Dépistage du cancer du sein des femmes à risque moyen et trajectoires de soins

Lefeuvre, D.; Catajar, Nathalie; Bihan-Benjamin, Christine Le; Bels, Frédéric De; Viguier, Jérôme; Bousquet, Philippe

doi:10.1016/j.respe.2018.01.050

Cited by 2 publications

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“…The earlier breast cancer is detected, the greater the chances of recovery. For a breast cancer detected at an early stage, 5-year survival is 99%, and 27% for a metastatic cancer 1 . The difference in the detection stage also influences the cost of medical care 2 .…”

Section: Introductionmentioning

confidence: 99%

Towards a Personalized Organized Screening in Breast Cancer : Practical Determination of Thresholds of Risk in Women at Average-Risk

Bonnet

Daurès

Landais

2021

Preprint

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In France, more than 10 million women at ”average” risk of breast cancer (BC), are included in the organized BC screening. Existing predictive models of BC risk are not adapted to the French population. Thus, we set up a new score in the French Hérault region and looked for a graded level of risk in women at "average" risk. We recruited a retrospective cohort of women, aged 50 to 60, who underwent the organized BC screening, and included 2241 non-cancer women and 527 who developed a BC during a 12-year follow-up period (2006-2018). The risk factors identified were high breast density (ACR BI-RADS grading)(B vs A: HR 1.41, 95%CI [1.05; 1.9], p=0.023; C vs A: HR=1.65 [1.2; 2.27], p=0.02 ; D vs A: HR=2.11 [1.25;3.58],p=0.006), a history of maternal breast cancer (HR=1.61 [1.24; 2.09], p < 0.001), and socioeconomic difficulties (HR 1.23 [1.09; 1.55], p=0.003). While early menopause (HR=0.36 [0.13; 0.99], p=0.003) and an age at menarche after 12 years (HR=0.77 [0.63; 0.95], p=0.047) were protective factors. We identified 3 groups at risk: lower, average, and higher, respectively. A low threshold was characterized at 1.9% of risk and a high threshold at 4.5%. Mean risks in the 3 groups of risk were 1.37%, 2.68%, and 5.84%, respectively. Thus, 12% of women presented a level of risk different from the average risk group, corresponding to 600,000 women involved in the French organized BC screening, enabling to propose a new strategy for performing an organized and personalized national BC screening.

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Section: Introductionmentioning

confidence: 99%

Towards a Personalized Organized Screening in Breast Cancer : Practical Determination of Thresholds of Risk in Women at Average-Risk

Bonnet

Daurès

Landais

2021

Preprint

View full text Add to dashboard Cite

show abstract

Determination of thresholds of risk in women at average risk of breast cancer to personalize the organized screening program

Bonnet

Daurès

Landais

2021

Sci Rep

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In France, more than 10 million women at ”average” risk of breast cancer (BC), are included in the organized BC screening. Existing predictive models of BC risk are not adapted to the French population. Thus, we set up a new score in the French Hérault region and looked for subgroups at a graded level of risk in women at ”average” risk. We recruited a retrospective cohort of women, aged 50 to 60, who underwent the organized BC screening, and included 2241 non-cancer women and 527 who developed a BC during a 12-year follow-up period (2006-2018). The risk factors identified were high breast density (ACR BI-RADS grading)(B vs A: HR = 1.41, 95%CI [1.05; 1.9], p = 0.023; C vs A: HR = 1.65 [1.2; 2.27], p = 0.02 ; D vs A: HR = 2.11 [1.25;3.58], p = 0.006), a history of maternal breast cancer (HR = 1.61 [1.24; 2.09], p < 0.001), and socioeconomic difficulties (HR 1.23 [1.09; 1.55], p = 0.003). While early menopause (HR = 0.36 [0.13; 0.99], p = 0.003) and an age at menarche after 12 years (HR = 0.77 [0.63; 0.95], p = 0.047) were protective factors. We identified 3 groups at risk: lower, average, and higher, respectively. A low threshold was characterized at 1.9% of 12-year risk and a high threshold at 4.5% 12-year risk. Mean 12-year risks in the 3 groups of risk were 1.37%, 2.68%, and 5.84%, respectively. Thus, 12% of women presented a level of risk different from the average risk group, corresponding to 600,000 women involved in the French organized BC screening, enabling to propose a new strategy to personalize the national BC screening. On one hand, for women at lower risk, we proposed to reduce the frequency of mammograms and on the other hand, for women at higher risk, we suggested intensifying surveillance.

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Dépistage du cancer du sein des femmes à risque moyen et trajectoires de soins

Cited by 2 publications

References 0 publications

Towards a Personalized Organized Screening in Breast Cancer : Practical Determination of Thresholds of Risk in Women at Average-Risk

Towards a Personalized Organized Screening in Breast Cancer : Practical Determination of Thresholds of Risk in Women at Average-Risk

Determination of thresholds of risk in women at average risk of breast cancer to personalize the organized screening program

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