Depression, anxiety, and loneliness among adolescents and young adults with IBD in the UK: the role of disease severity, age of onset, and embarrassment of the condition

Qualter, Pamela; Rouncefield‐Swales, Alison; Bray, Lucy; Blake, Lucy; Allen, SJ; Probert, Chris; Crook, Kay; Carter, Bernie

doi:10.1007/s11136-020-02653-9

Cited by 31 publications

(11 citation statements)

References 52 publications

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“…UC is a common digestive disease that may severely affect the quality of life and mood of the patients due to long-term abdominal pain, diarrhea, bloody stools, and so on [ 20 , 21 ]. Moxibustion therapy obtains its curative effect by thermal stimulation to acupoints generated by the burning of moxa.…”

Section: Discussionmentioning

confidence: 99%

Moxibustion Inhibits the Expression of Colonic NLRP3 through miR7/RNF183/NF-κB Signaling Pathway in UC Rats

Yang

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Moxibustion has been recognized as an effective approach for ulcerative colitis, yet its mechanism is not clear. The research aimed to investigate the influence of moxibustion on the activation of NLRP3 inflammasome and its mechanism in treating ulcerative colitis by observing miR7/RNF183 inducing IκB α ubiquitination to regulate NF-κB signaling pathway in an ulcerative colitis rat model. Methods. An ulcerative colitis rat model was established by unlimited access to self-administration of 3.5% (w/v) dextran sulfate sodium solution. Mild moxibustion was applied to bilateral Tianshu points (ST25) in the moxa-stick moxibustion group; rats in the control group were intervened by intraperitoneal injection of ubiquitination inhibitor, MG132. The disease activity index was determined at the end of the intervention; colon injury was observed and scored after hematoxylin-eosin staining; the immunohistochemical method was adopted to detect the expressions of colonic IL-1β and NLRP3 proteins; Western blot determined the expressions of RNF183, IκB α, and NF-κB p65 proteins in the colon; the immunofluorescence test was used to observe the coexpression of IκB α/ubiquitin and IκB α/RNF183 proteins in the colon; immunoprecipitation assay was adopted to observe the interaction between IκB α and RNF183 proteins; and quantitative real-time polymerase chain reaction determined the expression of colonic miR7. Results. Moxibustion lowered the disease activity index, manifesting as restored colonic tissue and reduced inflammatory reaction, and decreased expression levels of NLRP3 and IL-1β proteins, compared with the model group. It also reduced colonic expression of NF-κB p65 protein, together with the increased level of IκB α protein and weaker expression levels of ubiquitin and RNF183 proteins and mRNAs and stronger expression of miR7. There were no significant differences between the moxa-stick moxibustion group and the control group except the expressions of RNF183 protein and mRNA and miR7. Conclusion. Moxibustion encourages the recovery of colon injury probably by regulating the expression of NLRP3 protein in ulcerative colitis rats through miR7/RNF183/NF-κB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Moxibustion Inhibits the Expression of Colonic NLRP3 through miR7/RNF183/NF-κB Signaling Pathway in UC Rats

Yang

Zhao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…All ndings will be included in a narrative review. Studies which report on clinical or speci c subpopulations, such as individuals with in ammatory bowel disease (44) or young adults with Type 1 diabetes (42), may be summarised separately to studies which focus on community samples. The reporting of our results will be guided by our research questions.…”

Section: Summarising Of Resultsmentioning

confidence: 99%

Loneliness in Young Adulthood: a Protocol for a Scoping Review of the Quantitative and Qualitative Literature.

Kirwan

Ó’Súilleabháin

Burns

et al. 2021

Preprint

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BackgroundLoneliness refers to the distressing feeling that accompanies the experience of perceiving the quantity or quality of one’s social relationships as inadequate (1). There is increasing recognition of the prevalence of loneliness in young adults. Despite this, there is no existing scoping review on loneliness in young adulthood. Young adults (18-25 years) are in a critical life stage involving diverse social, demographic, biological and cognitive transitions which may affect the development of loneliness. Evidence that loneliness is a risk factor for poorer mental and physical health further emphasises the need to understand the experience in this age group. Therefore, the aim of our scoping review is to provide a summary of the quantitative and qualitative literature on loneliness in young adulthood. MethodsThe proposed scoping review will follow the Joanna Briggs Institute methodology and Arksey and O’Malley’s (2005) framework for scoping reviews. Peer-reviewed journal articles and grey literature in the form of reports or difficult-to-locate studies will be identified by: (a) electronic database searching, (b) contacting national and international researchers in the field, and (c) by posting general requests for relevant information on Twitter. We will include all study designs published in English from 2000 to 2021 where loneliness (defined as subjective) is a key focus of the work and the mean age of participants is ≥ 18 and ≤ 25 years. Editorials, commentaries, opinion pieces, dissertations, and book chapters will be excluded. Articles will be selected for inclusion following screening of titles/abstracts succeeded by full-text screening. Results will be presented in a narrative form to provide a descriptive summary of the literature on loneliness in young adults.DiscussionThe results of this scoping review will provide an up-to-date overview of available research related to loneliness in young adults and will inform our future research in the area. Results will be shared through a peer-reviewed journal publication and conference presentations. RegistrationThis protocol is registered with the Open Science Framework (OSF) available at: https://osf.io/jfcmp.

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“…However, except for the mental health outcomes, for which the influence of vitamin D supplementation has been studied so far, there are some reports revealing that bowel diseases are also associated with other mental health outcomes, which include self-esteem [ 45 ], loneliness [ 46 ], feeling worried [ 47 ], stress [ 48 ], and suicidal behavior in IBD patients [ 49 ], as well as well-being [ 50 ], self-esteem [ 51 ], feeling worried [ 52 ], stress [ 53 ], hopelessness [ 54 ], and suicidal behavior in IBS patients [ 55 ]. There is an urgent need to conduct studies to determine whether vitamin D supplementation can improve the other mental health conditions associated with IBD or IBS.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review

et al. 2021

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Inflammatory bowel diseases (IBDs) and irritable bowel syndrome (IBS) are associated with decreased quality of life and mental health problems. Among various approaches to supportive therapy that aims to improve mental health in affected individuals, vitamin D supplementation is considered to be an effective method which may also be beneficial in alleviating the symptoms during the course of IBDs and IBS. The aim of the present study was to conduct a systematic review of the literature presenting the data regarding the influence of vitamin D supplementation on mental health in adults with inflammatory and functional bowel diseases, including IBDs and IBS. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (Registration number CRD42020155779). A systematic search of the PubMed and Web of Science databases was performed, and the intervention studies published until September 2021 were included. The human studies eligible to be included in the review should have described any intervention involving vitamin D as a supplement in a group of adult patients suffering from IBDs and/or IBS and should have assessed any component of mental health, but studies presenting the effects of combined supplementation of multiple nutrients were excluded. After eliminating the duplicates, a total of 8514 records were screened and assessed independently by two researchers. Further evaluation was carried out on the basis of title, abstract, and full text. Finally, 10 studies (four for IBDs and six for IBS) were selected for the current systematic review, and their quality was assessed using the Newcastle–Ottawa Scale (NOS). The studies analyzed the influence of various doses of vitamin D on bowel diseases, compared the results of vitamin D supplementation with placebo, or administered specific doses of vitamin D to obtain the required level in the blood. Supplementation was performed for at least 6 weeks. The analyzed mental health outcomes mainly included disease-specific quality of life/quality of life, anxiety, and depression. The majority of studies (including high-quality ones) confirmed the positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, which was proven by all research works evaluating anxiety and depression and by the majority of research works evaluating quality of life. Although the studies followed different dosage regimens and supplementation protocols, the positive influence of vitamin D on mental health was found to be consistent. The number of studies on patients suffering from ulcerative colitis and the availability of trials randomized against the placebo group was low in the current review, which is considered to be a limitation of the present study and could also reflect the final outcome of the analysis. The conducted systematic review established the positive effect of vitamin D supplementation on the mental health of IBD and IBS patients, but this result requires further investigation, particularly in relation to other mental health outcomes.

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Depression, anxiety, and loneliness among adolescents and young adults with IBD in the UK: the role of disease severity, age of onset, and embarrassment of the condition

Cited by 31 publications

References 52 publications

Moxibustion Inhibits the Expression of Colonic NLRP3 through miR7/RNF183/NF-κB Signaling Pathway in UC Rats

Moxibustion Inhibits the Expression of Colonic NLRP3 through miR7/RNF183/NF-κB Signaling Pathway in UC Rats

Loneliness in Young Adulthood: a Protocol for a Scoping Review of the Quantitative and Qualitative Literature.

Vitamin D Supplementation and Mental Health in Inflammatory Bowel Diseases and Irritable Bowel Syndrome Patients: A Systematic Review

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