Depression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis

Sin, Nancy L.; DiMatteo, M. Robin

doi:10.1007/s12160-013-9559-6

Cited by 230 publications

(174 citation statements)

References 61 publications

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“…Depression is known to have adverse effects on HIV-related outcomes, for example there is a substantial evidence base that depression reduces adherence to anti-retroviral medication (ART) (Sin & DiMatteo, 2014). Potentially related to reduced adherence, a study which followed up women 6-8 years after birth reported that women with depression were significantly more likely to have an increased rate of disease progression (hazard ratio, HR ¼1.61; 95% CI ¼ 1.28-2.03) and 2-fold increased risk of death (HR ¼2.65; 95% CI ¼ 1.89-3.71) (Bing et al, 2001).…”

Section: Ipv Hiv and Mental Health Burden In Africamentioning

confidence: 99%

Intimate partner violence, HIV, and mental health: a triple epidemic of global proportions

Mitchell

Wight

Heerden

et al. 2016

International Review of Psychiatry

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Intimate partner violence (IPV) is a global health problem of epidemic proportions, affecting a third of women across the globe and as many as 60% in heavily affected regions of Africa. There is strong evidence that risk of IPV is heightened in HIV-infected women, and emerging evidence linking experiencing IPV and/or HIV to a higher likelihood of experiencing mental health problems. This triple burden makes women in Africa, living in the epicentre of HIV, all the more vulnerable. In this synthesis, this study reviewed literature pertaining to the overlap of IPV, HIV, and mental health problems. It presents a series of geographical maps illustrating the heavy burden of IPV and HIV globally, and how these coincide with a growing prevalence of mental health problems in Africa. Furthermore, it presents evidence on: the association between IPV and HIV, shared risk factors, and health consequences. This synthesis sheds light on the fact that $30% of women are affected by these three burdens concurrently, and the need for intervention is essential. Promising large scale interventions which have taken place in Africa are described, and evidence is presented in support of integrated versus targeted screening. ARTICLE HISTORY

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Section: Ipv Hiv and Mental Health Burden In Africamentioning

confidence: 99%

Intimate partner violence, HIV, and mental health: a triple epidemic of global proportions

Mitchell

Wight

Heerden

et al. 2016

International Review of Psychiatry

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“…21 Given the above, it is critical from a public and individual perspective to investigate and describe the interventions that are effective in improving adherence to ART. Systematic reviews report that there is limited evidence on interventions to improve adherence to ART in the pediatric population; 22 yet older adults are less likely to be non-adherent; 23 there may be benefit in addressing mental health issues that affect adherence; 5,24,25 motivational interviewing may offer some benefit, 26 and reduce viral load in youth. 27 Weekly reminder text messages [28][29][30] and treatment supporters 29 also improve adherence and reduce viral load in low resource settings.…”

Section: Introductionmentioning

confidence: 99%

Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies

Mbuagbaw

Sivaramalingam

Navarro

et al. 2015

AIDS Patient Care and STDs

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We sought to review the effectiveness of interventions designed to improve adherence to antiretroviral therapy (ART) from studies included in a recent Cochrane review that reported a clinical and an adherence outcome, with at least 80% follow-up for 6 months or more. Data were extracted independently and in duplicate, with an adjudicator for disagreements. Risk of bias was assessed using the Cochrane Risk of Bias tool. Of 182 relevant studies in the Cochrane review, 49 were related to ART. Statistical pooling was not warranted due to heterogeneity in interventions, participants, treatments, adherence measures and outcomes. Many studies had high risk of bias in elements of design and outcome ascertainment. Only 10 studies improved both adherence and clinical outcomes. These used the following interventions: adherence counselling (two studies); a once-daily regimen (compared to twice daily); text messaging; web-based cognitive behavioral intervention; face-to-face multi-session intensive behavioral interventions (two studies); contingency management; modified directly observed therapy; and nurse-delivered home visits combined with telephone calls. Patient-related adherence interventions were the most frequently tested. Uniform adherence measures and higher quality studies of younger populations are encouraged.

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“…(10) Some authors present a high prevalence of depression in PLHA, exerting a significant impact in the development of diseases and being registered as one of the main causes of suicide and psychiatric appointments. (6) Despite the high depression rates identified in this population, however, knowledge gaps about depression remain among PLHA in low and middle-income countries. (4) And the difference in the depressive symptoms of men and women living with HIV in Brazil according to the BDI domains is not understood yet, which made it difficult to compare these results with other studies developed in the country.…”

Section: Discussionmentioning

confidence: 98%

“…(4) In PLHA, it is known for being negatively associated with worse compliance with antiretroviral treatment, (5) therapeutic outcomes and risk behaviors, (6) besides its considerable impact in the treatment and social relationships (7) and in the more rapid progression to Aids and death. (1) Hence, the importance of measuring and understanding the influence of depression in this population is highlighted.…”

Section: Introductionmentioning

confidence: 99%

Avaliação dos sintomas depressivos somáticos e afetivo-cognitivos de pessoas vivendo com HIV/AIDS

et al. 2017

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Objective: To analyze the somatic and affective-cognitive symptoms of depression according to the sex of people living with HIV/AIDS. Methods: Analytic study developed at specialized care services in Ribeirão Preto-SP, including a sample of 331 participants. To collect the data, a sociodemographic characterization tool and Beck's Depression Inventory (BDI) were used. Results: Among the interviewees, 50.4% were male, 52.1% of whom in the age range between 20 and 35 years. Higher education (p=0.001) and lower income (<0.001) were found for the women and more comorbidities (p=0.004) for the men. It was identified that the women presented higher mean depression scores in the somatic (p<0.001) as well as in the affective/cognitive domains (p<0.001). Conclusion: These study results appoint that the women present higher depressive symptom scores than the man, in the somatic as well as in the affective/cognitive domains of the BDI subscales. ResumoObjetivo: Analisar os sintomas somáticos e afetivo-cognitivos de depressão segundo o sexo de pessoas que vivem com HIV/AIDS. Métodos: Estudo analítico realizado em serviços de atendimento especializado em Ribeirão Preto-SP, com amostra de 331 participantes. Para coleta de dados foram utilizados instrumento de caracterização sociodemográfica e o Inventário de Depressão de Beck (BDI). Resultados: Dos entrevistados, 50,4% eram do sexo masculino e destes, 52,1% estavam na faixa etária de 20 a 35 anos. As mulheres apresentaram maior escolaridade (p=0,001) e menor renda (<0,001), e os homens apresentaram mais comorbidades (p=0,004). Identificou-se que as mulheres apresentaram maiores médias de escores de depressão, tanto no domínio somático (p<0,001) quanto no afetivo/cognitivo (p<0,001). Conclusão: Os resultados deste estudo apontam que as mulheres apresentam maiores escores de sintomatologia depressiva do que os homens, tanto no domínio somático quanto no afetivo/cognitivo das subescalas do IDB.

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Depression Treatment Enhances Adherence to Antiretroviral Therapy: a Meta-Analysis

Cited by 230 publications

References 61 publications

Intimate partner violence, HIV, and mental health: a triple epidemic of global proportions

Intimate partner violence, HIV, and mental health: a triple epidemic of global proportions

Interventions for Enhancing Adherence to Antiretroviral Therapy (ART): A Systematic Review of High Quality Studies

Avaliação dos sintomas depressivos somáticos e afetivo-cognitivos de pessoas vivendo com HIV/AIDS

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