Depression in Hiv-Infected Men

Porche, Demetrius J.; Willis, Danny G.

doi:10.1080/01612840600569658

Cited by 9 publications

(6 citation statements)

References 34 publications

(30 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Depression in an HIV-infected individual has been reported to largely hinder the patient’s life. In a study with 55 individuals, Porche and Willis (2006) found that 64% of the participants were diagnosed with depression, although only 42% reported symptoms 28 . The most common symptoms of depression reported in our survey were in agreement with studies from different countries 29 , 30 .…”

Section: Discussionmentioning

confidence: 99%

Depression and adherence to antiretroviral treatment in HIV-positive men in São Paulo, the largest city in South America: Social and psychological implications

Moraes¹,

Casseb²

2017

Clinics

View full text Add to dashboard Cite

OBJECTIVES:The aim of the present study was to investigate the prevalence of depression and adherence to antiretroviral treatment in two groups of individuals: men who have sex with men (MSM) and men who have sex with women (MSW).METHODS:Two hundred and sixteen participants (MSM=116; MSW=100) who visited the Clinics Hospital of the School of the Medicine of the University of São Paulo completed two independent surveys (the BECK Depression Inventory and an adherence self-declared questionnaire) to evaluate their depression status and adherence to antiretroviral treatment, respectively.RESULTS:The study highlighted a positive relationship between depression and low adherence to Highly Active Antiretroviral Therapy in these patients regardless of age and sexual orientation. In addition, MSM subjects were two times more prone than MSW subjects to develop depression symptoms. White or mixed race men showed 7.6 times greater adherence to treatment than black men. The probability of complete adherence to treatment was 3.8 times higher in non-depressed subjects than in depressed subjects regardless of their ethnicity.The chance of developing depression was 4.17 times higher for an individual with non-adherent behavior than for an adherent individual.CONCLUSIONS:Individuals with low adherence rates have proportionally higher depression rates. Depressed men tend to show less adherence to treatment. Black but not mixed race or white men show less adherence to Highly Active Antiretroviral Therapy and have a greater chance of developing depression, which directly interferes with adherence. The chances of developing depression are four times greater for a patient with non-adherent behavior than for a patient with adherent behavior.

show abstract

Section: Discussionmentioning

confidence: 99%

Depression and adherence to antiretroviral treatment in HIV-positive men in São Paulo, the largest city in South America: Social and psychological implications

Moraes¹,

Casseb²

2017

Clinics

View full text Add to dashboard Cite

show abstract

“…We have previously showed an increase of the related immunophilin FKBP12 in the deep gray matter of HIV patients, which we hypothesized to be a protective response (Christeff et al 1997; Bing et al 2001; Valente 2003; Porche and Willis 2006). …”

Section: Introductionmentioning

confidence: 97%

“…Since the prevalence of major depressive disorder (MDD) is significantly elevated in individuals infected with HIV, we sought to determine whether there was a relationship between HIV infection, MDD, and the expression of immunophilins in the frontal cortex (Reiter 2000; Valente 2003; Porche and Willis 2006). We have previously showed an increase of the related immunophilin FKBP12 in the deep gray matter of HIV patients, which we hypothesized to be a protective response (Christeff et al 1997; Bing et al 2001; Valente 2003; Porche and Willis 2006).…”

Section: Introductionmentioning

confidence: 99%

Differential Expression of Immunophilins FKBP51 and FKBP52 in the Frontal Cortex of HIV-Infected Patients with Major Depressive Disorder

Tatro

Everall²,

Masliah

et al. 2009

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

Patients infected with human immunodeficiency virus (HIV) have a higher risk of developing major depressive disorder (MDD) than the general population. Immunophilins FKBP51 and FKBP52 are expressed in cortical neurons and regulate the function of the glucocorticoid receptor (GR). Previous reports have shown that genetic variants in the FKBP5 gene encoding FKBP51 are linked to psychiatric disorders. We sought to determine whether immunophilins are upregulated in HIV infection. To determine whether FKBP52 and FKBP51 are associated with MDD and/or HIV, we compared protein and gene expression in autopsy tissues from the frontal cortical gray matter. The study cases were divided into five groups: control, MDD, MDD with psychosis, HIV + , and HIV + with MDD. Gene expression and protein levels were determined by real-time PCR and Western blot analysis of fresh frozen tissues. Genotyping of previously published alleles of the FKBP5 gene was also performed. We found correlation of upregulation of both immunophilins in the HIV-infected groups. In the HIV + population with MDD, FKBP4 expression is significantly higher while FKBP5 is more variable. After analyzing the FKBP5 gene for single nucleotide polymorphisms, we found that rs3800373 CC genotype is more frequent in the MDD and MDD/Psychosis groups. We hypothesized that the levels of FKBP51, as modulator of the nuclear translocation of GR, would be lower in MDD. Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV + MDD but not to HIV without MDD.

show abstract

“…Since depression was self-reported in the present study, respondents may have under-reported this psychological disorder. In a study with 55 individuals, only two-thirds of the participants who were diagnosed with depression actually reported symptoms of depression [40]. The beneficial effects of antiretroviral therapy and counselling could also be adduced to explain this finding [39].…”

Section: Discussionmentioning

confidence: 98%

Medication Adherence and Health Status in HIV Positive Patients in Akwa Ibom State, Nigeria

Jackson¹,

Umoh²,

Erah³

2020

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To assess medication adherence and health status in ambulatory HIV positive patients in Akwa Ibom State, Nigeria.Methods: The 7-item Adherence to Refills and Medication Scale (ARMS-7) was used to assess medication adherence among 500 HIV positive patients in three secondary health facilities in Akwa Ibom State, Nigeria. A single-item question (measuring self-rated health) and depression (CESD-R) questionnaire were also used to evaluate the patients. Recent CD4 count and viral load were obtained from the patients’ folders. The association between independent and dependent variables was evaluated using logistic regression analysis.Results: Only 56 (11.7%) respondents reported 100% adherence to their medications; 190 (39.7%) rated their health as being ‘very good’ and 51 (10.7%) reported being depressed. Respondents who were single were more likely to be nonadherent (aOR = 2.665, 95% CI = 1.336 - 5.318; p = 0.005), and the nonadherent patients were more likely to have lower CD4 cell counts (aOR = 0.998, CI = 0.996 – 0.999; p = 0.007). Those who rated their health as ‘fair’ or ‘poor’ were more likely to be nonadherent (aOR= 11.380, CI = 1.527 – 84.785; p=0.018) and depressed (aOR = 2.748, CI = 1.469 – 5.141; p = 0.002). Patients who were unemployed were more likely to rate their health as fair/poor (aOR = 1.890, CI = 1.197 – 2.985; p=0.006).Conclusion: This work has shown that even though most of the HIV positive patients perceive their health as being very good, their adherence to medications was poor which is directly related to their unemployment status. Intervention to improve adherence directed at socio-economic status of the individual patient is recommended. Keywords: Medication adherence; Depression; Self-rated health; Nigeria

show abstract

Depression in Hiv-Infected Men

Cited by 9 publications

References 34 publications

Depression and adherence to antiretroviral treatment in HIV-positive men in São Paulo, the largest city in South America: Social and psychological implications

Depression and adherence to antiretroviral treatment in HIV-positive men in São Paulo, the largest city in South America: Social and psychological implications

Differential Expression of Immunophilins FKBP51 and FKBP52 in the Frontal Cortex of HIV-Infected Patients with Major Depressive Disorder

Medication Adherence and Health Status in HIV Positive Patients in Akwa Ibom State, Nigeria

Contact Info

Product

Resources

About