles coated with SiO 2 [34]; Type 4.-NaYF 4 particles coated with HSA molecules and Methylene Blue.…”

Section: Rbc Studiesmentioning

confidence: 99%

NaYF4: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells

Doronkina,

Kochubey,

Maksutova

et al. 2023

Photonics

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(1) Background: Upconversion nanoparticles (UCNPs) are a promising tool for biological tissue structure visualization and photodynamic therapy (PDT). The luminescence of such NPs is excited in the spectrum’s near-infrared (NIR) region, while the NPs luminesce in the visible region. Conjugating such NPs with photodynamic dyes that absorb their luminescence makes it possible to increase the depth at which PDT is performed. (2) Methods: We conducted a comprehensive study on the possibility of using NaYF4:Er:Yb UCNPs in vivo for imaging and PDT. The NPs were synthesized by a hydrothermal method. The synthesis of NPs with a size of 80 nm and hexagonal structure was demonstrated. (3) Results: The accumulation of NPs in organs after their intravenous injection into rats was studied. The effect of NPs on the shape, size, and degree of aggregation of red blood cells (RBC) was also investigated. (4) Conclusions: The possibility of luminescent visualization of NPs in histological sections and their subcutaneous distribution is demonstrated. All investigated particles showed moderate toxicity, causing mostly reversible changes.

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Upconversion Nanoparticles for Cancer Therapy

Chen

2022

Advanced NanoBiomed Research

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Lanthanide‐doped upconversion nanoparticles (UCNPs) are anti‐Stokes emitters, which can produce higher‐energy ultraviolet/visible and near‐infrared (NIR) luminescence when excited with low‐energy NIR light. They are featured with nonphotobleaching, sharp emission peaks, superstability, low toxicity, low imaging background, and functional multimodality. These characteristics endow them to be useful as nanoprobes for diagnostic applications and imaging‐guided cancer therapy. Importantly, the ability to convert tissue‐penetrating NIR light into visible and ultraviolet range can expedite Fenton‐ or Fenton‐based processes in chemical dynamic therapy (CDT), activate photosensitizers (PSs) to produce singlet oxygen in photodynamic therapy (PDT), and regulate light‐controlled drug delivery processes for efficacious cancer therapy. The past decade witnessed fast progress of UCNPs as agents in single‐mode therapy or combined therapies in the forefront researches on fighting cancer. This review summarizes the fundamental roles of UCNPs in cancer therapy, highlights types of cell deaths induced by excessive reactive oxygen species (ROS), and showcases cutting‐edge applications in combined cancer therapies as well as imaging‐guided cancer therapy. Challenges and outlook on the use of UCNPs for future directions in cancer therapy are also discussed.

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Dependence of the luminescent properties of thermostabilized upconversion NaYF4:Yb, Er particles on the excitation power and temperature

Cited by 3 publications

References 36 publications

Low-temperature open-air synthesis of PVP-coated NaYF ₄ :Yb,Er,Mn upconversion nanoparticles with strong red emission

Low-temperature open-air synthesis of PVP-coated NaYF ₄ :Yb,Er,Mn upconversion nanoparticles with strong red emission

NaYF4: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells

Upconversion Nanoparticles for Cancer Therapy

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Dependence of the luminescent properties of thermostabilized upconversion NaYF4:Yb, Er particles on the excitation power and temperature

Cited by 3 publications

References 36 publications

Low-temperature open-air synthesis of PVP-coated NaYF 4 :Yb,Er,Mn upconversion nanoparticles with strong red emission

Low-temperature open-air synthesis of PVP-coated NaYF 4 :Yb,Er,Mn upconversion nanoparticles with strong red emission

NaYF4: Yb,Er Upconversion Nanoparticles for Imaging: Effect on Red Blood Cells

Upconversion Nanoparticles for Cancer Therapy

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Low-temperature open-air synthesis of PVP-coated NaYF ₄ :Yb,Er,Mn upconversion nanoparticles with strong red emission

Low-temperature open-air synthesis of PVP-coated NaYF ₄ :Yb,Er,Mn upconversion nanoparticles with strong red emission