Depression and Cognitive Impairment in Peritoneal Dialysis: A Multicenter Cross-sectional Study

Dong, Jie; Pi, Hai-Chen; Xiong, Zuying; Liao, Jinlan; Hao, Li; Liu, Guiling; Ren, Ye-Ping; Wang, Qin; Duan, Liping; Zheng, Zhaoxia

doi:10.1053/j.ajkd.2015.06.025

Cited by 45 publications

(58 citation statements)

References 60 publications

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“…[15][16][17] Using different depression screening measures, depression prevalence ranging from 14.8% to 52% has also been reported among PD patients. 13,18 Eventually, the prevalence of depression in PD patients obtained in the present study is within the suggested range in previous studies. The frequency of anxiety in PD patients was 50% in the present study.…”

Section: Discussionsupporting

confidence: 89%

Serum apelin is associated with affective disorders in peritoneal dialysis patients

et al. 2016

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Objective: Depression and anxiety are prevalent affective disorders in peritoneal dialysis (PD) patients. Recent research has proposed a potential role of apelinergic system in pathogenesis of depression. The present study aimed to evaluate the frequency of depression and anxiety and their potential relation with serum apelin levels among PD patients. Methods: A total of 40 PD patients were enrolled into the study. Depressive symptoms and anxiety were assessed with the Beck's Depression Inventory and the Beck's Anxiety Inventory. Serum apelin-12 levels were measured by immunoenzymatic assays using commercially available ELISA kit for standard human apelin. Results: Of the patients, 16 (40%) had depression, 20 (50%) had anxiety. The patients with depression and anxiety had a significantly longer time on dialysis (p < 0.001 for both), significantly higher serum apelin (p < 0.001 for both) and C-reactive protein levels (p < 0.001 for both) than those without depression and anxiety. In multivariate analysis, serum apelin was the only parameter associated independently with depression and anxiety scores. Conclusions: A substantial number of PD patients had depression and anxiety. Increased levels of serum apelin may constitute a significant independent predictor of development of depression and anxiety in PD patients. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 89%

Serum apelin is associated with affective disorders in peritoneal dialysis patients

et al. 2016

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“…37,38 However, our rate of cognitive impairment was higher than reported by other studies. 6,39 Cognitive impairment in our patients was strongly associated with older age (data not shown). Similarly, aging in dialysis patients and the presence of cerebrovascular diseases were shown to play a major role in the pathophysiology of cognitive impairment.…”

Section: Resultsmentioning

confidence: 52%

“…[5][6][7] The prevalence of depression and anxiety has been discussed in several studies, with a wide range of variabilities probably due to the populations examined, methods of diagnosis, and dialysis modality. 7,8 Depression has been specifically linked to a poor quality of life and increased risk of mortality.…”

Section: Introductionmentioning

confidence: 99%

<div>Psychosocial predictors of nonadherence to medical management among patients on maintenance dialysis</div>

Alosaimi¹,

Asiri²,

Alsuwayt³

et al. 2016

IJNRD

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“…This is an add-on study to the previous multi-center cross-sectional survey of cognitive function in PD patients conducted between March 2013 and March 2014 [20]. Among the 222 patients enrolled from Peking University First Hospital in that survey, 60 PD patients who satisfied the inclusion and exclusion criteria of this study and were willing to participate in the neuroimaging examination were recruited.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…Patients without history of stroke or contraindications for MRI were invited to undergo a 3-dimensional MRI (3D-MRI) scan as introduced by a previous literature [20]. MRI was performed with a 3.0-T MR imaging unit (Signa Excite; GE Medical Systems, Milawaukee, WI, USA) using an eight-channel head coil.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease

et al. 2016

Kidney Blood Press Res

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Background/Aims: Cognitive impairment and abnormal structural neuroimaging is common in chronic kidney disease patients. We aimed to explore its association with dialysis modality and the relationship between cognitive impairment and abnormal structural neuroimaging. Methods: Sixty peritoneal dialysis patients and 30 hemodialysis and 30 non-dialyzed stage 3-5 chronic kidney disease patients without history of stroke were enrolled for the study. Participants were matched for age, gender, education, diabetes status, and dialysis duration (if appropriate). Cognitive functions were measured using a battery of recognized instruments. Brain features were examined with 3-dimensional magnetic resonance imaging. Results: Cognitive impairment was significantly more severe in dialysis patients than in non-dialyzed patients. The global and specific cognitive function were not significantly different between patients on peritoneal dialysis and hemodialysis. Hemodialysis patients had more severe white matter hyperintensity, sulcal and ventricular atrophy, and SVIs than other patients. In all groups, higher white matter grade, ventricular grade, and hippocampal atrophy were significantly associated with global cognitive impairment, with hazard ratios of 1.80 (1.22-2.64), 1.67 (1.09-2.57), and 2.49 (1.07-5.77), respectively. White matter grade was also significantly associated with delayed memory (hazard ratio 1.63; 1.12-2.39). Conclusion: Dialysis modality showed no association with cognitive impairment, although hemodialysis patients had more severe neuroimaging abnormalities. For the whole group, white matter hyperintensity, and ventricular and hippocampal atrophy, were independently associated with global cognitive impairment in chronic kidney disease patients.

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Depression and Cognitive Impairment in Peritoneal Dialysis: A Multicenter Cross-sectional Study

Cited by 45 publications

References 60 publications

Serum apelin is associated with affective disorders in peritoneal dialysis patients

Serum apelin is associated with affective disorders in peritoneal dialysis patients

<div>Psychosocial predictors of nonadherence to medical management among patients on maintenance dialysis</div>

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease

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