Depletion of Essential Fatty Acids in Muscle Is Associated With Shorter Survival of Cancer Patients Undergoing Surgery

Bhullar, Amritpal S.; Rivas-Serna, Irma Magaly; Anoveros‐Barrera, Ana; Dunichand‐Hoedl, Abha R.; Bigam, David L.; Khadaroo, Rachel G.; McMullen, Todd; Bathe, Oliver F.; Putman, Charles T.; Baracos, Vickie E.; Clandinin, Michael T.; Mazurak, Vera C.

doi:10.21203/rs.3.rs-310922/v1

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“…Um dos fatores que podem levar à redução da SMD é a infiltração de gordura no músculo, chamada de miosteatose. Recentemente, foi relatado que o acúmulo de lipídios, tanto intramiocelular quanto ao redor do músculo (extramiocelular), define a baixa radiodensidade muscular reconhecida em pacientes críticos [96] e no câncer [113]. A resistência à insulina e a inflamação são as principais causas do acúmulo de lipídios na musculatura [114].…”

Section: Associação Das Medidas Do Tecido Muscular Esquelético Da Nlr...unclassified

Composição corporal e razão neutrófilo-linfócito como fatores de mal prognóstico para COVID-19

Morais de Hollanda Padilha

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Systemic inflammation and body composition changes are associated with a poor prognosis in many diseases, but their role in coronavirus disease 2019 is not fully understood. This study aimed to evaluate the impact of body composition assessed by computed tomography (CT), systemic inflammation assessed by neutrophil-to-lymphocyte ratio (NLR) and a composite score based on skeletal muscle density (SMD) and NLR on clinical outcomes of COVID-19, such as clinical complications, use of ventilatory support and survival. Medical records of patients hospitalized from May 1, 2020, to July 31, 2020, with a laboratory diagnosis of COVID-19 who underwent CT were retrospectively reviewed. The areas and densities of skeletal muscle tissue and adipose tissue were obtained by analyzing CT images assessed at the level of the first lumbar vertebra (L1); blood count was used to calculate the NLR. Prognostic values were estimated via univariate and multivariate logistic regression analyses and the Kaplan-Meier curve. The study was approved by our local Institutional Review Board (CAAE: 36276620.2.0000.5404). A total of 202 patients were included.The median age was 59 years, 45% of patients required ICU care and 45 (22.5%) patients died. Multivariate logistic analysis demonstrated that low SMD (OR: 2.94; 95% CI: 1.13-7.66, P=0.027), high NLR (OR: 3.96; 95% CI: 1.24-12.69, P=0.021), the association of low SMD and high NLR (OR: 25.58; 95%CI: 2.37-276.71, P=0.008) and high subcutaneous adipose tissue radiodensity (SATR) (OR: 2,70; IC 95%: 1,08-6,74, P=0,033) had an increased risk of dying. Patients who had high SATR and both low SMD and high NLR required more mechanical ventilation (P=0.007 and P<0.001, respectively) and were hospitalized for a longer period (both P< 0.001). We concluded that high SATR, low SMD, high NLR and the composite score (SMD and NLR) can predict poor prognosis in patients with COVID-19, and they may be used as a tool for early identification of patients at risk.

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Section: Associação Das Medidas Do Tecido Muscular Esquelético Da Nlr...unclassified

Composição corporal e razão neutrófilo-linfócito como fatores de mal prognóstico para COVID-19

Morais de Hollanda Padilha

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Depletion of Essential Fatty Acids in Muscle Is Associated With Shorter Survival of Cancer Patients Undergoing Surgery

Cited by 1 publication

References 38 publications

Composição corporal e razão neutrófilo-linfócito como fatores de mal prognóstico para COVID-19

Composição corporal e razão neutrófilo-linfócito como fatores de mal prognóstico para COVID-19

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