Dependence of the severity of haloperidol catalepsy on the activity of dopaminergic and glutamatergic systems of the brain of rats with prolonged use of antipsychotics

Baturina, Mariya; Beyer, Eduard; Baturin, Vladimir; Попов, А. В.

doi:10.14300/mnnc.2020.15073

Cited by 3 publications

(3 citation statements)

References 11 publications

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“…Показано, что у больных шизофренией увеличено количество аутоантител к дофаминовым и NMDA-рецепторам [4]. Ранее нами было установлено, что длительное введение антипсихотических средств (галоперидол, рисперидон) крысам также может существенно повышать уровни аутоантител к дофаминовым рецепторам, NMDA-рецепторам, дофамину, белку S100 [2]. В связи с этим было выдвинуто предположение о вовлечении аутоиммунных механизмов в реализацию фармакологического действия психотропных препаратов.…”

Section: актуальностьunclassified

Possible autoimmune mechanisms of regulation of rat behavior in the “open field” test

Baturin¹,

Beyer²,

Baturina³

2023

Psychopharmacology & biological narcology

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BACKGROUND: In recent years, researchers have demonstrated interest in the autoimmune mechanisms of regulation of physiological processes. In response to damage or protein expression, the levels of autoantibodies increased to ensure the restoration of the disturbed balance. Levels of autoantibodies are high in many diseases. AIM: The aim of this study was to assess the levels of autoantibodies in the blood serum of experimental animals and evaluate their behavior in the open field test. MATERIALS AND METHODS: Of 32 male rats, two groups were formed: group 1 was not exposed to stress, whereas group 2 was subjected to stress for 7 days by applying a clamp on the skin fold for 15 min daily. Three days after the last stress procedure, testing was conducted in the open field. After assessing the behavior, blood serum was obtained, and the levels of autoantibodies to dopamine receptors (DR1 and DR2) and NMDA receptors (NR1, NR2A, and NR2B) were determined. RESULTS: Compared with group 1, group 2 visited the central zones of the field less often, had lower vertical activity, and less often performed acts of washing. In group 2, the levels of autoantibodies to DR1 and DR2 were higher, but to NR2B were lower. Correlation analysis revealed that in group 2, the level of autoantibodies to DR2 was associated with horizontal activity (r = 0.60). In group 1, a relationship was established between the level of autoantibodies to NR2B and the number of runs through the central zones of the field (r = +0.68). CONCLUSIONS: Taking into account the revealed relationship between the levels of autoantibodies and activity in the open field, the degree of increase in blood IgG titers to DR2 receptors may reflect the severity of changes in the behaviors of animals under stress. Conversely, in connection with the emerging data on the possibility of IgG penetration through the bloodbrain barrier, the effect of autoantibodies on brain dopamine receptors with a limited activity of the dopaminergic system may be considered.

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Section: актуальностьunclassified

Possible autoimmune mechanisms of regulation of rat behavior in the “open field” test

Baturin¹,

Beyer²,

Baturina³

2023

Psychopharmacology & biological narcology

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“…There has previously been a marked increase in levels of autoantibodies to NMDA and dopamine receptors during prolonged administration of antineuroleptics in rats [8], so it was interesting to study the influence of dopaminergic transmission enhancers -antiparkinson drugs, including in combination with haloperidol at levels of autoantibodies to these receptors, which was the purpose of this study.…”

Section: T He Autoimmune Concept Of Schizophrenia [1 2] Has Been Well...mentioning

confidence: 99%

Influence of chronic administration of antiparkinson drugs on levels of serum autoantibodies to dopamine and NMDA receptors

Baturina¹,

Beyer²,

Zhurbin³

et al. 2022

Medical news of the North Caucasus

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In experiments on 108 rats, changes in the level of serum autoantibodies to NMDA receptors (subunits NR1, NR2A, NR2B) and dopamine receptors of the first and second types (DR1 and DR2) were studied during chronic intraperitoneal administration of antipsychotics, antiparkinsonian drugs and their combination. The highest values of autoantibodies to NR1 and NR2A subunits were revealed when bromocriptine was used and to NR2B -when amantadine was administered. Chronic administration of haloperidol at a dose of 0.5 mg/kg increased serum levels of autoantibodies to NMDA receptors, especially in the NR2A subunit. At a dose of 0.1 mg/kg, haloperidol increased the content of autoantibodies to DR1 dopamine receptors. The use of an antipsychotic in combination with antiparkinsonian drugs led to an even more significant increase in the levels of autoantibodies to NR1, NR2A, DR1 and DR2, especially with the combined administration of bromocriptine and haloperidol. At the same time, haloperidol prevented the increase in autoantibodies to NR2B caused by antiparkinsonian drugs. The isolated use of haloperidol or bromocriptine, as well as their joint administration, increased the level of autoantibodies to the S100B protein in the blood serum, and amantadine eliminated this increase in autoantibodies. An increase in the concentration of autoantibodies to the S100B protein correlated with a high content of autoantibodies to NR1 and NR2A, as well as low content of NR2B.

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“…Обнаруженное повышение уровня белка S100 в крови и аутоантител к нему после длительного введения нейролептиков, очевидно, обусловлено активацией нейроглии в ответ на повреждение нейронов головного мозга при изменении баланса нейромедиаторных систем [9,10]. Кроме того, показана способность нейролептиков модулировать уровень NMDA-рецепторов в переднем мозге крыс [11,12]. Важно, что чрезмерная стимуляция NMDA-рецепторов возбуждающими аминокислотами, в первую очередь глутаматом, может вызвать явление, известное как эксайтотоксичность с активацией окислительного стресса и необратимой гибелью нейронов [13].…”

unclassified

Effect of neuroleptics chronic administration on the content of protein s100 in blood and the level of autoantibodies to it in rats

Baturina¹,

Beyer²,

Zhurbin³

et al. 2020

Medical news of the North Caucasus

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Dependence of the severity of haloperidol catalepsy on the activity of dopaminergic and glutamatergic systems of the brain of rats with prolonged use of antipsychotics

Cited by 3 publications

References 11 publications

Possible autoimmune mechanisms of regulation of rat behavior in the “open field” test

Possible autoimmune mechanisms of regulation of rat behavior in the “open field” test

Influence of chronic administration of antiparkinson drugs on levels of serum autoantibodies to dopamine and NMDA receptors

Effect of neuroleptics chronic administration on the content of protein s100 in blood and the level of autoantibodies to it in rats

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