Dependence of ventricular distensibility on filling of the opposite ventricle

Taylor, RR; Covell, JW; Eh, Sonnenblick; Ross, Jr J

doi:10.1152/ajplegacy.1967.213.3.711

Cited by 388 publications

(141 citation statements)

References 15 publications

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“…An increased distension of either ventricle during diastole has been shown to alter the compliance and geometry of the opposite ventricle by either a direct mechanical effect (displacement of the septum) or some other indirect process 20. The right and left ventricles share common muscle bundles, septum and pericardium 20-22.…”

Section: Discussionmentioning

confidence: 99%

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Effect of systemic hypertension on right ventricular morphology and function

Akintunde

Akinwusi²,

Familoni³

et al. 2010

CardioVascular Journal of Africa

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BackgroundHypertension is an important cardiovascular risk factor worldwide. It is associated with left ventricular hypertrophy (LVH). Both diastolic and systolic dysfunction may occur in hypertensive heart disease. The ventricles are structurally and functionally interdependent on each other. This was an echocardiographic study intended to describe the impact of left ventricular pressure overload and hypertrophy due to hypertension on right ventricular morphology and function.MethodsOne hundred subjects with systemic hypertension and 50 age- and gender-matched normotensive control subjects were used for this study. Two-dimensional (2-D), M-mode and Doppler echocardiographic studies were done to evaluate the structure and function of both ventricles. Data analysis was done using the SPSS 16.0 (Chicago, Ill). Statistical significance was taken as p < 0.05.ResultsAge and gender were comparable between the two groups. Hypertensive subjects had significantly increased left ventricular end-diastolic dimensions, posterior wall thickness, interventricular septal thickness, left atrial dimensions and left ventricular mass and index. The mitral valve E/A ratio was reduced among hypertensive subjects when compared to normal controls (1.15 ± 0.75 vs 1.44 ± 0.31, respectively; p < 0.05). A similar pattern was found in the tricuspid E/A ratio (1.14 ± 0.36 vs 1.29 ± 0.30, respectively; p < 0.05). Hypertensive subjects also had reduced right ventricular internal dimensions (20.7 ± 8.0 vs 23.1 ± 3.1 mm, respectively; p < 0.001) but similar peak pulmonary systolic velocity. The mitral e/a ratio correlated well with the tricuspid e/a ratio.ConclusionSystemic hypertension is associated with right ventricular morphological and functional abnormalities. Right ventricular diastolic dysfunction may be an early clue to hypertensive heart disease.

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Section: Discussionmentioning

confidence: 99%

“…The right and left ventricles share common muscle bundles, septum and pericardium 20-22. The mechanisms of ventricular interaction are unknown but may relate to restriction of ventricular filling by the pericardium,23 although most work has assessed only the effect of RV volume expansion on LV function,24 rather than vice versa.…”

Section: Discussionmentioning

confidence: 99%

Effect of systemic hypertension on right ventricular morphology and function

Akintunde

Akinwusi²,

Familoni³

et al. 2010

CardioVascular Journal of Africa

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“…Another possible mechanism might be an enhancement of diastolic interaction between the ventricles. Because of an anatomical association established by the interventricular septum and common muscle bundle surrounding both ventricles, an increase in one ventricular volume would modify the opposite ventricular diastolic properties (Taylor et al 1967;Bemis et al 1974;Elzinga et al 1974). In addition, it has been postulated that this diastolic interaction between the two ventricles would be enhanced by the pericardium (Janicki and Weber 1978; Spadaro et al 1979Spadaro et al , 1981Shirato et al 1982).…”

Section: Discussionmentioning

confidence: 99%

Significance of the Right Ventricular Free Wall in Dogs with and without Pulmonary Constriction.

Munakata

Shirato

Ishikawa

et al. 1995

Tohoku J. Exp. Med.

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M., KANAZAWA, M., HANEDA, T. and TAKISHIMA, T. Significance of the Right Ventricular Free Wall in Dogs with and without Pulmonary Constriction. Tohoku J. Exp. Med., 1995, 177 (2), [93][94][95][96][97][98][99][100][101][102][103][104][105][106] To evaluate the role of the right ventricular (RV) free wall in cardiac function, RV and left ventricular (LV) wall segment lengths were measured by ultrasonic crystals in 10 open chest dogs with the pericardium preserved. Right coronary artery (RCA) was perfused separately by own blood and the flow was reduced stepwise until active shortening (aL) of the RV segment disappeared or RCA flow became zero (Ischemia). The experiment was repeated with and without pulmonary stenosis (PS). At Ischemia, RV and LV systolic pressures decreased. RV end-diastolic length increased and RVaL decreased. LV enddiastolic length and LVaL were reduced. LV stroke volume concurrently fell. These changes became more prominant with PS. The critical level of RCA flow, at which RVaL began to change, was higher with PS (5.27±2.85 ml/min, mean± S.D.) than without PS (1.44± 1.16, p <0.01). Based on the relationships between RVaL and percent changes in RV developed pressure and stroke volume, the degree of the decreases in RV developed pressure and stroke volume at RVAL of zero were estimated to be about 20%. These results indicate that the RV free wall partly contributes to maintaining the RV function, especially during RV pressure overload, critical coronary flow; pressure load; right ventricular function; stroke volumeThe significance of the right ventricular free wall in cardiac function has long been questioned. Following a report by Starr et al. (1943), the right ventricular free wall has been thought not to participate in maintaining cardiac function. In contrast, right ventricular infarction sometimes shows a severely depressed state of cardiac function in the clinical settings (Cohn et al. 1974;Coma-Canella et al. 1979;Lorell et al. 1979;Coma-Canella and Lopez-Sendon 1980;Lloyd et al. 1981;Lopez-Sendon et al. 1981). In addition, the right ventricular stroke volume is known to be mainly maintained by bellows action, which consists of the cooperative movements of both the right ventricular free wall and the interventricular septum (Rushmer et al. 1953). Thus, it appears that the right ventricular free wall partly contributes to maintaining right ventricular function. Therefore, the present study was designed to clarify the significance of the right ventricular free wall in cardiac function. We induced a depression of right ventricular free wall function through the stepwise reduction in right coronary artery flow, and examined the changes in cardiac function, especially changes in the right ventricular developed pressure and left ventricular stroke volume in relation to the right ventricular free wall movement, under conditions with and without pulmonary stenosis. MATERIALS AND METHODS Surgical preparationsTen mongrel dogs weighing from 13.6 to 23.5 kg (mean 17.9 kg) were anesthetized with intra...

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“…Because left ventricular mass is a common predictor to left and right atrial performance the same anatomical framework can be regarded as a reasonable mechanism of interdependence of the left and right heart. 7,21,22 …”

Section: Changes In Right Atrial Function In Hypertensive Patientsmentioning

confidence: 99%

Right atrial function in hypertensive patients: effects of antihypertensive therapy

Dernellis¹

2001

J Hum Hypertens

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Objectives: The effects (16 weeks) of oral antihypertensive drugs on right atrial (RA) function were evaluated by two-dimensional and Doppler echocardiography in 64 patients with mild-to-moderate essential hypertension. Thirty-two age-and sex-matched normal subjects served as controls. Background: Hypertension alters the diastolic properties of the left ventricle and disturbs the left atrial contractile activities. RA performance may also alter in essential hypertension. Methods: From the tricuspid flow velocity curves the E/A ratio, the velocity-time integrals (Ei and Ai, respectively) as well as the sum, TTi ‫؍‬ Ei ؉ Ai, were measured. RA active contribution (RAAC) was expressed as the ratio RAAC ‫؍‬ Ai/TTi. Results: RA-A/E ratio, RA-Ai and RAAC were increased while RA-TTi were decreased in hypertensives compared to controls, P Ͻ 0.0001 for all comparisions. After

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Dependence of ventricular distensibility on filling of the opposite ventricle

Cited by 388 publications

References 15 publications

Effect of systemic hypertension on right ventricular morphology and function

Effect of systemic hypertension on right ventricular morphology and function

Significance of the Right Ventricular Free Wall in Dogs with and without Pulmonary Constriction.

Right atrial function in hypertensive patients: effects of antihypertensive therapy

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