Depression and the willingness to expend cognitive and physical effort for rewards: A systematic review

Horne, Sarah; Topp, Tzippora E.; Quigley, Leanne

doi:10.1016/j.cpr.2021.102065

Cited by 38 publications

(27 citation statements)

References 56 publications

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Section: Introductionmentioning

confidence: 99%

“…We focused on neural activity changes in the choice phase between the SD and HC groups as it represents a cost-benefit trade-off between effort costs and potential rewards (Klein-Flügge et al, 2016;Scholl et al, 2015). As depressive individuals have shown impaired motivational effort decision-making and self-relevant processing relative to the healthy population (Hobbs et al, 2021;Horne et al, 2021), we hypothesize that SD would show less effortful motivation under the "effort for self" condition. Based on the blunt activity in the dACC/DMPFC, insula, and dorsal striatum in individuals with depression (Pizzagalli et al, 2009;Rzepa & McCabe, 2019;Smoski et al, 2009), as well as the critical functions of these regions in effort-based decision-making (Klein-Flügge et al, 2016;Kurniawan et al, 2013), we further expect that the activation and functional connectivity pattern of these brain areas would be altered during effortful decisions for self in SD.…”

Section: Introductionmentioning

confidence: 99%

“…Motivational deficit accompanied by limited anticipatory pleasure is a typical feature of depression (Sherdell et al, 2012; Treadway & Zalda, 2011; Ubl et al, 2015; D. Zhang et al, 2020), which results in patients' impairments in social and life functioning (Horne et al, 2021; National Institute of Mental Health, 2019; Pietrzak et al, 2012). Motivation is goal‐directed and the term effort , which refers to the intensification of physical or mental activities needed to obtain desired outcomes (Grahek et al, 2019; Inzlicht et al, 2018), is a central concept in motivation studies (Braver et al, 2014; Grahek et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Altered motivation of effortful decision‐making for self and others in subthreshold depression

Rong

Dong

Zheng

et al. 2022

Depression and Anxiety

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Background: Amotivation is a typical feature in major depressive disorders and refers to individuals exhibiting reduced willingness to exert effort for rewards.However, the motivation pattern when deciding whether to exert effort for self versus others in people with depression remains unclear.Methods: We conducted a functional magnetic resonance imaging study and employed an adapted Effort-Expenditure for Rewards Task in subthreshold depressive (SD) participants (n = 33) and healthy controls (HC) (n = 32). This required participants to choose between a fixed low-effort/low-reward and a variable higheffort/high-reward option, and then immediately exert effort to obtain corresponding rewards for themselves or for unfamiliar people.Results: Compared with the HC group, the SD group showed blunted activity in the left dorsal anterior cingulate cortex/dorsomedial prefrontal cortex, bilateral anterior insula (AI), and right putamen-left dorsolateral prefrontal cortex functional connectivity when choosing to exert effort for themselves. Additionally, the SD group exhibited increased willingness and greater activation in the bilateral AI when choosing to exert effort for others. Furthermore, these brain activations and functional connectivity were positively related to self-reported motivation.Conclusions: These findings show altered motivation during effort-based decisionmaking in individuals with the mild depressive state, particularly with higher motivation for others. Thus, this suggests that motivational behaviors and prefrontal-striatal circuitry are altered in individuals with SD, which can be utilized to discover treatment targets and develop strategies to address mental illness caused by motivation disorders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Altered motivation of effortful decision‐making for self and others in subthreshold depression

Rong

Dong

Zheng

et al. 2022

Depression and Anxiety

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“… 4 Depressive symptoms seriously affect a person’s quality of life and cause changes in feelings, thoughts, motivation, and the ability to handle daily activities and functions. 5 6 Globally, depression resulted in 43 million years of living with a disability (YLDs) in 2017 7 and accounted for 12.1% of total YLDs. 8 From 2008 to 2015, the prevalence of depressive symptoms in middle-aged and elderly people was approximately 32%–37%.…”

Section: Introductionmentioning

confidence: 99%

“…Depression, the second leading cause of disability in China, has become an important public health problem 4. Depressive symptoms seriously affect a person’s quality of life and cause changes in feelings, thoughts, motivation, and the ability to handle daily activities and functions 5 6. Globally, depression resulted in 43 million years of living with a disability (YLDs) in 20177 and accounted for 12.1% of total YLDs 8.…”

Section: Introductionmentioning

confidence: 99%

Visual impairment and depression in China: a 7-year follow-up study from national longitudinal surveys

Zhao

Liu

et al. 2022

BMJ Open

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ObjectivesTo explore the longitudinal association between visual impairment (VI) and depression among adults 45 years and older in China based on a nationally representative follow-up dataset.SettingParticipants in China from the China Health and Retirement Longitudinal Study were included.ParticipantsA total of 6748 participants from two waves of the China Health and Retirement Longitudinal Study 2011–2018 were included for analysis by age group.Primary and secondary outcome measuresVI and depression were defined by self-diagnosis and the Center for Epidemiological Studies Depression Scale-10, respectively. Lagged dependent variable regression models with ordinary least squares estimation were used to evaluate the association between VI and depression. Age was divided into three groups, that is, 45–54, 55–64, and 65 years and older, to explore the relationship between VI and depression in different age groups.ResultsIn our study sample, VI remarkably predicted an increase in depressive scores. The magnitude of depressive scores increased among those with VI points greater than 3.517 (β=3.517; 95% CI=2.697 to 4.331) points than those without VI in the 7-year follow-up. Significant relationships were also found between VI and depression in the three age groups in the sensitivity analysis.ConclusionVI was associated with an increase in depression scores over a 7-year period. Female respondents, low educational attainment and high alcohol intake significantly predicted an increase in depressive status.

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Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

Li,

Kuang,

Liu

et al. 2024

Human Brain Mapping

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Imaging studies of subthreshold depression (StD) have reported structural and functional abnormalities in a variety of spatially diverse brain regions. However, there is no consensus among different studies. In the present study, we applied a multimodal meta‐analytic approach, the Activation Likelihood Estimation (ALE), to test the hypothesis that StD exhibits spatially convergent structural and functional brain abnormalities compared to healthy controls. A total of 31 articles with 25 experiments were included, collectively representing 1001 subjects with StD. We found consistent differences between StD and healthy controls mainly in the left insula across studies with various neuroimaging methods. Further exploratory analyses found structural atrophy and decreased functional activities in the right pallidum and thalamus in StD, and abnormal spontaneous activity converged to the middle frontal gyrus. Coordinate‐based meta‐analysis found spatially convergent structural and functional impairments in StD. These findings provide novel insights for understanding the neural underpinnings of subthreshold depression and enlighten the potential targets for its early screening and therapeutic interventions in the future.

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Depression and the willingness to expend cognitive and physical effort for rewards: A systematic review

Cited by 38 publications

References 56 publications

Altered motivation of effortful decision‐making for self and others in subthreshold depression

Altered motivation of effortful decision‐making for self and others in subthreshold depression

Visual impairment and depression in China: a 7-year follow-up study from national longitudinal surveys

Structural and functional brain alterations in subthreshold depression: A multimodal coordinate‐based meta‐analysis

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