Depression in Elderly Hospitalized Patients With Medical Illness

Koenig, Harold G.; Meador, Keith G.; Cohen, Harvey Jay; Blazer, Dan G.

doi:10.1001/archinte.1988.00380090031009

Cited by 246 publications

(60 citation statements)

References 43 publications

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“…[8], [20], [21] and [22] Studies of elderly patients with medical illness in the United States indicate that MDD and other depressive disorders are present in 20% to 45% of those ill enough to require hospitalization. [8], [23], [24], [25] and [26] These figures contrast with those for MDD reported in healthy elders living in the community via the recent Epidemiologic Cachment Area studies that indicates rates of 0.1% to 0.8% in men and 0.6% to 1.8% in women 27. The fate of patients with depression in the medical setting is gloomy; many of these depressive disorders do not resolve once the patient leaves the hospital.…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Sertraline for Depression in Patients with CHF (SADHART-CHF): A randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure

Jiang

O’Connor

Silva

et al. 2008

American Heart Journal

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Background Sertraline, a selective serotonin-reuptake inhibitor (SSRI), has demonstrated substantial mood improvement in patients with post myocardial infarction or with unstable angina. The impact of sertraline on the prognosis and depression of patients with chronic heart failure (HF) and co-morbid major depressive disorder (MDD) is unknown. Method This is a prospective, randomized, double-blind, placebo-controlled study designed to assess the safety and efficacy of sertraline in the treatment of MDD in patients with HF. The study is designed also to examine the effects of treating depression on cardiac events and morbidity/mortality in HF patients. Approximately 500 men and women who are ≥45 years of age with current MDD and chronic systolic HF, characterized by left ventricular ejection fraction (LVEF) ≤45% and New York Heart Association (NYHA) class ≥ II comprise the study population. Eligible participants are randomized to either sertraline or placebo for a 12-week acute treatment phase. All patients, regardless of acute treatment phase completion, are followed routinely until the last subject completes 6-month follow-up. Quality of life and certain physiologic parameters, as well as pro-inflammatory and HF biomarkers, that may reflect the impact of sertraline in this particular population, are measured at baseline and at the end of the acute treatment phase. Conclusion Because of the high prevalence of depression and its significant adverse impact on prognosis of patients with ischemic heart disease and HF, the SADHART-CHF trial aims to assess the effects of sertraline on response of depression as well as on the cardiac prognosis of patients with HF.

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Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Sertraline for Depression in Patients with CHF (SADHART-CHF): A randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure

Jiang

O’Connor

Silva

et al. 2008

American Heart Journal

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“…Previous research has shown that primary care physicians overlook de- pression about 50 percent of the time. 27,28 If laws allowing assisted suicide require physicians to confirm a short life expectancy or to identify depression, these gaps between expectations and skills must be bridged. The finding that a substantial minority of physicians (32 percent) believe that other health care providers have a right to be informed of a patient's wish to commit suicide, whether or not the patient agrees, raises an additional question about assisted suicide.…”

Section: Discussionmentioning

confidence: 99%

Legalizing Assisted Suicide — Views of Physicians in Oregon

et al. 1996

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Oregon physicians have a more favorable attitude toward legalized physician-assisted suicide, are more willing to participate, and are currently participating in greater numbers than other surveyed groups of physicians in the United States. A sizable minority of physicians in Oregon objects to legalization and participation on moral grounds. Regardless of their attitudes, physicians had a number of reservations about the practical applications of the act.

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“…Depression was measured using the Geriatric Depression Scale (GDS) (Brink, 1983). Used in VA patients, the GDS has a sensitivity of 92%, specificity of 89%, and a negative predictive value of 99% (Koenig, Meador, Cohen, & Blazer, 1988a, 1988b. The GDS demonstrated a high degree of internal consistency (Cronbach's alpha = 0.94) and testretest reliability (r = 0.85) on subjects tested 1 week apart.…”

Section: Methodsmentioning

confidence: 99%

Risk for Acute Confusion on Hospital Admission

Wakefield

2002

Clin Nurs Res

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Elderly individuals are at risk for acute confusion (AC) during hospitalization. Using a prospective design, this study assessed the relationship between admission risk factors and subsequent development of AC in 117 elderly hospitalized patients. AC was ascertained using the NEECHAM Confusion Scale. Other measures included demographic data, cognitive status, physical function, laboratory data, medications, infections, activity, pain, and nursing acuity. The cumulative incidence estimate was 14%. Patients who developed AC were more likely to be admitted to the hospital from somewhere other than home, to have lower admission NEECHAM and MMSE scores, and to have restricted activity levels, an infection, and abnormal lab values. These patients were more cognitively and physically frail and may have been chronically undernourished and dehydrated on admission to the hospital. Nurses can be trained to routinely assess for acute confusion using easily implemented instruments incorporated into a research-based protocol.

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Depression in Elderly Hospitalized Patients With Medical Illness

Cited by 246 publications

References 43 publications

Safety and Efficacy of Sertraline for Depression in Patients with CHF (SADHART-CHF): A randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure

Safety and Efficacy of Sertraline for Depression in Patients with CHF (SADHART-CHF): A randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure

Legalizing Assisted Suicide — Views of Physicians in Oregon

Risk for Acute Confusion on Hospital Admission

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