Depletion of
            <i>Blautia</i>
            Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

Benı́tez-Páez, Alfonso; Pugar, Eva M. Gómez del; López-Almela, Inmaculada; Moya-Pérez, Ángela; Codoñer‐Franch, Pilar; Sanz, Yolanda

doi:10.1128/msystems.00857-19

Cited by 243 publications

(175 citation statements)

References 50 publications

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“…Increasing evidence indicates that microorganisms residing in the gut have essential metabolic and immunological functions for the adaptation of their host species ( 10 ). It has been demonstrated previously that changes in relative abundances of some microbial taxa can change digestibility of the diet and the amount of energy harvested for the host species ( 11 – 13 ). Additionally, bacterial metabolites act as paracrine or endocrine factors and have a marked effect in regulating energy metabolism in host species ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations

et al. 2020

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Ambient temperature (Ta) is an important factor in shaping phenotypic plasticity. Plasticity is generally beneficial for animals in adapting to their environments. Gut microbiota are crucial in regulating host physiological and behavioral processes. However, whether the gut microbiota play a role in regulating host phenotypic plasticity under the conditions of repeated fluctuations in environmental factors has rarely been examined. We used intermittent Ta acclimations to test the hypothesis that the plasticity of gut microbiota confers on the host a metabolic adaptation to Ta fluctuations. Mongolian gerbils (Meriones unguiculatus) were acclimated to intermittent 5°C to 23°C, 37°C to 23°C or 23°C to 23°C conditions for 3 cycles (totally 3 months). Intermittent Ta acclimations induced variations in resting metabolic rate (RMR), serum thyroid hormones, and core body temperature (Tb). We further identified that the β-diversity of the microbial community varied with Ta and showed diverse responses during the 3 cycles. Some specific bacteria were more sensitive to Ta and were associated with host dynamic metabolic plasticity during Ta acclimations. In addition, depletion of gut microbiota in antibiotic-treated gerbils impaired metabolic plasticity, particularly at low Ta, whereas supplementation with propionate as an energy resource improved the inhibited thermogenic capacity and increased the survival rate in the cold. These findings demonstrate that both gut microbiota and their host were more adaptive after repeated acclimations, and dynamic gut microbiota and their metabolites may confer host plasticity in thermoregulation in response to Ta fluctuations. It also implies that low Ta is a crucial cue in driving symbiosis between mammals and their gut microbiota during evolution. IMPORTANCE Whether gut microbiota play a role in regulating host phenotypic plasticity in small mammals living in seasonal environments has rarely been examined. The present study, through an intermittent temperature acclimation model, indicates that both gut microbiota and their host were more adaptive after repeated acclimations. It also demonstrates that dynamic gut microbiota confer host plasticity in thermoregulation in response to intermittent temperature fluctuations. Furthermore, low temperature seems to be a crucial cue in driving the symbiosis between mammals and their gut microbiota during evolution.

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Section: Introductionmentioning

confidence: 99%

Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations

et al. 2020

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“…Therefore, the deletion of these taxa may be involved as a common mechanism for primary and metachronous GC after the eradication of H. pylori. Anti-inflammatory effects have been demonstrated for Blautia and Faecalibacterium in gastrointestinal diseases, including inflammatory bowel diseases and intestinal graft-versus-host disease [33][34][35][36]. Interestingly, colorectal cancer tissues show a reduction in the abundance of these taxa [37,38].…”

Section: Discussionmentioning

confidence: 99%

Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer

et al. 2020

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Background Gastric microbiome, other than Helicobacter pylori, plays a role in the tumorigenesis of gastric cancer (GC). Patients who undergo endoscopic submucosal dissection for early GC have a high risk of developing metachronous GC even after successful eradication of H. pylori. Thus, we investigated the microbial profiles and associated changes in such patients after the eradication of H. pylori. Methods A total of 19 H. pylori-infected patients with early GC who were or to be treated by endoscopic resection, with paired biopsy samples at pre- and post-eradication therapy, were retrospectively enrolled. Ten H. pylori-negative patients were enrolled as controls. Biopsy samples were analyzed using 16S rRNA sequencing. Results H. pylori-positive patients exhibited low richness and evenness of bacteria with the deletion of several genera, including Blautia, Ralstonia, Faecalibacterium, Methylobacterium, and Megamonas. H. pylori eradication partially restored microbial diversity, as assessed during a median follow-up at 13 months after eradication therapy. However, post-eradication patients had less diversity than that in the controls and possessed a lower abundance of the five genera mentioned above. The eradication of H. pylori also altered the bacterial composition, but not to the same extent as that in controls. The microbial communities could be clustered into three separate groups: H. pylori-negative, pre-eradication, and post-eradication. Conclusion Changes in dysbiosis may persist long after the eradication of H. pylori in patients with a history of GC. Dysbiosis may be involved in the development of both primary and metachronous GC after the eradication of H. pylori in such patients.

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“…However, a significant decrease in the relative abundance of Firmicutes was observed in SBM group compared with FM group, which was mainly attributed to losses of Blautia, while no such a difference was found between C1 and FM group, suggesting the relative abundance of Blautia was profitably increased by dietary CAD. Blautia is well-recognized as part of the butyrate-producing bacteria genus of the intestinal microbiota (Biddle et al, 2013;De Filippis et al, 2016), and some of Blautia species were able to reduce the ratio of pro-to anti-inflammatory cytokines ratio in human mononuclear cells (Benítez-Páez et al, 2020). Therefore, it is possible that the thriving of Blautia by diet C1 might facilitate the inflammation regulation.…”

Section: Discussionmentioning

confidence: 99%

The Antimicrobial Peptide Cecropin AD Supplement Alleviated Soybean Meal-Induced Intestinal Inflammation, Barrier Damage, and Microbial Dysbiosis in Juvenile Turbot, Scophthalmus maximus

Dai

et al. 2020

Front. Mar. Sci.

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This study aimed to investigate the benefit of dietary cecropin AD (CAD) on the intestinal health of turbot (Scophthalmus maximus) fed diets with a high level of soybean meal. A 12-week feeding trial was conducted with four isonitrogenous and isolipidic diets: a fishmeal-based diet (FM), a diet replacing 40% fish meal protein of FM diet with soybean meal protein (SBM), and the SBM diet supplemented with 0.5 g/kg (C1) and 1.0 g/kg (C2) CAD, respectively. The results of histology of distal intestine (DI) showed that turbots fed the SBM diet exhibited distinct symptoms of enteritis. However, fish fed diets with CAD supplementation kept the normal appearance of the DI which was similar to that in FM group. Compared with the SBM group, diet with CAD supplementation significantly decreased the gene expression of intestinal pro-inflammatory cytokines tumor necrosis factor-α (tnf-α), interleukin-1β (il-1β), interferon-gamma (ifn-γ), and nuclear factor-kappa B p65 (nf-κb p65), while up-regulated the gene expression of intestinal tight junction proteins claudin-3, claudin-4, occludin, and zonula occludens-1 (zo-1). Besides, diet C1 shaped the intestinal microbiota profile toward an anti-inflammatory phenotype represented by the increased abundance of Blutia, Firmicutes/Bacteroides ratio, and decreased Prevotellaceae. In conclusion, dietary CAD could positively modulate the intestinal health of turbot from the impairment induced by soybean meal, which expands its application to help fish better adapt to the increasing plant protein level in aquafeed.

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Depletion of Blautia Species in the Microbiota of Obese Children Relates to Intestinal Inflammation and Metabolic Phenotype Worsening

Cited by 243 publications

References 50 publications

Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations

Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations

Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer

The Antimicrobial Peptide Cecropin AD Supplement Alleviated Soybean Meal-Induced Intestinal Inflammation, Barrier Damage, and Microbial Dysbiosis in Juvenile Turbot, Scophthalmus maximus

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