Dependence of the quality of SALDI TOF MS analysis on the TiO2 nanocrystals’ size and shape

Popović, Iva; Milovanović, Dubravka; J, Miletić; Nešić, Maja D.; Vranješ, M.; Šaponjić, Zoran; Petković, Marijana

doi:10.1007/s11082-016-0413-5

Cited by 11 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TiO 2 nanocrystals with various shapes and sizes, such as the colloidal TiO 2 NPs, TiO 2 prolate nanospheroids (TiO 2 PNSs), and TiO 2 nanotubes (TiO 2 NTs), were investigated as matrix of LDI-TOF MS for quantitative analysis of small molecules [ 69 , 70 ]. Results showed that the applicability of individual TiO 2 nanocrystals depended on the analyte, such as all TiO 2 nanocrystals, regardless of their shape, have great potential for the detection and determination of steroid hormones, amino acids and saccharides with good detection limits.…”

Section: Nanomaterial-assisted Ldi Methods Developmentmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

View full text Add to dashboard Cite

Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds.

show abstract

Section: Nanomaterial-assisted Ldi Methods Developmentmentioning

confidence: 99%

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Yang

et al. 2017

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…All of the test samples were detected with nanotubes, particularly in negative ion mode. With carbohydrates, it was shown that the size and shape of nanocrystals influenced the way the carbohydrates packed onto the target plate, and thus affected homogeneity and reproducibility of the analysis (Popović et al, 2016a).…”

Section: Matricesmentioning

confidence: 99%

Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

Harvey

2021

Mass Spectrometry Reviews

View full text Add to dashboard Cite

This review is the ninth update of the original article published in 1999 on the application of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2016. Also included are papers that describe methods appropriate to analysis by MALDI, such as sample preparation techniques, even though the ionization method is not MALDI. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation and arrays. The second part of the review is devoted to applications to various structural types such as oligo‐ and poly‐saccharides, glycoproteins, glycolipids, glycosides and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions and applications to chemical synthesis. The reported work shows increasing use of combined new techniques such as ion mobility and the enormous impact that MALDI imaging is having. MALDI, although invented over 30 years ago is still an ideal technique for carbohydrate analysis and advancements in the technique and range of applications show no sign of deminishing. © 2020 Wiley Periodicals, Inc.

show abstract

“…Regarding the morphological properties of nanostructures, two main aspects received attention, namely shape and surface roughness [ 54 , 64 , 69 , 79 , 83 , 84 , 85 , 86 ]. In particular, the role of different shapes (spheres, rods, and stars) of AuNPs [ 75 ] as well as the role of morphology of Pd [ 79 ] ( Figure 9 ) and Pt nanostructured materials [ 87 , 88 ] were investigated.…”

Section: Other Aspects Influencing Desorption/ionization Mechanismmentioning

confidence: 99%

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

et al. 2017

View full text Add to dashboard Cite

Nanomaterials are frequently used in laser desorption ionization mass spectrometry (LDI-MS) as DI enhancers, providing excellent figures of merit for the analysis of low molecular weight organic molecules. In recent years, literature on this topic has benefited from several studies assessing the fundamental aspects of the ion desorption efficiency and the internal energy transfer, in the case of model analytes. Several different parameters have been investigated, including the intrinsic chemical and physical properties of the nanophase (chemical composition, thermal conductivity, photo-absorption efficiency, specific heat capacity, phase transition point, explosion threshold, etc.), along with morphological parameters such as the nanophase size, shape, and interparticle distance. Other aspects, such as the composition, roughness and defects of the substrate supporting the LDI-active nanophases, the nanophase binding affinity towards the target analyte, the role of water molecules, have been taken into account as well. Readers interested in nanoparticle based LDI-MS sub-techniques (SALDI-, SELDI-, NALDI- MS) will find here a concise overview of the recent findings in the specialized field of fundamental and mechanistic studies, shading light on the desorption ionization phenomena responsible of the outperforming MS data offered by these techniques.

show abstract

Dependence of the quality of SALDI TOF MS analysis on the TiO2 nanocrystals’ size and shape

Cited by 11 publications

References 8 publications

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

Analysis of Carbohydrates and Glycoconjugates by Matrix‐assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2015–2016

Mechanisms of Nanophase-Induced Desorption in LDI-MS. A Short Review

Contact Info

Product

Resources

About