Familial Mediterranean fever (FMF) is the most common and best known of hereditary recurrent fever or periodic fever syndromes. It was described in 1945 and genetically characterized in 1992. It is caused by a point mutation in the MEFV gene located on the short arm of chromosome 16. It is particularly frequent among Sephardic Jews, Armenians, Turks and Middle Eastern Arabs, where the prevalence can reach 1/2000 to 1/1000. Recent publications described its frequent association with other diseases and/or syndromes, particularly those of autoimmune, genetic, and autoinflammatory origin. The objective of this review is to familiarize healthcare professionals with the main associations to look for in patients followed for FMF. The early detection of these associations makes it possible to improve the management and the prognosis of patients with FMF.

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15% of cases) but often serious and condition the prognosis [1,4].The most frequent of these disorders including pulmonary, renal, neurological, and digestive [1,4]. These systemic manifestations are very polymorphic, heterogeneous, and non-specific, justifying the qualification of this syndrome as a "great masquerader" [5]. The specific neurological involvement of this disease (neuro-Sjögren) is not uncommon but very polymorphic and often under-diagnosed [3,6]. Depression, classified among the manifestations of central neuro-Sjögren (involvement of the central nervous system) [6,7] can be seen in 32 to 46% of cases [8]. The inaugural forms of the disease are exceptional and represent a real diagnostic challenge for clinicians [5]. We report an original observation of depression as an initial and isolated manifestation revealing neuro-Sjögren.

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S.A.M.S. is an acronym for Seun Ayoade's Medical System [1], an alternative form of therapy based on the Germ Terrain Duality theory of disease. The Germ-Terrain duality theory of disease states that the etiology of certain diseases/diseased states is