Depression Revealing Primary Sjögren’s Syndrome with Neurological Involvement

Abstract

15% of cases) but often serious and condition the prognosis [1,4].The most frequent of these disorders including pulmonary, renal, neurological, and digestive [1,4]. These systemic manifestations are very polymorphic, heterogeneous, and non-specific, justifying the qualification of this syndrome as a "great masquerader" [5]. The specific neurological involvement of this disease (neuro-Sjögren) is not uncommon but very polymorphic and often under-diagnosed [3,6]. Depression, classified among the manifestations of central neuro-Sjögren (involvement of the central nervous system) [6,7] can be seen in 32 to 46% of cases [8]. The inaugural forms of the disease are exceptional and represent a real diagnostic challenge for clinicians [5]. We report an original observation of depression as an initial and isolated manifestation revealing neuro-Sjögren.

Sjögren's syndrome with bipolar disorder, case report

“…The difference between this case and Salem Bouomrani et al [ 8 ] case is our patient's younger age and difference in clinical manifestations. As Bouomrani's patient presented depressive symptoms and did not respond to antidepressants while improving on Methylprednisolone pulse treatment followed by 1 mg/kg oral prednisolone.…”

“…Depression, anxiety, psychiatric features, and cognitive impairment are usually the most frequent [ 5 , 6 ]. However, the association with bipolar disorder seems rare and not frequently documented [ 7 , 8 ].…”