Depression in context of low neuroticism is a risk factor for stroke

Marijnissen, Radboud M.; Wouts, Lonneke; Schoevers, Robert A.; Bremmer, Marijke A.; Beekman, Aartjan T.F.; Comijs, Hannie C.; Voshaar, Richard C. Oude

doi:10.1212/wnl.0000000000000955

Cited by 14 publications

(10 citation statements)

References 36 publications

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“…An obvious hypothesis is that failures of emotion and mood regulation leading to depression in LOD in subjects with normal levels of neuroticism may stem from disease processes, in particular vascular disease, affecting the same neural circuits as implicated in neuroticism. This is consistent with the vascular depression hypothesis [45,52,53,54] and with the greater amount of WMHs, particularly in frontal areas, and greater impairments in executive functions in LOD than in EOD of similar age [for reviews, see [11,12]]. In our study 14 controls and 28 patients (14 EOD; 14 LOD) had MRI scans and were rated visually on the severity of WMHs according to the Fazekas scale [55].…”

Section: Discussionsupporting

confidence: 92%

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Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Gade

Kristoffersen²,

Kessing

2015

Psychopathology

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Background: The personality trait of neuroticism is strongly related to depression, but depression is etiologically heterogeneous. Late-onset depression (LOD) may be more closely related to vascular factors, and previous studies of neuroticism in LOD versus early-onset depression (EOD) have not been consistent. Method: We examined neuroticism, extraversion and perceived stress in 88 fully remitted depressed patients with a mean age of 60 years and with a history of hospitalization for major depressive disorder. Patients were divided into those with onset after and those with onset before 50 years of age (LOD and EOD, respectively), and the two groups were compared both with each other and with matched control groups of healthy subjects. Results: EOD patients showed increased levels of neuroticism in comparison with both LOD and matched controls, who did not differ. The association between age of onset and neuroticism was confirmed in analyses based on age of depression onset as a continuous variable. Conclusion: Neuroticism may be an etiological factor in EOD but not or less so in LOD. This finding contributes to the growing evidence for etiological differences between early- and late-onset late-life depression.

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Section: Discussionsupporting

confidence: 92%

“…In a 9-year follow-up [45], depression predicted stroke. However, in persons without preexistent cardiac disease, stroke was only predicted by depression in the absence of high neuroticism.…”

Section: Discussionmentioning

confidence: 99%

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Gade

Kristoffersen²,

Kessing

2015

Psychopathology

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“…So far there is only one study, a 9-year follow-up study of 2050 participants, Longitudinal Aging Study Amsterdam (LASA) by Marijnissen et al, which has discussed the effect of neuroticism on the relation between depression and future risk of stroke. The study concluded that older persons with depression and low level of neuroticism had a higher risk of developing stroke, thus indicating a negative interaction between depression and neuroticism in predicting future risk of CVD [19]. In contrast, our study demonstrates that there is an interaction between neuroticism and depression in predicting risk for CVD.…”

Section: Discussioncontrasting

confidence: 56%

“…However, to our knowledge, only one previous study has addressed the question of whether the effect of neuroticism on future risk of CVD differs in the presence of depression. This study, the Longitudinal Aging Study Amsterdam (LASA), reported that depression is only predictive for future stroke in the absence of high neuroticism [ 19 ]. The proposed hypothesis in LASA was that people with lower degree of neuroticism, had more vascular disease leading to incident cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of neuroticism on risk of cardiovascular disease in depressed persons - a Swedish population-based cohort study

Almas

Möller

Iqbal

et al. 2017

BMC Cardiovasc Disord

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BackgroundThe relationship between neuroticism, depression and cardiovascular disease (CVD) is complex and has so far not been studied in depth. The aim of this study was to determine if neuroticism is an effect-modifier in the association between depression and CVD. Data derived from a longitudinal cohort study on mental health, work and relations among adults (20–64 years), including 10,443 individuals. Depression was assessed using the Major Depression Inventory (MDI) and neuroticism by the Swedish Scale of Personality (SSP). Outcomes of cardiovascular disease were register-based from the National inpatient register.ResultsBoth depression (OR 1.9 (95%CI 1.4, 2.5)) and high levels of neuroticism (OR 1.2 (95%CI 1.1–1.3)) were associated with increased risk of CVD. The combined effect of depression and neuroticism on the risk of CVD revealed HRs ranging from 1.0 to 1.9 after adjusting for age and gender, socioeconomic position, prevalent hypertension and diabetes. Almost similar associations were seen after further adjustment for lifestyle factors.ConclusionNeuroticism increased the risk of CVD in depressed persons. We found synergistic interaction between neuroticism and depression status in predicting future risk of CVD.

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“…In persons without preexistent cardiac disease, depression was associated with future stroke but only in persons with low levels of neuroticism [ 94 ]. An unfavorable course of SUBD was found to be associated with smaller network sizes and higher levels of loneliness over time, especially in men and older participants [ 95 ].…”

Section: Major Findingsmentioning

confidence: 99%

The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings

et al. 2016

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The Longitudinal Aging Study Amsterdam (LASA) is an ongoing longitudinal study of older adults in the Netherlands, which started in 1992. LASA is focused on the determinants, trajectories and consequences of physical, cognitive, emotional and social functioning. The study is based on a nationally representative sample of older adults aged 55 years and over. The findings of the LASA study have been reported in over 450 publications so far (see www.lasa-vu.nl). In this article we describe the background and the design of the LASA study, and provide an update of the methods. In addition, we provide a summary of the major findings from the period 2011-2015.

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Depression in context of low neuroticism is a risk factor for stroke

Cited by 14 publications

References 36 publications

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression

Effect of neuroticism on risk of cardiovascular disease in depressed persons - a Swedish population-based cohort study

The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings

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