Depression and Risk for Diabetes: A Meta-Analysis

Yu, Min; Zhang, Xingliang; Lu, Feng; Fang, Le

doi:10.1016/j.jcjd.2014.11.006

Cited by 200 publications

(141 citation statements)

References 63 publications

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“…Depressive symptoms increase during adolescence, primarily in girls (Hankin et al, 1998), as does puberty-related insulin resistance, which influences future progression to T2D (Goran, Shaibi, Weigensberg, Davis, & Cruz, 2006). Consistent with adult data (Yu, Zhang, Lu, & Fang, 2015), adolescent depressive symptoms correlate with poorer insulin sensitivity, independent of body composition, and predict worsening insulin sensitivity and T2D onset over time, irrespective of body mass index (BMI, kg/m 2 ) or BMI gain (Shomaker & Goodman, 2015; Shomaker et al, 2011; Shomaker et al, 2010; Suglia, Demmer, Wahi, Keyes, & Koenen, 2016). …”

supporting

confidence: 71%

Prevention of insulin resistance in adolescents at risk for type 2 diabetes with depressive symptoms: 1-year follow-up of a randomized trial

et al. 2017

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Background Depression is associated with poor insulin sensitivity. We evaluated long-term effects of a cognitive-behavioral therapy (CBT) program for prevention of depression on insulin sensitivity in adolescents at risk for type 2 diabetes (T2D) with depressive symptoms. Methods One-hundred nineteen adolescent females with overweight/obesity, T2D family history, and mild-to-moderate depressive symptoms were randomized to a six-week CBT group (n=61) or six-week health education (HE) control group (n=58). At baseline, post-treatment, and one year, depressive symptoms were assessed, and whole body insulin sensitivity (WBISI) was estimated from oral glucose tolerance tests. Dual energy x-ray absorptiometry assessed fat mass at baseline and one year. Primary outcomes were one-year changes in depression and insulin sensitivity, adjusting for adiposity and other relevant covariates. Secondary outcomes were fasting and two-hour insulin and glucose. We also evaluated the moderating effects of baseline depressive symptom severity. Results Depressive symptoms decreased in both groups (P<0.001). Insulin sensitivity was stable in CBT and HE (ΔWBISI 0.1 vs. 0.3) and did not differ between groups (P=0.63). However, among girls with greater (moderate) baseline depressive symptoms (N=78), those in CBT developed lower 2-hour insulin than those in HE (Δ-16 vs. 16μIU/mL, P<.05). Additional metabolic benefits of CBT were seen for this subgroup in post-hoc analyses of post-treatment to one-year change. Conclusions Adolescent females at risk for T2D decreased depressive symptoms and stabilized insulin sensitivity one year following brief CBT or HE. Further studies are required to determine if adolescents with moderate depression show metabolic benefits after CBT.

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supporting

confidence: 71%

Prevention of insulin resistance in adolescents at risk for type 2 diabetes with depressive symptoms: 1-year follow-up of a randomized trial

et al. 2017

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“…This may not always be the case. For example, the association between depression and diabetes is complex; some studies have found depression is associated with incident type 2 diabetes [12, 13], while others have found that type 2 diabetes precedes depression [12, 53]. If the latter is true, it would be inappropriate to consider depression as a mediating variable.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, CM has been shown to predict unhealthy behaviors in adolescence and adulthood such as smoking [6–9] and physical inactivity [7, 8], which are also risk factors for type 2 diabetes [3, 10, 11]. Finally, there is evidence that depression [12, 13] and hypertension [14, 15] are predictive of type 2 diabetes. Both have been shown to be outcomes of CM [1, 2, 16–18] and as such, may be in the causal pathway between CM and diabetes.…”

Section: Introductionmentioning

confidence: 99%

Childhood maltreatment as a risk factor for diabetes: findings from a population-based survey of Canadian adults

et al. 2016

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BackgroundIt is well established that childhood maltreatment (CM) is a risk factor for various mental and substance use disorders. To date, however, little research has focused on the possible long-term physical consequences of CM. Diabetes is a chronic disease, for which an association with CM has been postulated.MethodsBased on data from a sample of 21,878 men and women from the 2012 Canadian Community Health Survey - Mental Health (CCHS - MH), this study examines associations between three types of CM (childhood physical abuse (CPA), childhood sexual abuse (CSA), and childhood exposure to intimate partner violence (CEIPV)) and diabetes in adulthood. Multiple logistic regression models were used to examine associations between CM and diabetes controlling for the effects of socio-demographic characteristics and risk factors for type 2 diabetes.ResultsWhen controlling socio-demographic characteristics, diabetes was significantly associated with reports of severe and frequent CPA (OR = 1.8) and severe and frequent CSA (OR = 2.2). A dose–response relationship was observed when co-occurrence of CSA and CPA was considered with the strongest association with diabetes being observed when both severe and frequent CSA and CPA were reported (OR = 2.6). Controlling for type 2 diabetes risk factors attenuated associations particularly for CPA. CEIPV was not significantly associated with having diabetes in adulthood.ConclusionCPA and CSA are risk factors for diabetes. For the most part, associations between CPA and diabetes are mediated via risk factors for type 2 diabetes. Failure to consider severity and frequency of abuse may limit our understanding of the importance of CM as a risk factor for diabetes.

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“…T1D may contribute to emotional and biological disruptions, so that depression exacerbates dyslipidaemia 46 . It is also assumed that depression itself is a moderate risk factor for developing DM in young adults, either directly or indirectly [47][48][49] . Irving and colleagues 47 explained other biological mechanisms.…”

Section: Biological Mechanismsmentioning

confidence: 99%

Anxiety and depressive disorders in children and adolescents suffering from diabetes mellitus

2018

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Abstract. Diabetes mellitus (DM) and mental health problems are frequently co-occurring conditions. Anxiety and depressive disorders are the most common mental disorders that accompany DM. These conditions could have severe consequences in children and adolescents suffering from DM. Thus, it is important to pay additional attention to them. This article provides an overview of prevalence rates of DM and co-occurring anxiety and depression, as well as understanding the etiology and treatment options for anxiety and depressive disorders in children and adolescents with DM. Key words: anxiety disorders; depression; diabetes mellitusSažetak. Diabetes mellitus (DM) i psihički poremećaji često su u komorbiditetu. Anksiozni i depresivni poremećaji najčešći su duševni poremećaji koji prate DM. Ovi mentalni poremećaji mogu imati ozbiljne posljedice za djecu i adolescente koji boluju od DM-a, stoga je važno posvetiti im dodatnu pozornost. U radu donosimo kratak pregled prevalencije DM-a i komorbiditetnih anksioznih i depresivnih poremećaja te razumijevanje etioloških karakteristika. Ukratko smo se osvrnuli i na mogućnosti liječenja djece i adolescenata koji imaju DM i anksiozni odnosno depresivni poremećaj. Ključne riječi: anksiozni poremećaji; depresivni poremećaji; diabetes mellitusMini-review/Kratki pregledni članak 1 Odsjek za psihologiju, Filozofski fakultet, Sveučilište u Rijeci, Rijeka 2 Klinika za neurologiju i psihijatriju za decu i omladinu, Beograd, Srbija 3 Katedra za psihijatriju i psihološku medicinu, Medicinski fakultet, Sveučilište u Rijeci, Rijeka

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Depression and Risk for Diabetes: A Meta-Analysis

Cited by 200 publications

References 63 publications

Prevention of insulin resistance in adolescents at risk for type 2 diabetes with depressive symptoms: 1-year follow-up of a randomized trial

Prevention of insulin resistance in adolescents at risk for type 2 diabetes with depressive symptoms: 1-year follow-up of a randomized trial

Childhood maltreatment as a risk factor for diabetes: findings from a population-based survey of Canadian adults

Anxiety and depressive disorders in children and adolescents suffering from diabetes mellitus

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