Depression screening in pediatric epilepsy: Evidence for the benefit of a behavioral medicine service in early detection

Depressive Symptoms in Youth With Type 1 or Type 2 Diabetes: Results of the Pediatric Diabetes Consortium Screening Assessment of Depression in Diabetes Study

“…The first three categories were combined into a "symptoms" category with the last category considered "no symptoms" (9). BMI percentile was calculated using the 2000 Centers for Disease Control and Prevention population growth chart data (10).…”

Symptoms of anxiety and depression in school-aged children with active epilepsy: A population-based study

“…There is accumulating evidence that symptoms of both depression [34,35] and anxiety [36] can be successfully treated in children with epilepsy although larger-scale studies are needed. A pilot study suggests that cognitive behavioral therapy (CBT) may be useful in treating children with epilepsy and social anxiety [37], and there is a need for more studies focusing on specific types of depression and anxiety in childhood epilepsy.…”

Prediction of specific depressive symptom clusters in youth with epilepsy: The NDDI‐E‐Y versus Neuro‐QOL SF

“…1 Depression or clinical depressive symptoms are present in 10-30% of YWE. 1,2,4 Because of the overlap between antiepileptic drug (AED) side effects, seizure semiology, and depressive symptoms in youth (e.g., irritability, loss of energy, mood changes, and difficulties with attention and concentration), a differential diagnosis of depression in YWE can be challenging. 1,2,4 Because of the overlap between antiepileptic drug (AED) side effects, seizure semiology, and depressive symptoms in youth (e.g., irritability, loss of energy, mood changes, and difficulties with attention and concentration), a differential diagnosis of depression in YWE can be challenging.…”

“…5 Furthermore, the U.S. Food and Drug Administration (FDA) has issued an alert for risk of increased SI with AED use in YWE, 6 complicating the clinical assessment of depressive symptoms in YWE. 2,3,14 Experts have agreed that the relationship between epilepsy, SI, sociodemographic variables, and AED use is complex and multifactorial. 7 Findings on the relationship between seizure variables (e.g., frequency, severity, and type) and sociodemographic (e.g., age, and gender) and depressive symptoms have been unequivocal, with some studies showing a relationship and others finding no association.…”

“…The 11-item Neurological Disorders Depression Inventory-Epilepsy for Youth (NDDI-E-Y) was adapted from the adult version of the NDDI-E, which excluded symptoms related to AED side effects. 29 The current gold standard self-report evaluation of pediatric depressive symptoms is the Children's Depression Inventory-2 (CDI-2), which has been used in both epilepsy clinical and research settings, 2,12 and is listed as a common data element for depression in pediatric epilepsy (https://commondataelements.ninds.nih.gov/Epilepsy.aspx# tab=Data_Standards). 10,12 In addition, the Pediatric Neuro-QOL was designed to assess health-related quality of life (HRQoL) in children with neurologic conditions, including epilepsy, and contains an 8-item Depression Short Form (Neuro-QOL SF).…”