Depression of the photic after discharge of flash evoked potentials by physostigmine, carbaryl and propoxur, and the relationship to inhibition of brain cholinesterase

Mwanza, Jean-Claude; Finley, Dana B.; Spivey, Christopher L.; Graff, Jaimie E.; Herr, David W.

doi:10.1016/j.neuro.2007.09.004

Cited by 16 publications

(4 citation statements)

References 64 publications

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“…Earlier studies of experience-dependent plasticity in V1 reported that repeated exposure to a brief flash may elicit an oscillation that persists for some time after the stimulus terminates ("photic after-discharge") (Bishop and O'leary, 1936;Kimura, 1962). Despite this cortical expression of experiencedependent plasticity being characterized subsequently in greater detail (Shearer et al, 1976;Bigler et al, 1978;Uhlrich et al, 2005;Mwanza et al, 2008), its role has remained enigmatic. Collectively, these studies reveal that repeated presentation of visual stimuli induce a long-term response sensitization in V1 readily observable in local field potential (LFP) activity.…”

Section: Introductionmentioning

confidence: 99%

Theta Oscillations in Visual Cortex Emerge with Experience to Convey Expected Reward Time and Experienced Reward Rate

Zold

Shuler

2015

Journal of Neuroscience

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The primary visual cortex (V1) is widely regarded as faithfully conveying the physical properties of visual stimuli. Thus, experienceinduced changes in V1 are often interpreted as improving visual perception (i.e., perceptual learning). Here we describe how, with experience, cue-evoked oscillations emerge in V1 to convey expected reward time as well as to relate experienced reward rate. We show, in chronic multisite local field potential recordings from rat V1, that repeated presentation of visual cues induces the emergence of visually evoked oscillatory activity. Early in training, the visually evoked oscillations relate to the physical parameters of the stimuli. However, with training, the oscillations evolve to relate the time in which those stimuli foretell expected reward. Moreover, the oscillation prevalence reflects the reward rate recently experienced by the animal. Thus, training induces experience-dependent changes in V1 activity that relate to what those stimuli have come to signify behaviorally: when to expect future reward and at what rate.

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Section: Introductionmentioning

confidence: 99%

Theta Oscillations in Visual Cortex Emerge with Experience to Convey Expected Reward Time and Experienced Reward Rate

Zold

Shuler

2015

Journal of Neuroscience

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“…A full description of the component and mixture toxicology studies and additivity results has been previously published (Mwanza et al, 2008(Mwanza et al, , 2012 and those results for brain ChE activity are summarized in Table 2. The toxic endpoint of concern discussed here is relative cholinesterase inhibition (as percent of control mean), with increasing inhibition as dose increases.…”

Section: Example Of a Binary Mixture Of Carbaryl And Propoxur Brain mentioning

confidence: 99%

A four-step approach to evaluate mixtures for consistency with dose addition

Hertzberg

Pan

et al. 2013

Toxicology

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“…Changes in the ERG have been reported after exposure to methanol ( Eells et al, 1996 ; Eells et al, 2000 ), cholinesterase inhibition ( Jones et al, 1995 ), or lead ( Fox and Rubinstein, 1989 ). Additionally, changes in the central nervous system function of the visual system ( Boyes, 1992 ) have been shown following treatment with trichloroethylene ( Boyes et al, 2005 ), carbon disulfide ( Herr et al, 1992 ), 3,3′-iminodipropionitrile ( Herr et al, 1995 ), and carbaryl or propoxur ( Mwanza et al, 2008 ). The utility of these EP methods to detect, help localize the site of neurological dysfunction, and applicability to human neurology assures that such methods will continue to be applied in the future.…”

Section: Presentmentioning

confidence: 99%

The Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint

Herr

2021

Front. Toxicol.

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Neuroelectrophysiology is an old science, dating to the 18th century when electrical activity in nerves was discovered. Such discoveries have led to a variety of neurophysiological techniques, ranging from basic neuroscience to clinical applications. These clinical applications allow assessment of complex neurological functions such as (but not limited to) sensory perception (vision, hearing, somatosensory function), and muscle function. The ability to use similar techniques in both humans and animal models increases the ability to perform mechanistic research to investigate neurological problems. Good animal to human homology of many neurophysiological systems facilitates interpretation of data to provide cause-effect linkages to epidemiological findings. Mechanistic cellular research to screen for toxicity often includes gaps between cellular and whole animal/person neurophysiological changes, preventing understanding of the complete function of the nervous system. Building Adverse Outcome Pathways (AOPs) will allow us to begin to identify brain regions, timelines, neurotransmitters, etc. that may be Key Events (KE) in the Adverse Outcomes (AO). This requires an integrated strategy, from in vitro to in vivo (and hypothesis generation, testing, revision). Scientists need to determine intermediate levels of nervous system organization that are related to an AO and work both upstream and downstream using mechanistic approaches. Possibly more than any other organ, the brain will require networks of pathways/AOPs to allow sufficient predictive accuracy. Advancements in neurobiological techniques should be incorporated into these AOP-base neurotoxicological assessments, including interactions between many regions of the brain simultaneously. Coupled with advancements in optogenetic manipulation, complex functions of the nervous system (such as acquisition, attention, sensory perception, etc.) can be examined in real time. The integration of neurophysiological changes with changes in gene/protein expression can begin to provide the mechanistic underpinnings for biological changes. Establishment of linkages between changes in cellular physiology and those at the level of the AO will allow construction of biological pathways (AOPs) and allow development of higher throughput assays to test for changes to critical physiological circuits. To allow mechanistic/predictive toxicology of the nervous system to be protective of human populations, neuroelectrophysiology has a critical role in our future.

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Depression of the photic after discharge of flash evoked potentials by physostigmine, carbaryl and propoxur, and the relationship to inhibition of brain cholinesterase

Cited by 16 publications

References 64 publications

Theta Oscillations in Visual Cortex Emerge with Experience to Convey Expected Reward Time and Experienced Reward Rate

Theta Oscillations in Visual Cortex Emerge with Experience to Convey Expected Reward Time and Experienced Reward Rate

A four-step approach to evaluate mixtures for consistency with dose addition

The Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint

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