Depolarization of light in biological tissues

Fixler, Dror; Ankri, Rinat; Duadi, Hamootal; Lubart, Rachel; Zalevsky, Zeev

doi:10.1016/j.optlaseng.2012.01.011

Cited by 12 publications

(4 citation statements)

References 31 publications

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“…As to LED, there are accumulating data showing that there is no difference in the interaction of a laser and a LED with the human tissue [36][37][38][39][40]. These studies showed positive effects in prevention and treatment of oral mucositis but represent initial investigations of new light technologies, and with the available information no guideline was possible.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Migliorati

Hewson

Lalla

et al. 2012

Support Care Cancer

215

105

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Background The aim of this study was to review the available literature and define clinical practice guidelines for the use of laser and other light therapies for the prevention and treatment of oral mucositis. the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. Results A new recommendation was made for low-level laser (wavelength at 650 nm, power of 40 mW, and each square centimeter treated with the required time to a tissue energy dose of 2 J/cm 2 (2 s/point)) for the prevention of oral mucositis in adult patients receiving hematopoietic stem cell transplantation conditioned with high-dose chemotherapy, with or without total body irradiation. A new suggestion was made for low-level laser (wavelength around 632.8 nm) for the prevention of oral mucositis in patients undergoing radiotherapy, without concomitant chemotherapy, for head and neck cancer. No guideline was possible in other populations and for other light sources due to insufficient evidence. Conclusions The increasing evidence in favor of low-level laser therapy allowed for the development of two new guidelines supporting this modality in the populations listed above. Evidence for other populations was also generally encouraging over a range of wavelengths and intensities. However, additional well-designed research is needed to evaluate the efficacy of laser and other light therapies in various cancer treatment settings. Methods

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Section: Resultsmentioning

confidence: 99%

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Migliorati

Hewson

Lalla

et al. 2012

Support Care Cancer

215

105

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“…The results demonstrated that polarization was largely unaffected when passing through static tissue or, when the fluid flow was parallel to the polarization direction. Polarization was partially lost when flow was perpendicular to the polarization direction and when the rate of fluid movement was increased [85]. Considering all this, in conjunction with the known effects of PPBMT in animal models [31,70] it seems plausible that polarized light aligned parallel to cylindrical, or linear biological microstructures such as myofibrils, axons or collagen fibres [79] may represent a more efficacious method to administer PBMT.…”

Section: Limitationsmentioning

confidence: 99%

Good, better, best? The effects of polarization on photobiomodulation therapy

Tripodi

Feehan

Husaric

et al. 2020

Journal of Biophotonics

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Photobiomodulation therapy (PBMT) is a widely adopted form of phototherapy used to treat many chronic conditions that effect the population at large. The exact physiological mechanisms of PBMT remain unsolved; however, the prevailing theory centres on changes in mitochondrial function. There are many irradiation parameters to consider when investigating PBMT, one of which is the state of polarization. There is some evidence to show that polarization of red and nearinfrared light may promote different and/or increased biological activity when compared to otherwise identical non-polarized light. These enhanced cellular effects may also be present when the polarized light is applied linear to the tissue direction. Herein, we synthesize the current experimental and clinical evidence pertaining to polarized photobiomodulation therapy; ultimately, to better inform future research into this area of phototherapy.

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“…An important difference of this approach is that laser radiation can be delivered to specific internal organ or tissue in vivo, without any loss of its coherence and polarization. 30,31 This fact is very significant for the imaging and shaping of beams for more efficient illumination. We will do this with an implantable pill.…”

Section: Implantable Pillmentioning

confidence: 99%

Implantable photonic devices for improved medical treatments

Sheinman

Rudnitsky

Toichuev³

et al. 2014

J. Biomed. Opt

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An evolving area of biomedical research is related to the creation of implantable units that provide various possibilities for imaging, measurement, and the monitoring of a wide range of diseases and intrabody phototherapy. The units can be autonomic or built-in in some kind of clinically applicable implants. Because of specific working conditions in the live body, such implants must have a number of features requiring further development. This topic can cause wide interest among developers of optical, mechanical, and electronic solutions in biomedicine. We introduce preliminary clinical trials obtained with an implantable pill and devices that we have developed. The pill and devices are capable of applying in-body phototherapy, low-level laser therapy, blue light (450 nm) for sterilization, and controlled injection of chemicals. The pill is also capable of communicating with an external control box, including the transmission of images from inside the patient’s body. In this work, our pill was utilized for illumination of the sinus-carotid zone in dog and red light influence on arterial pressure and heart rate was demonstrated. Intrabody liver tissue laser ablation and nanoparticle-assisted laser ablation was investigated. Sterilization effect of intrabody blue light illumination was applied during a maxillofacial phlegmon treatment.

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Depolarization of light in biological tissues

Cited by 12 publications

References 31 publications

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Systematic review of laser and other light therapy for the management of oral mucositis in cancer patients

Good, better, best? The effects of polarization on photobiomodulation therapy

Implantable photonic devices for improved medical treatments

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