Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA

Zhao, Jinping; Gillam, M.; Taylor, Carla G.; Weiler, Hope A.

doi:10.1016/j.jnutbio.2010.06.012

Cited by 8 publications

(5 citation statements)

References 64 publications

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“…Besides, it has been argued that there is greater evidence for DHA playing a preventive rather than curative role in dementia ( 27 ) . This role may be more important in unhealthy populations, for instance, in patients with type 2 diabetes ( 91 ) . Namely, it is not clear if an adequate brain DHA level can be kept in obesity and insulin-resistant states.…”

Section: Dha and The Cognitive Functionmentioning

confidence: 99%

Dietary DHA and health: cognitive function ageing

2016

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DHA is a key nutritional n-3 PUFA and needs to be supplied by the human diet. DHA is found in significant amounts in the retinal and neuronal cell membranes due to its high fluidity. Indeed, DHA is selectively concentrated in the synaptic and retinal membranes. DHA is deemed to display anti-inflammatory properties and to reduce the risk of CVD. Consumption of larger amounts of DHA appears to reduce the risk of depression, bipolar disorder, schizophrenia and mood disorders. Conversely, it has been shown that loss of DHA from the nerve cell membrane leads to dysfunction of the central nervous system in the form of anxiety, irritability, susceptibility to stress, dyslexia, impaired memory and cognitive functions, and extended reaction times. DHA plays an important role in ensuring a healthy ageing, by thwarting macular degeneration, Alzheimer's disease, and other brain disorders at the same time as enhancing memory and strengthening neuroprotection in general. A reduced level of DHA is associated with cognitive decline during ageing. Different mechanisms for this fundamental DHA role have been put forward. Namely, neuroprotectin D1, a DHA derivative, may support brain cell survival and repair through neurotrophic, anti-apoptotic, and anti-inflammatory signalling. Many of the effects of DHA on the neurological system may be related to signalling connections, thus leading to the study of the related signalolipidomics. Therefore, the present review will focus on the influence of DHA deficiency upon ageing, with specific emphasis upon neurological disorders related to cognitive function and mental health.

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Section: Dha and The Cognitive Functionmentioning

confidence: 99%

Dietary DHA and health: cognitive function ageing

2016

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“…The fatty acid composition of membrane phospholipids is likely to be affected by the exogenous fatty acids from the diet or by altered activities of lipid-metabolizing enzymes such as fatty acid desaturases [ 1 , 2 ]. Also, some vitamins and trace elements that occur in the human diet are known to participate in phospholipid homeostasis in different cells.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Deficiencies and Phospholipid Metabolism

Giménez

Oliveros

Gómez

2011

IJMS

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Phospholipids are important components of the cell membranes of all living species. They contribute to the physicochemical properties of the membrane and thus influence the conformation and function of membrane-bound proteins, such as receptors, ion channels, and transporters and also influence cell function by serving as precursors for prostaglandins and other signaling molecules and modulating gene expression through the transcription activation. The components of the diet are determinant for cell functionality. In this review, the effects of macro and micronutrients deficiency on the quality, quantity and metabolism of different phospholipids and their distribution in cells of different organs is presented. Alterations in the amount of both saturated and polyunsaturated fatty acids, vitamins A, E and folate, and other micronutrients, such as zinc and magnesium, are discussed. In all cases we observe alterations in the pattern of phospholipids, the more affected ones being phosphatidylcholine, phosphatidylethanolamine and sphingomyelin. The deficiency of certain nutrients, such as essential fatty acids, fat-soluble vitamins and some metals may contribute to a variety of diseases that can be irreversible even after replacement with normal amount of the nutrients. Usually, the sequelae are more important when the deficiency is present at an early age.

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“…Moreover, phospholipids' structural abnormali-ties directly change the cell membrane structure and cause abnormal cell function. Lipids have been found to affect the cell membrane phospholipid fatty acid composition (Field et al, 1990;Le Guennec et al, 2010;Zhao et al, 2011). Furthermore, ITFA bind to membrane phospholipids, which triggers cellular inflammatory responses and causes abnormal cell and blood vessel function (Harvey et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Phospholipids are one of the important components of organisms and are closely related to CVD (Hinterwirth et al, 2014). The fatty acid composition of membrane phospholipids is likely to be affected by exogenous fatty acids from the diet (Le Guennec et al, 2010;Zhao et al, 2011). Feeding a diet with a high ratio of polyunsaturated to saturated fatty acids has been found to significantly increase the content of PUFA in plasma membrane phospholipids of fat cells in diabetic and nondiabetic animals (Field et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Trans triacylglycerols from dairy products and industrial hydrogenated oil exhibit different effects on the function of human umbilical vein endothelial cells via modulating phospholipase A2/arachidonic acid metabolism pathways

Wei

Zhou

Luo

et al. 2021

Journal of Dairy Science

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Dairy fat intake has been considered as a risk factor for cardiovascular disease. Rodent models show that trans fatty acids in industrial hydrogenated oil and ruminant milk have different effects on cardiovascular diseases. One of the main reasons is that the distributions of trans fatty acids in triacylglycerols from dairy products and from industrial hydrogenated oil are different, which affects lipid absorption and metabolism. This study investigated the effects of 1,3-olein-2-elaidin (OEO, representing industrial hydrogenated oil triacylglycerols) and 1-vaccenic-2,3-olein (OOV, representing ruminant triacylglycerols in dairy products) on the function of human umbilical vein endothelial cells (HUVEC), including cell viability, lactate dehydrogenase (LDH) exudation rate, and nitric oxide secretory and nitric oxide synthase relative activity. We found that the detrimental effect of OEO on HUVEC was significantly greater than that of OOV. The results also showed that the absorption rate of OEO in HUVEC (78.25%) was significantly greater than that of OOV (63.32%). Mechanistically, based on phospholipidomics analysis, we found that calcium-independent phospholipase A2 (iPLA2) played a key role with regard to the OOV-mediated arachidonic acid (ARA)/COX-2/PG pathway, whereas secretory phospholipase A2 (sPLA2) and cytoplasmic phospholipase A2 (cPLA2) are responsible for the OEO-mediated ARA/COX-2/PG pathway. Moreover, OEO had a greater effect on the protein expression of COX-2 and PG secretion than OOV. In addition, iPLA2, sPLA2, and cPLA2 could mediate the ARA/CYP4A11 pathway in OOV-treated HUVEC, but only iPLA2 could mediate this pathway in HUVEC treated with OEO. We also found that sPLA2 could mediate the ARA/5-LOX pathway in HUVEC treated with OOV, but none of these 3 forms of PLA2 could mediate this pathway in HUVEC treated with OEO. On the other hand, after OOV treatment, trans-11 C18:1 was converted to beneficial forms of fatty acids in HUVEC, including conjugated linoleic acid (CLA) and trans-9 C16:1. In conclusion, we elucidated the potential mechanisms that might account for the diverse effects of triacylglycerols from industrial hydrogenated oil and ruminant milk on the function of HUVEC.

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Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA

Cited by 8 publications

References 64 publications

Dietary DHA and health: cognitive function ageing

Dietary DHA and health: cognitive function ageing

Nutritional Deficiencies and Phospholipid Metabolism

Trans triacylglycerols from dairy products and industrial hydrogenated oil exhibit different effects on the function of human umbilical vein endothelial cells via modulating phospholipase A2/arachidonic acid metabolism pathways

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