Dependent signal quenching and enhancing triggered by bipedal DNA walker for ultrasensitive photoelectrochemical biosensor

Highly Sensitive Photoelectrochemical Biosensor Based on Quantum Dots Sensitizing Bi2Te3 Nanosheets and DNA-Amplifying Strategies

“…Photoelectrochemical (PEC) bioassay as a thriving analytical technique displays the merits of sensitive response, stable signal intensity, and time-saving operation. − Generally, PEC assay monitors and reflects the photoinduced current signal in real time; therefore, the photoactive material that generates photocurrent plays an important role in promotion of analysis performance of PEC systems. − Up to now, various photoactive materials such as TiO 2 , − fullerene, , BiOI, , and graphene have been extensively investigated in the fabrication of PEC biosensors. Although encouraging effects in PEC signal output were achieved, limited light absorption or the gapless nature may impede their widespread applications .…”

DNA Walkers for Biosensing Development

“…For instance, Zhu et al designed an ultrasensitive photoelectrochemical (PEC) biosensor based on bipedal DNA walker. [82] In this work, bipedal DNA walker was used to change the distance of ferrocene (Fc) and methylene blue (MB) to the photoactive material perylene-3,4,9,10-tetracarboxylic acid (PTCA), which originally showed a high PEC signal. Upon the Fc labeled hairpin DNA 1 (H1-Fc) anchored on the surface, a significant signal reduction occurred.…”

Efficiency of Nanomaterials for Electrochemical Diagnostics based Point-of-Care Detection of Non-Invasive Oral Cancer Biomarkers

“…Incorporating the light source as excitation segment and electrochemical workstation as a recognition framework, PEC claims more points of interest, for example, positive versatility, low foundation signal, quick reaction, high affectability, and exactness [163,164]. Investigation revealed that a photoelectrochemical (PEC) biosensor for the detection of ORAOV1 in saliva samples was also fabricated.…”