Depression in patients with peripheral arterial disease: A systematic review

Brostow, Diana P.; Petrik, Megan L.; Starosta, Amy J.; Waldo, Stephen W.

doi:10.1177/1474515116687222

Cited by 66 publications

(51 citation statements)

References 77 publications

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“…Additionally, older patients with comorbidities have more depression and anxiety. 17,33 In this context, this study demonstrated that there was an association between these disorders and SAH, as reported in the available literature. 17,[34][35][36] However, it cannot be concluded whether SAH is one of the causes of these disorders in vulnerable patients, whether it is an aggravating factor, whether these disorders predispose patients to developing SAH, or whether there is actually a bidirectional relationship.…”

Section: Discussionsupporting

confidence: 83%

“…1,9,15,[17][18][19]35,36 Another point that it is indispensable to discuss is that both anxiety and depression are risk factors for CVD, such as AMI, stroke, and PAD. 1,15,17,30,[34][35][36][37][38] This could be because patients with anxiety/depression tend to have a less healthy lifestyle, with dietary errors and without physical exercise, 33,39 as was observed in our sample, the great majority of whom did not do regular physical exercise. However, in contrast to some other studies, 33,36 this factor did not affect the presence of depression.…”

Section: Discussionmentioning

confidence: 69%

“…17,20,21 Emphasizing the importance of our study even further, the literature suggests that there is a robust relationship between depression and PAD, 26,35,40 and also reports that perceptions of intermittent claudication and critical ischemia are factors that can predispose to depression. 26,32,33 Despite this, no significant association with chronic pain was identified in this group, even after adjustment in the logistic regression. Furthermore, while there is a vast body of literature discussing the association between these disorders and DM, this study did not detect any type of association with increased risk of developing DM due to changes to the body primarily provoked by depression, such as increased cortisol and, consequently, visceral adipose tissue, or with presence of endothelial dysfunction.…”

Section: Discussionmentioning

confidence: 70%

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Ansiedade e depressão em pacientes com doença arterial periférica internados em hospital terciário

et al. 2019

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Resumo Contexto Ansiedade e depressão são afecções neuropsiquiátricas altamente prevalentes e estão associadas a doenças crônicas, dor, perda de autonomia, dependência para realização de atividades rotineiras e solidão. A depressão, muitas vezes, possui relação de causa-consequência com outras doenças, como infarto agudo do miocárdio, hipertensão arterial sistêmica (HAS), diabetes mellitus e doença arterial periférica (DAP). Objetivos Estimar a frequência de ansiedade e depressão em pacientes de ambos os sexos com DAP, internados em hospital terciário. Métodos Trata-se de um estudo descritivo, transversal, com uma amostra não aleatória selecionada de forma consecutiva. Para avaliar a ansiedade e a depressão, foi utilizada a Escala Hospitalar de Ansiedade e Depressão (HADS) e, para a DAP, foi utilizado o índice tornozelo-braquial (ITB). Resultados A prevalência de ansiedade nesses pacientes foi de 24,4%, havendo associação entre ansiedade e renda familiar mensal, tabagismo e HAS. Já a prevalência de depressão foi de 27,6%, sendo verificadas associações entre depressão e sexo feminino, em união estável ou casada, que sobrevive com até um salário mínimo, não etilista e hipertensa. Conclusões É possível perceber que há uma alta prevalência de transtornos de ansiedade e depressão nos pacientes com DAP. Esses transtornos são subdiagnosticados e, consequentemente, não são devidamente tratados.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 70%

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Ansiedade e depressão em pacientes com doença arterial periférica internados em hospital terciário

et al. 2019

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“…10 Despite evidence of an association between depression and cardiovascular health independent of behavioral mechanisms, efforts aimed at understanding the pathophysiological processes linking depression and PAD remain limited. 15,21 One proposed mechanism involves modification of the immune response. PAD is a disease of atherosclerosis, with inflammation driving critical pathologic processes from plaque formation to thrombus rupture.…”

Section: Introductionmentioning

confidence: 99%

Depression severity is associated with increased inflammation in veterans with peripheral artery disease

et al. 2018

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The present study examines the association between depressive symptoms and inflammatory markers in peripheral artery disease (PAD) to better understand the mechanistic relationship between depression and PAD. A cross-sectional sample of 117 patients with PAD (97% male, 76% Caucasian) was recruited from the San Francisco Veterans Affairs Medical Center. Patients were categorized into three subgroups based upon current depressive symptom severity, as defined by Patient Health Questionnaire-8 scores: no symptoms (score of 0-4, n = 62), mild symptoms (score of 5-9, n = 33), and moderate/severe symptoms (score ≥ 10, n = 22). Serum levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (ICAM-1), and tumor necrosis factor-alpha (TNF-α) were assayed and log-transformed for multivariable analysis. To decrease the possibility of Type 1 errors, inflammatory markers were standardized and summed to create a total inflammatory score. In a multivariable analysis controlling for demographics, PAD severity, and atherosclerotic risk factors, mild and moderate/severe depressive symptoms were predictive of a higher total inflammatory score when compared to the group with no symptoms (mild symptoms p = 0.04, moderate/severe symptoms p = 0.007). Exploratory multivariable analyses of individual inflammatory markers found IL-6 levels were significantly higher in the moderate/severe symptoms group ( p = 0.006) than in the no symptoms group. Moreover, hs-CRP and ICAM-1 trended upwards with increasing depression severity. TNF-α was not associated with depression severity. We conclude that depressive symptom severity was independently associated with greater inflammation in PAD. Future research should examine the strength and directionality of this association through larger prospective cohort studies, as well as investigate the pathophysiological mechanisms responsible.

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“…Original papers calculating the subjective part of life quality are often affected by the psychological state of the atherosclerotic patient, which includes depression, anxiety and stress . (14,15,16) Causes of psycho-emotional disorders . (9,15,19,20) Impact of different treatment options on life quality was also assessed by different studies.…”

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confidence: 99%

Beyond the Arteries in Peripheral Artery Disease

et al. 2018

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Objectives. This study aimed to examine peripheral artery disease severity impact on psychological profile of arteriopathy patients.Material and methods. The prospective study included consecutive PAD patients admitted to the 2nd Department of Internal Medicine and the Department of Cardiology of the Emergency Clinical Hospital “Sf. Spiridon” Iasi, between January and September, 2017.Rezults. The group included 139 PAD patients, 80.6% male and 19.4% female, with an average age of 63.23±9.44 years. PAD stages have a very strong association with level of quality of life (p<0.0001). All Leriche-Fontaine classification categories were significantly associated with the depressive symptoms (p<0.0001). The stress level was moderate in stages IIA, IIB and III and extremely severe in the terminal stage. The prevalence of anxiety was lowest in incipient PADstages with the highest value in stage III.Conclusions. The fragment of the PhD study presented the psychological profile in the PAD staging and advocates a personalized, wide-ranging approach to the arteriopathy patient including pain and depressive-anxiety management, with amajor impact on the quality of life at terminal stages.

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Depression in patients with peripheral arterial disease: A systematic review

Cited by 66 publications

References 77 publications

Ansiedade e depressão em pacientes com doença arterial periférica internados em hospital terciário

Ansiedade e depressão em pacientes com doença arterial periférica internados em hospital terciário

Depression severity is associated with increased inflammation in veterans with peripheral artery disease

Beyond the Arteries in Peripheral Artery Disease

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