Depression in rheumatoid arthritis—underscoring the problem

Sheehy, Claire; Murphy, E; Barry, Maurice

doi:10.1093/rheumatology/kel231

Cited by 128 publications

(110 citation statements)

References 26 publications

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“…The relation between anxiety and RA is stronger than in depression patients. (6). In our study, depression and anxiety were present in 39% of RA patients, compared to 20% in RA and 5%-13% in the general population reported by other authors (7).…”

Section: Discussionsupporting

confidence: 42%

Mental health status can reflect disease activity in rheumatoid arthritis

Sokolović¹,

Dervisevic²,

Fisekovic

2014

Eur J Rheumatol

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Section: Discussionsupporting

confidence: 42%

Mental health status can reflect disease activity in rheumatoid arthritis

Sokolović¹,

Dervisevic²,

Fisekovic

2014

Eur J Rheumatol

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“…Moreover, it remains to be determined whether the EPC number abnormalities are state-or trait-dependent phenomena in affective disorders. Finally, our results also suggest that individuals should be screened for depression in future studies investigating EPC number and function in patient populations with cardiovascular risk factors (diabetes mellitus, 50 chronic renal failure, 51 smoking, 52 rheumatoid arthritis 53 ) or with definitive cardiovascular diseases (myocardial infarction, 9 stroke 10 ). It is especially crucial that the depression be considered an independent variable in such studies because depression is so highly comorbid with these cardiovascular conditions and diseases.…”

Section: Discussionmentioning

confidence: 74%

Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Döme

Teleki²,

Rihmer

et al. 2008

Mol Psychiatry

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Although depression is known to be an independent risk factor for cardiovascular disorders, the mechanisms behind this connection are not well understood. However, the reduction in the number of endothelial progenitor cells (EPCs) in patients with cardiovascular risk factors has led us to hypothesize that depression influences the number of EPCs. EPCs labeled with CD34, CD133 and vascular endothelial growth factor receptor-2 (VEGFR2) antibodies were counted by flow cytometry in the peripheral blood (PB) of 33 patients with a current episode of major depression and of 16 control subjects. Mature (CD34 þ /VEGFR2 þ ) and immature (CD133 þ / VEGFR2 þ ) EPC counts were decreased in patients (vs controls; P < 0.01 for both comparisons), and there was a significant inverse relationship between EPC levels and the severity of depressive symptoms (P < 0.01 for both EPC phenotypes). Additionally, we assayed the plasma levels of VEGF, C-reactive protein (CRP) and tumor necrosis factor (TNF)-a and observed significantly elevated TNF-a concentrations in patients (vs controls; P < 0.05) and, moreover, a significant inverse correlation between TNF-a and EPC levels (P < 0.05). Moreover, by means of a quantitative RT-PCR approach, we measured CD34, CD133 and VEGFR2 mRNA levels of PB samples and found a net trend toward a decrease in all the investigated EPC-specific mRNA levels in patients as compared with controls. However, statistical significance was reached only for VEGFR2 and CD133 levels (P < 0.01 for both markers). This is the first paper that demonstrates evidence of decreased numbers of circulating EPCs in patients with a current episode of major depression.

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“…Continuous pain, functional disability, tiredness, incapacity to work, economic limitations, and side effects of therapeutic drugs, which RA may bring about, can end up reducing these patients' quality of life. 2,3 Commonly associated with these biopsychosocial problems, psychiatric symptoms -especially depressive and anxiety ones -are relatively frequent in RA patients.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6][7][8][9] A recent review described a mean prevalence of 19% of depression among RA patients. 3 Anxiety symptoms and disorders have been less studied separately, because they are a very frequent dimension of depression, making it difficult to separate anxiety symptoms from depressive ones. 10 Some studies have found a prevalence of almost 40% of anxiety symptoms in RA.…”

Section: Introductionmentioning

confidence: 99%

Depressive symptoms in rheumatoid arthritis

Mella

Bértolo

Dalgalarrondo

2010

Rev. Bras. Psiquiatr.

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Objective: To determine the prevalence of depressive and anxiety symptoms in patients with rheumatoid arthritis (a chronic inflammatory disease) in comparison to a control group with osteoarthritis (a chronic non-inflammatory degenerative disease) and to identify the sociodemographic and clinical variables associated with depressive symptoms in these patients. Method: Sixty-two rheumatoid arthritis patients and 60 osteoarthritis patients participated in the study. Sociodemographic and clinical data were collected and the Hospital Anxiety and Depression Scale and the Disability Index of the Health Assessment Questionnaire were applied. Results: The prevalence of depressive symptoms was of 53.2% in rheumatoid arthritis and 28.3% in osteoarthritis (p = 0.005). The prevalence of anxiety symptoms was of 48.4% in rheumatoid arthritis and 50.0% in osteoarthritis (p = 0.859). The mean (and standard deviation) scores in the Disability Index of the Health Assessment Questionnaire were 1.4 (0.8) in rheumatoid arthritis and 1.4 (0.6) in osteoarthritis (p = 0.864). Rheumatoid arthritis patients with depressive symptoms had lower education and higher disease activity and functional disability. Conclusion: Although these two rheumatic diseases are similar in terms of the pain and functional disability that they cause, a significantly higher prevalence of depressive symptoms was found in rheumatoid arthritis patients. This difference might be explained by the hypothesis of a neuroimmunobiological mechanism related to cytokines in inflammatory diseases, which has been considered as a candidate to the development of depressive symptoms. Descriptors

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Depression in rheumatoid arthritis—underscoring the problem

Cited by 128 publications

References 26 publications

Mental health status can reflect disease activity in rheumatoid arthritis

Mental health status can reflect disease activity in rheumatoid arthritis

Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul

Depressive symptoms in rheumatoid arthritis

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