Dependency of energy loss on strain rate, strain magnitude and preload: Towards development of a novel biomarker for aortic aneurysm dissection risk

Searching for a physiologically meaningful parameter for aortic biomechanics—is energy loss the way?

“…Contrary to what the authors mentioned, energy loss has been tested under both supraphysiological and physiological displacement/loads. 3 Notably, we showed that energy loss is relatively insensitive to a wide range of loading conditions, including strain rate, starting and maximum strain, and strain ratios. 3 This is exciting, as it supports the robustness of energy loss to be measured in vivo for clinical translation.…”

“…Energy loss correlated better than LTM and TZ O in the circumferential direction; data were more limited in the axial direction making conclusions less clear. Previously, energy loss was shown to also correlate strongly with delamination strength, 3 , 4 which measures the forces to peel apart the aortic wall as occurs during aortic dissection. Therefore, rupture strength is the second failure criteria that energy loss correlates well with.…”

Existing and Emerging Approaches to Risk Assessment in Patients with Ascending Thoracic Aortic Dilatation

“…Energy loss is the measure of the Windkessel function. Recently, the biomechanics of normal, dilated, and dissecting ascending aortas were studied via destructive testing [ 34 , 35 ]. The energy loss under the biaxial tensile loading was shown to be independent of the strain rate, strain magnitude, and strain pre-load over a wide range of physiological values except at the low-strain regions.…”

“…Energy loss may be considered a biomarker of aortic dissection risk in patients with ascending aortic aneurysms. [ 34 , 35 ].…”

Reply from authors: Toward physiologically meaningful biomechanical parameters from ex vivo biaxial testing

“…Our research group is cautiously optimistic about energy loss as presented by Chung and colleagues. 3 We are very excited to see the rigorous analysis conducted by Tang and colleagues 1 , 4 on sensitivity of energy loss as well as the meaningful discussion on the physics behind this parameter. Studies like the one by Tang and colleagues 4 raise our confidence in using this parameter in the future.…”