Depression and Microbiome—Study on the Relation and Contiguity between Dogs and Humans

Abstract

Behavioral studies demonstrate that not only humans, but all other animals including dogs, can suffer from depression. A quantitative molecular evaluation of fatty acids in human and animal platelets has already evidenced similarities between people suffering from depression and German Shepherds, suggesting that domestication has led dogs to be similar to humans. In order to verify whether humans and dogs suffering from similar pathologies also share similar microorganisms at the intestinal level, in this study the gut-microbiota composition of 12 German Shepherds was compared to that of 15 dogs belonging to mixed breeds which do not suffer from depression. Moreover, the relation between the microbiota of the German Shepherd’s group and that of patients with depression has been investigated. The results indicate that the German Shepherd’s gut-microbiota has a different composition compared to other dog breeds and is characterized by microbial groups identified in humans with depression, highlighting the existence of a “core” microbiota associated with depression.

Probiotics and Microbiota-Derived Molecules for Inflammation, Neuroinflammation and Mood Disorders

“…In their article, Mondo et al [4] report the results of a study analyzing the gut microbiota of the German Shepherd dog breed and humans. They found that the German Shepherd's gut microbiota has a different composition than other dog breeds and, in particular, shows a significant resemblance to that of depressed humans.…”