Cochrane Database of Systematic Reviews 2015
DOI: 10.1002/14651858.cd011969
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Deprescribing versus continuation of chronic proton pump inhibitor use in adults

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Cited by 34 publications
(42 citation statements)
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“…Jiang et al [ 29 ] concluded that on-demand treatment with PPIs is superior to continuous or placebo therapy, but did not perform subgroup analysis of NERD and mild EE. A recently published Cochrane review showed that on-demand deprescribing may lead to an increase in gastrointestinal symptoms (e.g., dyspepsia and regurgitation) in patients with NERD or mild grades of EE (Los Angeles grades A and B or Savary-Miller grades 1 and 2) [ 30 ]. Besides having a broad definition for on-demand deprescribing, this review did not differentiate NERD from mild EE; Savary-Miller grading for most of the included patients was >1.…”
Section: Discussionmentioning
confidence: 99%
“…Jiang et al [ 29 ] concluded that on-demand treatment with PPIs is superior to continuous or placebo therapy, but did not perform subgroup analysis of NERD and mild EE. A recently published Cochrane review showed that on-demand deprescribing may lead to an increase in gastrointestinal symptoms (e.g., dyspepsia and regurgitation) in patients with NERD or mild grades of EE (Los Angeles grades A and B or Savary-Miller grades 1 and 2) [ 30 ]. Besides having a broad definition for on-demand deprescribing, this review did not differentiate NERD from mild EE; Savary-Miller grading for most of the included patients was >1.…”
Section: Discussionmentioning
confidence: 99%
“…9,10 Promisingly, six randomized PPI deintensification trials in a metaanalysis found that deprescribing can reduce PPI use and pill burden. 11 Other well-designed quality improvement (QI) studies attempting to reduce potentially low-value PPI prescriptions have found mixed results 12,13 and importantly none of the six randomized trials were conducted among older Americans.…”
mentioning
confidence: 99%
“…Our results indicate the importance of even a small benefit gained in pain control by continuing PPI treatment in order to rationalise its prolonged use. As FD is the most controversial medical situation treated with PPIs,13 25–27 we can extrapolate from our results to other gastrointestinal diseases that require prolonged PPI treatment such as GORD28–31 or peptic disease 32…”
Section: Discussionmentioning
confidence: 94%