Depression following acute coronary syndrome: a Danish nationwide study of potential risk factors

Joergensen, T; Maartensson, Solvej; Ibfelt, Else Helene; Joergensen, Martin Balslev; Wium‐Andersen, Ida Kim; Wium‐Andersen, Marie Kim; Prescott, Eva; Andersen, Per Kragh; Osler, Merete

doi:10.1007/s00127-016-1275-7

Cited by 16 publications

(13 citation statements)

References 64 publications

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“…Our analyses confirm previous findings of a relationship between CVD and depression [2][3][4][5]. Mental vulnerability explained the same proportion of the relationship between CVD and depression as all other potential confounders combined including socio-demographic factors and health-related behaviors.…”

Section: Discussionsupporting

confidence: 88%

“…Today, a large proportion of patients survive cardiovascular disease (CVD) due to considerable improvements in treatment; however, CVD patients are at high risk of developing mental disorders, such as anxiety and depression [1][2][3][4][5]. Health behavioral patterns and biological pathways including exogenous stressors and physiological stress response have been suggested to partly explain the relationship between CVD and depression [2,6].…”

Section: Introductionmentioning

confidence: 99%

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The impact of mental vulnerability on the relationship between cardiovascular disease and depression

et al. 2020

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Background. The mechanisms linking cardiovascular disease (CVD) and depression are still not established. We investigated the impact of mental vulnerability on the relationship between CVD and depression. Methods. A total of 19,856 individuals from five cohorts of random samples of the background population in Copenhagen were followed from baseline (1983–2011) until 2017 in Danish registries. Additive hazard and Cox proportional hazard models were used to analyze the effects of confounding by mental vulnerability as well as interactions between mental vulnerability and CVD on the risk of depression. Results. During follow-up, 15.3% developed CVD, while 18.1% experienced depression. A strong positive association between CVD and depression (hazard ratio: 3.60 [95% confidence intervals (CI): 3.30; 3.92]) corresponding to 35.4 (95% CI: 31.7; 39.1) additional cases per 1,000 person-years was only slightly attenuated after adjustment for mental vulnerability in addition to other confounders. Synergistic interaction between CVD and mental vulnerability was identified in the additive hazard model. Due to interaction between CVD and mental vulnerability, CVD was associated with 50.9 more cases of depression per 1,000 person-years among individuals with high mental vulnerability compared with individuals with low mental vulnerability. Conclusions. Mental vulnerability did not explain the strong relationship between CVD and depression. CVD was associated with additional cases of depression among individuals with higher mental vulnerability indicating that this group holds the greatest potential for intervention, for example, in rehabilitation settings.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

The impact of mental vulnerability on the relationship between cardiovascular disease and depression

et al. 2020

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“…The latter categorization was intended to assess whether depression that was symptomatic at the time of somatic disease onset has a different effect on mortality from depression possibly in remission. Current depression was defined as having had a hospital contact for depression within 100 days prior to the specific somatic disease onset in line with previous publications using the same dataset . Previous depression referred to having a depression diagnosis prior to somatic disease diagnosis but not current depression.…”

Section: Methodsmentioning

confidence: 99%

Mortality in unipolar depression preceding and following chronic somatic diseases

Koyanagi

Köhler‐Forsberg

Benros

et al. 2018

Acta Psychiatr Scand

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“…The reason for slightly higher risks compared with the reference literature (female: OR = 1.79; widowed: OR = 2.34) might be due to our inclusion criteria. These variables weigh more in determining a first-incident episode compared with a recurrent one (Joergensen et al, 2016). Interestingly, the effect of sex disappeared after controlling the living status, but this could also be due to the fact that women are more likely to be widowed (female: n = 10, 20.4%; male: n = 9, 4.1%; F[1, 267] = 16.042; p < 0.001).…”

Section: Sociodemographic Variablesmentioning

confidence: 99%

“…Little is known about the etiology and the characteristics of incident depression. It remains unclear to what extent depression after ACS is a para-physiological transient reaction to a life-threatening event or a clinical entity that deserves to be treated (Hare et al, 2014;Joergensen et al, 2016;Parker et al, 2019;Spijkerman et al, 2005a).…”

mentioning

confidence: 99%

Temperament and Depression After a First Acute Coronary Syndrome

et al. 2019

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Few studies assess the role of personality styles in predicting the onset of depression among cardiac patients. This study evaluates whether temperament and character can represent a risk factor for the development of incident first-ever depressive episodes in patients at their first acute coronary syndrome (ACS). Two hundred sixty-seven (72.1%) subjects (male) completed the Temperament and Character Inventory (TCI) a few days after the cardiac event. At baseline and after 1, 2, 4, 6, 9, 12, and 24 months of follow-up, the participants completed the Primary Care Evaluation of Mental Disorder (PRIME-MD) and the Hospital Anxiety and Depression Scale to establish the presence of a depressive episode and its severity. During the follow-up, 61 (22.8%) participants developed a depressive episode. Temperamental risk factors for incident depression were scored high on novelty seeking and harm avoidance at the TCI. Given the detrimental effect of depression on cardiac prognosis, clinicians should take temperament variables into account when determining the treatment plans of their patients with ACS.

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Depression following acute coronary syndrome: a Danish nationwide study of potential risk factors

Abstract: Our results indicate that first time and recurrent depression following acute coronary syndrome have different risk profiles. This is important knowledge that may be used to focus future interventions for prevention and detection.

Cited by 16 publications

References 64 publications

The impact of mental vulnerability on the relationship between cardiovascular disease and depression

The impact of mental vulnerability on the relationship between cardiovascular disease and depression

Mortality in unipolar depression preceding and following chronic somatic diseases

Temperament and Depression After a First Acute Coronary Syndrome

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