Depletion of CD8α+ lymphocytes attenuates CCL28 expression in villus epithelia in rats

Lee, Jae-Sung; Kamada, Saki; Takami, Yuri; Oka, Kohsuke; Ochiai, Y.; Iwaya, Hitoshi; Hara, Hiroshi; Ishizuka, Satoshi

doi:10.1016/j.imlet.2009.04.004

Cited by 1 publication

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“…Moreover, we demonstrated that CD8α + IELs contributes to expression of CCL28, a chemokine for IgA + B cells, in the villus epithelia (Lee et al, 2009b). In general, many researchers use splenocytes or mesenteric 11 lymphocytes to determine the influence of dietary components on immune cell functions.…”

Section: Discussionmentioning

confidence: 91%

Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents

et al. 2011

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We evaluated the effects of seven mushroom extracts (Grifola frondosa, Pholiota nameko, Panellus serotinus, Hypsizygus marmoreus, Pleurotus cornucopiae, Armillaria mellea, and Flammulina velutipes) on cytotoxic activity and cytokine production of lamina propria leukocytes (LPLs) isolated from rat small (S) and large (L) intestinal mucosa. Boiling water extracts from seven species of mushrooms showed no direct cytotoxicity against the YAC-1 target cells. However, prominent increases of cytotoxicity were observed in S-and L-LPLs co-cultured with P. serotinus extract. Cytokine production (TNFα, IFNγ, IL-12 p70, and IL-4) of S-and L-LPLs was stimulated in response to P. cornucopiae extract. Mushroom extracts contribute to target cell adhesion and/or cytokine production in the effector cells. The promotion of cytotoxic activity in S-and L-LPLs was not necessarily related to β-glucan content of the mushroom.

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Section: Discussionmentioning

confidence: 91%