Mortality in unipolar depression preceding and following chronic somatic diseases

Koyanagi, Ai; Köhler‐Forsberg, Ole; Benros, Michael E.; Laursen, Thomas Munk; Haro, Josep María; Nordentoft, Merete; Hjorthøj, Carsten

doi:10.1111/acps.12899

Cited by 25 publications

(10 citation statements)

References 38 publications

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“…Patients with psychiatric disorders tend to be nonadherent to treatment because of poor reasoning and lack of insight regarding their illness and therapy. Moreover, preexisting psychiatric disorders may result in the delayed detection of physical diseases until an advanced stage, when prognosis is poor [ 7 , 8 ]. Mounting evidence suggests that anxiety or depression are associated with aging-associated physical illnesses and worsening treatment outcomes are increasing [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease

Huang

Chang

Lin

et al. 2021

IJERPH

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The relationship between preexisting major psychiatric disorders and outcomes of spine surgery for degenerative thoracic/lumbar disease remains unclear. A 5% subset of inpatients was randomly selected from the Taiwan National Health Insurance Research Database. A total of 10,109 inpatients aged 18 years or over with degenerative thoracic/lumbar disease and underwent spine surgery met inclusion criteria. Major psychiatric disorders diagnosed by psychiatrists preceding index surgery, including anxiety disorder, depression disorder, bipolar disorder, schizophrenia and dementia, were identified. The prevalence of psychiatric disorders, and their differential risks on in-hospital and post-discharge outcomes were examined. 10.4% had major psychiatric disorders, of which depression (6.6%) and anxiety (4.9%) were most common. Logistic regression revealed increased risks of ventilator use in depression (OR = 1.62, 95% CI = 1.04–2.54, p < 0.05), extended hospitalization length in bipolar (OR = 1.77, 95% CI = 1.08–2.89, p < 0.05), and higher rehabilitation utilization in depression (OR = 1.25, 95% CI = 1.06–1.47, p < 0.01) and bipolar (OR = 1.69, 95% CI = 1.04–2.76, p < 0.05). Those patients with anxiety had a decreased risk of longer hospitalization duration (OR = 0.77, 95% CI = 0.60–0.98, p < 0.05), while those with dementia and schizophrenia had no change in risks. Preoperative recognition of major psychiatric disorders for risk and treatment assessment is suggested as people with preexisting depression or bipolar disorder have worse outcomes after spine surgery.

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Section: Introductionmentioning

confidence: 99%

Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease

Huang

Chang

Lin

et al. 2021

IJERPH

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“…Besides the association between MD and mental distress, we also found that older people, women, smokers and subjects with one or more chronic diseases had higher mental distress and hence worse mental health. Poor physical health is often present in people with mental illness, increasing their mortality risk (Koyanagi et al , 2018). This is the reason behind the need for clinical integration of both pharmacological and nutritional intervention in caring for people with mental illness, especially those with comorbidities (Teasdale et al , 2018).…”

Section: Discussionmentioning

confidence: 99%

Mediterranean diet and mental distress: “10,001 Dalmatians” study

Salvatore

Relja

Filipčić

et al. 2019

BFJ

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Purpose The impact of eating habits on mental health is gaining more attention recently. The purpose of this paper is to investigate the association between mental distress and the Mediterranean diet (MD) in a community-dwelling adult population of Dalmatia, Croatia. Design/methodology/approach Participants from the “10,001 Dalmatians” study from the Island of Korcula and the City of Split were included (n=3,392). Lifestyle habits were investigated using a self-administered questionnaire, while mental distress was evaluated using the General Health Questionnaire-30 (GHQ-30) in a cross-sectional design. MD compliance was assessed using the Mediterranean Diet Serving Score. Multivariate linear regression analysis was used in the analysis. Findings MD compliance was associated with lesser mental distress (ß=−1.96, 95% CI −2.75, −1.17; p<0.001). Inverse association was found between mental distress and higher intake of fruits (ß=−0.64; 95% CI −0.89, −0.39; p<0.001), vegetables (ß=−0.39; 95% CI −0.65, −0.13; p=0.003), olive oil (ß=−0.30; 95% CI −0.56, −0.04; p=0.022) and legumes (ß=−0.83; 95% CI −1.66, 0.00; p=0.049). Mental distress was more intense in women, older participants, those with worse material status, subjects with previously diagnosed chronic diseases and in current smokers. Originality/value This study suggests beneficial association of MD and overall mental health, offering important implications for public health provisions. Since the literature search did not reveal any previous study on the association between the MD and GHQ-based mental distress in the general population, this study delivers interesting results and fills this knowledge gap.

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“…The latter have important clinical implications since depression may dramatically contribute to worsen those diseases and in general have an impact on overall health [164]. Indeed, comorbid depression has been associated with worse prognosis and increased mortality [165,166] and with a higher risk of developing other diseases later in life [167]. Several mechanisms have been proposed to explain the co-occurrence of depression with the comorbidities mentioned above, including treatment-induced morbidity, behavioral and psychological factors, but also underlying biological processes [163].…”

Section: Mdd Comorbidities and Plateletsmentioning

confidence: 99%

Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

Izzi

Tirozzi

Cerletti

et al. 2020

IJMS

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Alongside their function in primary haemostasis and thrombo-inflammation, platelets are increasingly considered a bridge between mental, immunological and coagulation-related disorders. This review focuses on the link between platelets and the pathophysiology of major depressive disorder (MDD) and its most frequent comorbidities. Platelet- and neuron-shared proteins involved in MDD are functionally described. Platelet-related studies performed in the context of MDD, cardiovascular disease, and major neurodegenerative, neuropsychiatric and neurodevelopmental disorders are transversally presented from an epidemiological, genetic and functional point of view. To provide a complete scenario, we report the analysis of original data on the epidemiological link between platelets and depression symptoms suggesting moderating and interactive effects of sex on this association. Epidemiological and genetic studies discussed suggest that blood platelets might also be relevant biomarkers of MDD prediction and occurrence in the context of MDD comorbidities. Finally, this review has the ambition to formulate some directives and perspectives for future research on this topic.

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Mortality in unipolar depression preceding and following chronic somatic diseases

Abstract: A particularly high mortality risk was observed in the presence of prior depression for most somatic diseases. Future studies that assess the underlying mechanisms are necessary to adequately address the excessive mortality associated with comorbid depression.

Cited by 25 publications

References 38 publications

Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease

Prevalence and Outcomes of Major Psychiatric Disorders Preceding Index Surgery for Degenerative Thoracic/Lumbar Spine Disease

Mediterranean diet and mental distress: “10,001 Dalmatians” study

Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities

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