Depression Comorbidity and Antidepressant Use in Veterans With Chronic Hepatitis C

Nelligan, Julie; Loftis, Jennifer M.; Matthews, Annette M.; Zucker, Betsy L.; Linke, Alex; Hauser, Péter

doi:10.4088/jcp.v69n0514

Cited by 42 publications

(30 citation statements)

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“…The results confirmed that psychiatric co-morbidity is associated with HCV infection independent of substance use and alcohol disorders. While others have previously found such an association (Amodio et al, 2012;Butt et al, 2006;Dominitz et al, 2005;Nelligan et al, 2008;Osher et al, 2003), our study demonstrated this in a large inner city substance misuse population. Although the difference is small, the results suggest that the prevalence of HCV infection is high in both groups and therefore HCV infection is a considerable problem.…”

Section: Discussioncontrasting

confidence: 76%

“…Osher et al (2003) reported that patients with severe mental illness are up to 10 times more likely to acquire HCV infection than the general population. A multi-sited study done by the US National Institute of Mental Health found that approximately 20% of adults who have severe mental illness also have HCV compared to about 2% of the HCV infected general population (Nelligan et al, 2008). The existence of HCV infection among people with substance misuse disorders adds challenges to health care service providers and warrant special attention.…”

Section: Introductionmentioning

confidence: 98%

“…This co-morbidity has been discovered in various drugs, and has been found to be associated with negative outcomes of persistence and severity of drug use and psychiatric disorders (Conway et al, 2006;Compton et al, 2005;Glantz et al, 2009;Hasin et al, 2007;WHO, 2004). Increasing evidence suggested that patients with psychiatric illness have a high prevalence of HCV infection (Dominitz et al, 2005;Nelligan et al, 2008;Osher et al, 2003). Osher et al (2003) reported that patients with severe mental illness are up to 10 times more likely to acquire HCV infection than the general population.…”

Section: Introductionmentioning

confidence: 99%

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Psychiatric co-morbidity among subjects with heroin and cocaine use disorders and its association with HCV infection

Wang

Finch

Wolff

2013

Journal of Substance Use

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Aim: This study aims to determine whether psychiatric co-morbidity is associated with HCV infection in a substance misuse population. Methods: We identified all subjects in the National Drug Treatment Monitoring System (NDTMS) during the period January 2007-December 2010 for whom information was recorded which identified their psychiatric co-morbidity status and their HCV status. Multivariate analysis was used to identify risk factors that could predict HCV infection. Results and conclusions: The HCV prevalence rate was 32%. HCV infected subjects were younger (21.4% versus 23.1%) when they first started to use drugs, they were more likely to be white (85.1% versus 13.1%) and male (74% versus 72.6%), to have urgent housing problems (13.0% versus 9.7%), to inject (42.8% versus 18.8%), and to share injecting paraphernalia (35.4% versus 9.2%). After adjusting for demographics and drug and alcohol use behaviours, the Odds Ratio of psychiatric co-morbidity for HCV infection was 1.33 (95% CI 1.01-1.75). The results suggest that psychiatric co-morbidity is associated of HCV infection. Clinical implications: It is important to take psychiatric co-morbidity into account when treating these patients and designing intervention strategies.

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Section: Discussioncontrasting

confidence: 76%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Psychiatric co-morbidity among subjects with heroin and cocaine use disorders and its association with HCV infection

Wang

Finch

Wolff

2013

Journal of Substance Use

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“…This disparity occurring in the VA (an integrated system) suggests that this difference is not entirely due to barriers to access to care. Both psychiatric and medical comorbidity also appear to have a significant impact 33 and in this study was associated with delay in depression treatment initiation regardless of HIV serostatus. Similarly, coronary artery disease was also associated with delay in depression treatment, perhaps suggesting the impact of competing demands on primary care providers 34 .…”

Section: Discussionmentioning

confidence: 67%

Time to Depression Treatment in Primary Care Among HIV-infected and Uninfected Veterans

et al. 2010

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“…Based on Beck Depression Inventory-Second Edition (BDI-II) scores, a significant proportion of veterans with HCV experienced moderate-to-severe depressive symptoms (34%). Many of the affected individuals continued to experience depressive symptoms despite receiving antidepressant medications [77]. IFN are naturally-produced cy-tokines which have also been synthesized for therapeutic purposes including treatment of a variety of cancers and viral infections.…”

Section: Viral Hepatitismentioning

confidence: 99%

Psychiatric Aspects of Infectious Diseases

Mufaddel¹,

Omer²,

Salem³

2014

OJPsych

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Psychiatric symptoms can be associated with several systemic and central nervous system infections and they can be the initial presenting symptoms, occurring in the absence of neurological symptoms in some disorders as in some cases of viral encephalitis. They could also be part of the clinical picture in other cases such as psychosis or mood symptoms secondary to brucellosis or toxoplasmosis. Late-onset neuropsychiatric complications may also occur several years following the infection such as in the case of subacute sclerosing panencephalitis due to measles. Some Infectious diseases may have possible etiological role for major psychiatric disorders, based on yet unconfirmed reports for viral infectious diseases (e.g. Influenza virus and HSV-1) which are thought to have risk for developing schizophrenia and psychosis. Neuropsychiatric adverse effects can occur due to drugs (e.g. mefloquine, interferon-alpha) that are used for treatment of infectious diseases. Psychiatric symptoms can also be reactivated resulting from chronic, complicated and serious infections such as HIV that can lead to depression, anxiety or adjustment disorders, although CNS involvement can also be a possible etiological factor. Patients suffering from primary and severe psychiatric disorders are at increased risk of contracting infection; that is mainly related to high risk behaviors in patients with mania or schizophrenia. It is also important to consider that the co-occurrence of psychiatric symptoms and infection can be incidental (i.e. infectious diseases can occur in psychiatric patients regardless of the above mentioned factors). Early identification of the underlying etiology for organic/secondary psychiatric symptoms is essential for appropriate intervention and early treatment of the primary condition that could be the etiology of psychiatric symptoms so as to avoid unnecessary long-term psychiatric treatment and to avoid complications of possible misdiagnosis or delayed diagnosis of the primary condition.

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Depression Comorbidity and Antidepressant Use in Veterans With Chronic Hepatitis C

Cited by 42 publications

References 0 publications

Psychiatric co-morbidity among subjects with heroin and cocaine use disorders and its association with HCV infection

Psychiatric co-morbidity among subjects with heroin and cocaine use disorders and its association with HCV infection

Time to Depression Treatment in Primary Care Among HIV-infected and Uninfected Veterans

Psychiatric Aspects of Infectious Diseases

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